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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: LGI1_HUMAN (O95970)

Summary

This is the summary of UniProt entry LGI1_HUMAN (O95970).

Description: Leucine-rich glioma-inactivated protein 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 557 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 34
low_complexity n/a 23 31
low_complexity n/a 35 44
Pfam LRR_8 69 127
Pfam LRR_8 115 175
Pfam EPTP 225 266
Pfam EPTP 271 312
Pfam EPTP 317 363
Pfam EPTP 419 461
Pfam EPTP 464 505
Pfam EPTP 510 551

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O95970. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MESERSKRMG NACIPLKRIA YFLCLLSALL LTEGKKPAKP KCPAVCTCTK
50
51
DNALCENARS IPRTVPPDVI SLSFVRSGFT EISEGSFLFT PSLQLLLFTS
100
101
NSFDVISDDA FIGLPHLEYL FIENNNIKSI SRHTFRGLKS LIHLSLANNN
150
151
LQTLPKDIFK GLDSLTNVDL RGNSFNCDCK LKWLVEWLGH TNATVEDIYC
200
201
EGPPEYKKRK INSLSSKDFD CIITEFAKSQ DLPYQSLSID TFSYLNDEYV
250
251
VIAQPFTGKC IFLEWDHVEK TFRNYDNITG TSTVVCKPIV IETQLYVIVA
300
301
QLFGGSHIYK RDSFANKFIK IQDIEILKIR KPNDIETFKI ENNWYFVVAD
350
351
SSKAGFTTIY KWNGNGFYSH QSLHAWYRDT DVEYLEIVRT PQTLRTPHLI
400
401
LSSSSQRPVI YQWNKATQLF TNQTDIPNME DVYAVKHFSV KGDVYICLTR
450
451
FIGDSKVMKW GGSSFQDIQR MPSRGSMVFQ PLQINNYQYA ILGSDYSFTQ
500
501
VYNWDAEKAK FVKFQELNVQ APRSFTHVSI NKRNFLFASS FKGNTQIYKH
550
551
VIVDLSA                                               
557
 

Show the unformatted sequence.

Checksums:
CRC64:890EEDA08D95C854
MD5:fadf9052dd72a2cb6b33506fd049d6e0

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
EPTP 225 - 266 5Y2Z B 225 - 266 Show 3D Structure View in InterPro
D 225 - 266 Show 3D Structure View in InterPro
F 225 - 266 Show 3D Structure View in InterPro
H 225 - 266 Show 3D Structure View in InterPro
J 225 - 266 Show 3D Structure View in InterPro
L 225 - 266 Show 3D Structure View in InterPro
5Y31 B 225 - 266 Show 3D Structure View in InterPro
D 225 - 266 Show 3D Structure View in InterPro
271 - 312 5Y2Z B 271 - 312 Show 3D Structure View in InterPro
D 271 - 312 Show 3D Structure View in InterPro
F 271 - 312 Show 3D Structure View in InterPro
H 271 - 312 Show 3D Structure View in InterPro
J 271 - 312 Show 3D Structure View in InterPro
L 271 - 312 Show 3D Structure View in InterPro
5Y31 B 271 - 312 Show 3D Structure View in InterPro
D 271 - 312 Show 3D Structure View in InterPro
317 - 363 5Y2Z B 317 - 363 Show 3D Structure View in InterPro
D 317 - 363 Show 3D Structure View in InterPro
F 317 - 363 Show 3D Structure View in InterPro
H 317 - 363 Show 3D Structure View in InterPro
J 317 - 363 Show 3D Structure View in InterPro
L 317 - 363 Show 3D Structure View in InterPro
5Y31 B 317 - 363 Show 3D Structure View in InterPro
D 317 - 363 Show 3D Structure View in InterPro
419 - 461 5Y2Z B 419 - 461 Show 3D Structure View in InterPro
D 419 - 461 Show 3D Structure View in InterPro
F 419 - 461 Show 3D Structure View in InterPro
H 419 - 461 Show 3D Structure View in InterPro
J 419 - 461 Show 3D Structure View in InterPro
L 419 - 461 Show 3D Structure View in InterPro
5Y31 B 419 - 461 Show 3D Structure View in InterPro
D 419 - 461 Show 3D Structure View in InterPro
464 - 505 5Y2Z B 464 - 505 Show 3D Structure View in InterPro
D 464 - 505 Show 3D Structure View in InterPro
F 464 - 505 Show 3D Structure View in InterPro
H 464 - 505 Show 3D Structure View in InterPro
J 464 - 505 Show 3D Structure View in InterPro
L 464 - 505 Show 3D Structure View in InterPro
5Y31 B 464 - 505 Show 3D Structure View in InterPro
D 464 - 505 Show 3D Structure View in InterPro
510 - 551 5Y2Z B 510 - 551 Show 3D Structure View in InterPro
D 510 - 551 Show 3D Structure View in InterPro
F 510 - 551 Show 3D Structure View in InterPro
H 510 - 551 Show 3D Structure View in InterPro
J 510 - 551 Show 3D Structure View in InterPro
L 510 - 551 Show 3D Structure View in InterPro
5Y31 B 510 - 551 Show 3D Structure View in InterPro
D 510 - 551 Show 3D Structure View in InterPro
LRR_8 115 - 175 5Y30 A 115 - 175 Show 3D Structure View in InterPro
5Y31 B 115 - 175 Show 3D Structure View in InterPro
D 115 - 175 Show 3D Structure View in InterPro
69 - 127 5Y30 A 69 - 127 Show 3D Structure View in InterPro
5Y31 B 69 - 127 Show 3D Structure View in InterPro
D 69 - 127 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;