Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
36  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PNPH_HUMAN (P00491)

Summary

This is the summary of UniProt entry PNPH_HUMAN (P00491).

Description: Purine nucleoside phosphorylase EC=2.4.2.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 289 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
Pfam PNP_UDP_1 26 280
disorder n/a 152 154

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P00491. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MENGYTYEDY KNTAEWLLSH TKHRPQVAII CGSGLGGLTD KLTQAQIFDY
50
51
GEIPNFPRST VPGHAGRLVF GFLNGRACVM MQGRFHMYEG YPLWKVTFPV
100
101
RVFHLLGVDT LVVTNAAGGL NPKFEVGDIM LIRDHINLPG FSGQNPLRGP
150
151
NDERFGDRFP AMSDAYDRTM RQRALSTWKQ MGEQRELQEG TYVMVAGPSF
200
201
ETVAECRVLQ KLGADAVGMS TVPEVIVARH CGLRVFGFSL ITNKVIMDYE
250
251
SLEKANHEEV LAAGKQAAQK LEQFVSILMA SIPLPDKAS            
289
 

Show the unformatted sequence.

Checksums:
CRC64:91622FB1D26479D3
MD5:79456757831a6233f4155e8a4a37bb48

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
PNP_UDP_1 26 - 280 1M73 E 26 - 280 Jmol OpenAstexViewer
1PF7 E 26 - 280 Jmol OpenAstexViewer
1PWY E 26 - 280 Jmol OpenAstexViewer
1RCT E 26 - 280 Jmol OpenAstexViewer
1RFG E 26 - 280 Jmol OpenAstexViewer
1RR6 A 26 - 280 Jmol OpenAstexViewer
1RSZ A 26 - 280 Jmol OpenAstexViewer
1RT9 A 26 - 280 Jmol OpenAstexViewer
1ULA A 26 - 280 Jmol OpenAstexViewer
1ULB A 26 - 280 Jmol OpenAstexViewer
1V2H E 26 - 280 Jmol OpenAstexViewer
1V3Q E 26 - 280 Jmol OpenAstexViewer
1V41 E 26 - 280 Jmol OpenAstexViewer
1V45 E 26 - 280 Jmol OpenAstexViewer
1YRY E 26 - 280 Jmol OpenAstexViewer
2A0W A 26 - 280 Jmol OpenAstexViewer
2A0X A 26 - 280 Jmol OpenAstexViewer
2A0Y A 26 - 280 Jmol OpenAstexViewer
2OC4 A 26 - 280 Jmol OpenAstexViewer
2OC9 A 26 - 280 Jmol OpenAstexViewer
2ON6 A 26 - 280 Jmol OpenAstexViewer
2Q7O E 26 - 280 Jmol OpenAstexViewer
3BGS A 26 - 280 Jmol OpenAstexViewer
3D1V A 26 - 280 Jmol OpenAstexViewer
3GB9 A 26 - 280 Jmol OpenAstexViewer
B 26 - 280 Jmol OpenAstexViewer
C 26 - 280 Jmol OpenAstexViewer
3GGS A 26 - 280 Jmol OpenAstexViewer
B 26 - 280 Jmol OpenAstexViewer
C 26 - 280 Jmol OpenAstexViewer
3INY A 26 - 280 Jmol OpenAstexViewer
3K8O E 26 - 280 Jmol OpenAstexViewer
Q 26 - 280 Jmol OpenAstexViewer
S 26 - 280 Jmol OpenAstexViewer
T 26 - 280 Jmol OpenAstexViewer
U 26 - 280 Jmol OpenAstexViewer
Y 26 - 280 Jmol OpenAstexViewer
3K8Q A 26 - 280 Jmol OpenAstexViewer
3PHB E 26 - 280 Jmol OpenAstexViewer
Q 26 - 280 Jmol OpenAstexViewer
S 26 - 280 Jmol OpenAstexViewer
T 26 - 280 Jmol OpenAstexViewer
U 26 - 280 Jmol OpenAstexViewer
Y 26 - 280 Jmol OpenAstexViewer
4EAR A 26 - 280 Jmol OpenAstexViewer
B 26 - 280 Jmol OpenAstexViewer
C 26 - 280 Jmol OpenAstexViewer
4EB8 A 26 - 280 Jmol OpenAstexViewer
B 26 - 280 Jmol OpenAstexViewer
C 26 - 280 Jmol OpenAstexViewer
4ECE A 26 - 280 Jmol OpenAstexViewer
B 26 - 280 Jmol OpenAstexViewer
C 26 - 280 Jmol OpenAstexViewer
D 26 - 280 Jmol OpenAstexViewer
E 26 - 280 Jmol OpenAstexViewer
F 26 - 280 Jmol OpenAstexViewer
4GKA A 26 - 280 Jmol OpenAstexViewer
B 26 - 280 Jmol OpenAstexViewer
C 26 - 280 Jmol OpenAstexViewer
D 26 - 280 Jmol OpenAstexViewer
E 26 - 280 Jmol OpenAstexViewer
F 26 - 280 Jmol OpenAstexViewer
5ETJ A 26 - 280 Jmol OpenAstexViewer
B 26 - 280 Jmol OpenAstexViewer
C 26 - 280 Jmol OpenAstexViewer
D 26 - 280 Jmol OpenAstexViewer
E 26 - 280 Jmol OpenAstexViewer
F 26 - 280 Jmol OpenAstexViewer
5UGF A 26 - 280 Jmol OpenAstexViewer
B 26 - 280 Jmol OpenAstexViewer
C 26 - 280 Jmol OpenAstexViewer
D 26 - 280 Jmol OpenAstexViewer
E 26 - 280 Jmol OpenAstexViewer
F 26 - 280 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.