Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
65  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ABL1_HUMAN (P00519)

Summary

This is the summary of UniProt entry ABL1_HUMAN (P00519).

Description: Tyrosine-protein kinase ABL1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1130 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
low_complexity n/a 4 22
disorder n/a 53 54
Pfam SH3_1 67 113
Pfam SH2 127 202
Pfam PK_Tyr_Ser-Thr 242 493
low_complexity n/a 248 259
disorder n/a 489 490
disorder n/a 503 511
disorder n/a 513 719
low_complexity n/a 604 615
low_complexity n/a 628 638
low_complexity n/a 700 709
disorder n/a 724 993
low_complexity n/a 895 914
low_complexity n/a 976 992
disorder n/a 1009 1010
disorder n/a 1013 1021
disorder n/a 1023 1027
Pfam F_actin_bind 1025 1130

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P00519. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MLEICLKLVG CKSKKGLSSS SSCYLEEALQ RPVASDFEPQ GLSEAARWNS
50
51
KENLLAGPSE NDPNLFVALY DFVASGDNTL SITKGEKLRV LGYNHNGEWC
100
101
EAQTKNGQGW VPSNYITPVN SLEKHSWYHG PVSRNAAEYL LSSGINGSFL
150
151
VRESESSPGQ RSISLRYEGR VYHYRINTAS DGKLYVSSES RFNTLAELVH
200
201
HHSTVADGLI TTLHYPAPKR NKPTVYGVSP NYDKWEMERT DITMKHKLGG
250
251
GQYGEVYEGV WKKYSLTVAV KTLKEDTMEV EEFLKEAAVM KEIKHPNLVQ
300
301
LLGVCTREPP FYIITEFMTY GNLLDYLREC NRQEVNAVVL LYMATQISSA
350
351
MEYLEKKNFI HRDLAARNCL VGENHLVKVA DFGLSRLMTG DTYTAHAGAK
400
401
FPIKWTAPES LAYNKFSIKS DVWAFGVLLW EIATYGMSPY PGIDLSQVYE
450
451
LLEKDYRMER PEGCPEKVYE LMRACWQWNP SDRPSFAEIH QAFETMFQES
500
501
SISDEVEKEL GKQGVRGAVS TLLQAPELPT KTRTSRRAAE HRDTTDVPEM
550
551
PHSKGQGESD PLDHEPAVSP LLPRKERGPP EGGLNEDERL LPKDKKTNLF
600
601
SALIKKKKKT APTPPKRSSS FREMDGQPER RGAGEEEGRD ISNGALAFTP
650
651
LDTADPAKSP KPSNGAGVPN GALRESGGSG FRSPHLWKKS STLTSSRLAT
700
701
GEEEGGGSSS KRFLRSCSAS CVPHGAKDTE WRSVTLPRDL QSTGRQFDSS
750
751
TFGGHKSEKP ALPRKRAGEN RSDQVTRGTV TPPPRLVKKN EEAADEVFKD
800
801
IMESSPGSSP PNLTPKPLRR QVTVAPASGL PHKEEAGKGS ALGTPAAAEP
850
851
VTPTSKAGSG APGGTSKGPA EESRVRRHKH SSESPGRDKG KLSRLKPAPP
900
901
PPPAASAGKA GGKPSQSPSQ EAAGEAVLGA KTKATSLVDA VNSDAAKPSQ
950
951
PGEGLKKPVL PATPKPQSAK PSGTPISPAP VPSTLPSASS ALAGDQPSST
1000
1001
AFIPLISTRV SLRKTRQPPE RIASGAITKG VVLDSTEALC LAISRNSEQM
1050
1051
ASHSAVLEAG KNLYTFCVSY VDSIQQMRNK FAFREAINKL ENNLRELQIC
1100
1101
PATAGSGPAA TQDFSKLLSS VKEISDIVQR                      
1130
 

Show the unformatted sequence.

Checksums:
CRC64:85FE6C1C0E483EA2
MD5:d24f1ea01ac4c8d96e75dd9550a0fb09

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
F_actin_bind 1025 - 1130 1ZZP A 32 - 137 Jmol OpenAstexViewer
PK_Tyr_Ser-Thr 242 - 493 1OPL A 261 - 512 Jmol OpenAstexViewer
B 261 - 512 Jmol OpenAstexViewer
2E2B A 242 - 493 Jmol OpenAstexViewer
B 242 - 493 Jmol OpenAstexViewer
2F4J A 242 - 493 Jmol OpenAstexViewer
2FO0 A 261 - 512 Jmol OpenAstexViewer
2G1T A 242 - 493 Jmol OpenAstexViewer
B 242 - 493 Jmol OpenAstexViewer
C 242 - 493 Jmol OpenAstexViewer
D 242 - 493 Jmol OpenAstexViewer
2G2F A 242 - 493 Jmol OpenAstexViewer
B 242 - 493 Jmol OpenAstexViewer
2G2H A 261 - 512 Jmol OpenAstexViewer
B 261 - 512 Jmol OpenAstexViewer
2G2I A 242 - 493 Jmol OpenAstexViewer
B 242 - 493 Jmol OpenAstexViewer
2GQG A 242 - 493 Jmol OpenAstexViewer
B 242 - 493 Jmol OpenAstexViewer
2HIW A 260 - 511 Jmol OpenAstexViewer
B 260 - 511 Jmol OpenAstexViewer
2HYY A 242 - 493 Jmol OpenAstexViewer
B 242 - 493 Jmol OpenAstexViewer
C 242 - 493 Jmol OpenAstexViewer
D 242 - 493 Jmol OpenAstexViewer
2HZ0 A 242 - 493 Jmol OpenAstexViewer
B 242 - 493 Jmol OpenAstexViewer
2HZ4 A 242 - 493 Jmol OpenAstexViewer
B 242 - 493 Jmol OpenAstexViewer
C 242 - 493 Jmol OpenAstexViewer
2HZI A 242 - 493 Jmol OpenAstexViewer
B 242 - 493 Jmol OpenAstexViewer
2V7A A 242 - 493 Jmol OpenAstexViewer
B 242 - 493 Jmol OpenAstexViewer
3CS9 A 242 - 493 Jmol OpenAstexViewer
B 242 - 493 Jmol OpenAstexViewer
C 242 - 493 Jmol OpenAstexViewer
D 242 - 493 Jmol OpenAstexViewer
3PYY A 261 - 512 Jmol OpenAstexViewer
B 261 - 512 Jmol OpenAstexViewer
3QRI A 242 - 493 Jmol OpenAstexViewer
B 242 - 493 Jmol OpenAstexViewer
3QRJ A 242 - 493 Jmol OpenAstexViewer
B 242 - 493 Jmol OpenAstexViewer
3QRK A 242 - 493 Jmol OpenAstexViewer
3UE4 A 242 - 493 Jmol OpenAstexViewer
B 242 - 493 Jmol OpenAstexViewer
4TWP A 242 - 493 Jmol OpenAstexViewer
B 242 - 493 Jmol OpenAstexViewer
4XEY A 261 - 512 Jmol OpenAstexViewer
B 261 - 512 Jmol OpenAstexViewer
4YC8 A 242 - 493 Jmol OpenAstexViewer
B 242 - 493 Jmol OpenAstexViewer
4ZOG A 242 - 493 Jmol OpenAstexViewer
B 242 - 493 Jmol OpenAstexViewer
5HU9 A 242 - 493 Jmol OpenAstexViewer
5MO4 A 261 - 512 Jmol OpenAstexViewer
6BL8 A 242 - 493 Jmol OpenAstexViewer
B 242 - 493 Jmol OpenAstexViewer
6NPE A 261 - 512 Jmol OpenAstexViewer
B 261 - 512 Jmol OpenAstexViewer
6NPU A 261 - 512 Jmol OpenAstexViewer
B 261 - 512 Jmol OpenAstexViewer
6NPV A 261 - 512 Jmol OpenAstexViewer
B 261 - 512 Jmol OpenAstexViewer
246 - 493 4WA9 A 246 - 493 Jmol OpenAstexViewer
B 246 - 493 Jmol OpenAstexViewer
SH2 127 - 202 1AB2 A 11 - 86 Jmol OpenAstexViewer
1OPL A 146 - 221 Jmol OpenAstexViewer
B 146 - 221 Jmol OpenAstexViewer
2ABL A 146 - 221 Jmol OpenAstexViewer
2FO0 A 146 - 221 Jmol OpenAstexViewer
3K2M A 146 - 221 Jmol OpenAstexViewer
B 146 - 221 Jmol OpenAstexViewer
3T04 A 146 - 221 Jmol OpenAstexViewer
3UYO A 146 - 221 Jmol OpenAstexViewer
4XEY B 146 - 221 Jmol OpenAstexViewer
5DC0 B 146 - 221 Jmol OpenAstexViewer
5DC4 A 146 - 221 Jmol OpenAstexViewer
5DC9 A 146 - 221 Jmol OpenAstexViewer
5MO4 A 146 - 221 Jmol OpenAstexViewer
6AMV A 146 - 221 Jmol OpenAstexViewer
6AMW A 146 - 221 Jmol OpenAstexViewer
SH3_1 67 - 113 1AWO A 67 - 113 Jmol OpenAstexViewer
1BBZ A 4 - 50 Jmol OpenAstexViewer
C 4 - 50 Jmol OpenAstexViewer
E 4 - 50 Jmol OpenAstexViewer
G 4 - 50 Jmol OpenAstexViewer
1JU5 C 67 - 113 Jmol OpenAstexViewer
1OPL A 86 - 132 Jmol OpenAstexViewer
2ABL A 86 - 132 Jmol OpenAstexViewer
2FO0 A 86 - 132 Jmol OpenAstexViewer
2O88 A 67 - 113 Jmol OpenAstexViewer
B 67 - 113 Jmol OpenAstexViewer
3EG0 A 67 - 113 Jmol OpenAstexViewer
3EG1 A 67 - 113 Jmol OpenAstexViewer
B 67 - 113 Jmol OpenAstexViewer
3EG2 A 67 - 113 Jmol OpenAstexViewer
3EG3 A 67 - 113 Jmol OpenAstexViewer
3EGU A 67 - 113 Jmol OpenAstexViewer
4J9B A 67 - 113 Jmol OpenAstexViewer
4J9C A 67 - 113 Jmol OpenAstexViewer
4J9D A 67 - 113 Jmol OpenAstexViewer
C 67 - 113 Jmol OpenAstexViewer
E 67 - 113 Jmol OpenAstexViewer
4J9E A 67 - 113 Jmol OpenAstexViewer
C 67 - 113 Jmol OpenAstexViewer
E 67 - 113 Jmol OpenAstexViewer
4J9F A 67 - 113 Jmol OpenAstexViewer
C 67 - 113 Jmol OpenAstexViewer
E 67 - 113 Jmol OpenAstexViewer
4J9G A 67 - 113 Jmol OpenAstexViewer
C 67 - 113 Jmol OpenAstexViewer
E 67 - 113 Jmol OpenAstexViewer
4J9H A 67 - 113 Jmol OpenAstexViewer
B 67 - 113 Jmol OpenAstexViewer
C 67 - 113 Jmol OpenAstexViewer
D 67 - 113 Jmol OpenAstexViewer
E 67 - 113 Jmol OpenAstexViewer
F 67 - 113 Jmol OpenAstexViewer
4J9I A 67 - 113 Jmol OpenAstexViewer
C 67 - 113 Jmol OpenAstexViewer
E 67 - 113 Jmol OpenAstexViewer
4JJB A 67 - 113 Jmol OpenAstexViewer
4JJC A 67 - 113 Jmol OpenAstexViewer
4JJD A 67 - 113 Jmol OpenAstexViewer
5MO4 A 86 - 132 Jmol OpenAstexViewer
5NP2 A 67 - 113 Jmol OpenAstexViewer
B 67 - 113 Jmol OpenAstexViewer
5OAZ A 67 - 113 Jmol OpenAstexViewer
B 67 - 113 Jmol OpenAstexViewer
6AMV A 86 - 132 Jmol OpenAstexViewer
6AMW A 86 - 132 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.