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99  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SRC_CHICK (P00523)

Summary

This is the summary of UniProt entry SRC_CHICK (P00523).

Description: Proto-oncogene tyrosine-protein kinase Src EC=2.7.10.2
Source organism: Gallus gallus (Chicken) (NCBI taxonomy ID 9031)
View Pfam proteome data.
Length: 533 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 58
disorder n/a 62 77
Pfam SH3_1 87 134
disorder n/a 103 106
Pfam SH2 148 230
disorder n/a 160 161
Pfam Pkinase_Tyr 267 516
disorder n/a 530 533

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P00523. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGSSKSKPKD PSQRRRSLEP PDSTHHGGFP ASQTPNKTAA PDTHRTPSRS
50
51
FGTVATEPKL FGGFNTSDTV TSPQRAGALA GGVTTFVALY DYESRTETDL
100
101
SFKKGERLQI VNNTEGDWWL AHSLTTGQTG YIPSNYVAPS DSIQAEEWYF
150
151
GKITRRESER LLLNPENPRG TFLVRESETT KGAYCLSVSD FDNAKGLNVK
200
201
HYKIRKLDSG GFYITSRTQF SSLQQLVAYY SKHADGLCHR LTNVCPTSKP
250
251
QTQGLAKDAW EIPRESLRLE VKLGQGCFGE VWMGTWNGTT RVAIKTLKPG
300
301
TMSPEAFLQE AQVMKKLRHE KLVQLYAVVS EEPIYIVTEY MSKGSLLDFL
350
351
KGEMGKYLRL PQLVDMAAQI ASGMAYVERM NYVHRDLRAA NILVGENLVC
400
401
KVADFGLARL IEDNEYTARQ GAKFPIKWTA PEAALYGRFT IKSDVWSFGI
450
451
LLTELTTKGR VPYPGMVNRE VLDQVERGYR MPCPPECPES LHDLMCQCWR
500
501
KDPEERPTFE YLQAFLEDYF TSTEPQYQPG ENL                  
533
 

Show the unformatted sequence.

Checksums:
CRC64:ABDB036F7D63C30A
MD5:9a12224c6e3f0ee9fbcbff78ec282546

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Pkinase_Tyr 267 - 516 2HWO A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
2HWP A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
2OIQ A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
2PTK A 267 - 516 Jmol OpenAstexViewer
2QI8 A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
2QLQ A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
2QQ7 A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
3D7T B 267 - 516 Jmol OpenAstexViewer
3D7U B 267 - 516 Jmol OpenAstexViewer
D 267 - 516 Jmol OpenAstexViewer
3DQW A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
C 267 - 516 Jmol OpenAstexViewer
D 267 - 516 Jmol OpenAstexViewer
3DQX A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
3EL7 A 267 - 516 Jmol OpenAstexViewer
3EL8 A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
3EN4 A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
3EN5 A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
3EN6 A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
3EN7 A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
3F3T A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
3F3U A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
3F3V A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
3F3W A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
3F6X A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
C 267 - 516 Jmol OpenAstexViewer
D 267 - 516 Jmol OpenAstexViewer
3G5D A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
3G6G A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
3G6H A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
3GEQ A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
3LOK A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
3OEZ A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
3OF0 A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
3QLF A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
3QLG A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
3SVV A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
3TZ7 A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
3TZ8 A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
3TZ9 A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
3U4W A 267 - 516 Jmol OpenAstexViewer
3U51 A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
3UQF A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
3UQG A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
4AGW A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
4DGG A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
4FIC A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
4LGG A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
4LGH A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
4MCV A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
4O2P A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
4U5J A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
4YBJ A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
4YBK A 267 - 516 Jmol OpenAstexViewer
5BMM A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
5D10 A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
5D11 A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
5D12 A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
5J5S A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
5K9I A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
5SWH A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
5SYS A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
5T0P A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
5TEH A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
5XP5 A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
5XP7 A 267 - 516 Jmol OpenAstexViewer
B 267 - 516 Jmol OpenAstexViewer
SH2 148 - 230 1F1W A 148 - 230 Jmol OpenAstexViewer
1F2F A 148 - 230 Jmol OpenAstexViewer
1P13 A 161 - 243 Jmol OpenAstexViewer
B 161 - 243 Jmol OpenAstexViewer
2PTK A 148 - 230 Jmol OpenAstexViewer
SH3_1 87 - 134 1NLO C 11 - 58 Jmol OpenAstexViewer
1NLP C 11 - 58 Jmol OpenAstexViewer
1PRL C 11 - 58 Jmol OpenAstexViewer
1PRM C 11 - 58 Jmol OpenAstexViewer
1RLP C 11 - 58 Jmol OpenAstexViewer
1RLQ C 11 - 58 Jmol OpenAstexViewer
1SRL A 11 - 58 Jmol OpenAstexViewer
1SRM A 11 - 58 Jmol OpenAstexViewer
2PTK A 87 - 134 Jmol OpenAstexViewer
3FJ5 A 87 - 134 Jmol OpenAstexViewer
B 87 - 134 Jmol OpenAstexViewer
4HVU A 87 - 134 Jmol OpenAstexViewer
4HVV A 87 - 134 Jmol OpenAstexViewer
4HVW A 87 - 134 Jmol OpenAstexViewer
4JZ3 A 87 - 134 Jmol OpenAstexViewer
4JZ4 A 87 - 134 Jmol OpenAstexViewer
B 87 - 134 Jmol OpenAstexViewer
4LE9 A 87 - 134 Jmol OpenAstexViewer
4OML A 87 - 134 Jmol OpenAstexViewer
4OMM A 87 - 134 Jmol OpenAstexViewer
4OMN A 87 - 134 Jmol OpenAstexViewer
4OMO A 87 - 134 Jmol OpenAstexViewer
B 87 - 134 Jmol OpenAstexViewer
4OMP A 87 - 134 Jmol OpenAstexViewer
4OMQ A 87 - 134 Jmol OpenAstexViewer
4QT7 A 87 - 134 Jmol OpenAstexViewer
4RTU A 87 - 134 Jmol OpenAstexViewer
4RTV A 87 - 134 Jmol OpenAstexViewer
4RTW A 87 - 134 Jmol OpenAstexViewer
C 87 - 134 Jmol OpenAstexViewer
4RTX A 87 - 134 Jmol OpenAstexViewer
B 87 - 134 Jmol OpenAstexViewer
C 87 - 134 Jmol OpenAstexViewer
D 87 - 134 Jmol OpenAstexViewer
4RTY A 87 - 134 Jmol OpenAstexViewer
4RTZ A 87 - 134 Jmol OpenAstexViewer
5EC7 A 87 - 134 Jmol OpenAstexViewer
B 87 - 134 Jmol OpenAstexViewer
C 87 - 134 Jmol OpenAstexViewer
5ECA A 87 - 134 Jmol OpenAstexViewer
5I11 A 87 - 134 Jmol OpenAstexViewer
5OAV A 87 - 134 Jmol OpenAstexViewer
C 87 - 134 Jmol OpenAstexViewer
5OB0 A 87 - 134 Jmol OpenAstexViewer
5OB1 A 87 - 134 Jmol OpenAstexViewer
5OB2 A 87 - 134 Jmol OpenAstexViewer
C 87 - 134 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.