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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CERU_HUMAN (P00450)

Summary

This is the summary of UniProt entry CERU_HUMAN (P00450).

Description: Ceruloplasmin EC=1.16.3.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 1065 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 19
Pfam Cu-oxidase_3 74 204
disorder n/a 161 162
Pfam Cu-oxidase 221 358
disorder n/a 247 248
disorder n/a 250 253
disorder n/a 434 437
disorder n/a 439 441
disorder n/a 489 498
disorder n/a 500 507
disorder n/a 520 521
disorder n/a 604 615
Pfam Cu-oxidase_3 802 903
Pfam Cu-oxidase_2 937 1060
disorder n/a 1061 1062

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P00450. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MKILILGIFL FLCSTPAWAK EKHYYIGIIE TTWDYASDHG EKKLISVDTE
50
51
HSNIYLQNGP DRIGRLYKKA LYLQYTDETF RTTIEKPVWL GFLGPIIKAE
100
101
TGDKVYVHLK NLASRPYTFH SHGITYYKEH EGAIYPDNTT DFQRADDKVY
150
151
PGEQYTYMLL ATEEQSPGEG DGNCVTRIYH SHIDAPKDIA SGLIGPLIIC
200
201
KKDSLDKEKE KHIDREFVVM FSVVDENFSW YLEDNIKTYC SEPEKVDKDN
250
251
EDFQESNRMY SVNGYTFGSL PGLSMCAEDR VKWYLFGMGN EVDVHAAFFH
300
301
GQALTNKNYR IDTINLFPAT LFDAYMVAQN PGEWMLSCQN LNHLKAGLQA
350
351
FFQVQECNKS SSKDNIRGKH VRHYYIAAEE IIWNYAPSGI DIFTKENLTA
400
401
PGSDSAVFFE QGTTRIGGSY KKLVYREYTD ASFTNRKERG PEEEHLGILG
450
451
PVIWAEVGDT IRVTFHNKGA YPLSIEPIGV RFNKNNEGTY YSPNYNPQSR
500
501
SVPPSASHVA PTETFTYEWT VPKEVGPTNA DPVCLAKMYY SAVDPTKDIF
550
551
TGLIGPMKIC KKGSLHANGR QKDVDKEFYL FPTVFDENES LLLEDNIRMF
600
601
TTAPDQVDKE DEDFQESNKM HSMNGFMYGN QPGLTMCKGD SVVWYLFSAG
650
651
NEADVHGIYF SGNTYLWRGE RRDTANLFPQ TSLTLHMWPD TEGTFNVECL
700
701
TTDHYTGGMK QKYTVNQCRR QSEDSTFYLG ERTYYIAAVE VEWDYSPQRE
750
751
WEKELHHLQE QNVSNAFLDK GEFYIGSKYK KVVYRQYTDS TFRVPVERKA
800
801
EEEHLGILGP QLHADVGDKV KIIFKNMATR PYSIHAHGVQ TESSTVTPTL
850
851
PGETLTYVWK IPERSGAGTE DSACIPWAYY STVDQVKDLY SGLIGPLIVC
900
901
RRPYLKVFNP RRKLEFALLF LVFDENESWY LDDNIKTYSD HPEKVNKDDE
950
951
EFIESNKMHA INGRMFGNLQ GLTMHVGDEV NWYLMGMGNE IDLHTVHFHG
1000
1001
HSFQYKHRGV YSSDVFDIFP GTYQTLEMFP RTPGIWLLHC HVTDHIHAGM
1050
1051
ETTYTVLQNE DTKSG                                      
1065
 

Show the unformatted sequence.

Checksums:
CRC64:2F2F1294E2D30F58
MD5:de32069d28f47f988a531a4b12a2fdf2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Cu-oxidase 221 - 357 1KCW A 202 - 338 Jmol OpenAstexViewer
221 - 358 2J5W A 202 - 339 Jmol OpenAstexViewer
4EJX A 202 - 339 Jmol OpenAstexViewer
4ENZ A 202 - 339 Jmol OpenAstexViewer
Cu-oxidase_2 937 - 1059 1KCW A 918 - 1040 Jmol OpenAstexViewer
4ENZ A 918 - 1040 Jmol OpenAstexViewer
937 - 1060 2J5W A 918 - 1041 Jmol OpenAstexViewer
4EJX A 918 - 1041 Jmol OpenAstexViewer
Cu-oxidase_3 74 - 204 1KCW A 55 - 185 Jmol OpenAstexViewer
2J5W A 55 - 185 Jmol OpenAstexViewer
4EJX A 55 - 185 Jmol OpenAstexViewer
4ENZ A 55 - 185 Jmol OpenAstexViewer
802 - 903 1KCW A 783 - 884 Jmol OpenAstexViewer
2J5W A 783 - 884 Jmol OpenAstexViewer
4EJX A 783 - 884 Jmol OpenAstexViewer
4ENZ A 783 - 884 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.