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14  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DPO1_ECOLI (P00582)

Summary

This is the summary of UniProt entry DPO1_ECOLI (P00582).

Description: DNA polymerase I EC=2.7.7.7
Source organism: Escherichia coli (strain K12) (NCBI taxonomy ID 83333)
Length: 928 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam 5_3_exonuc_N 8 170
disorder n/a 75 76
disorder n/a 85 86
disorder n/a 88 89
low_complexity n/a 146 159
Pfam 5_3_exonuc 171 273
disorder n/a 191 193
low_complexity n/a 201 211
low_complexity n/a 299 308
disorder n/a 307 314
Pfam DNA_pol_A_exo1 330 517
low_complexity n/a 402 416
Pfam DNA_pol_A 549 926
coiled_coil n/a 556 576
disorder n/a 600 611
disorder n/a 659 664
disorder n/a 666 667
disorder n/a 669 682
low_complexity n/a 834 843
disorder n/a 839 841
disorder n/a 926 928

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P00582. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MVQIPQNPLI LVDGSSYLYR AYHAFPPLTN SAGEPTGAMY GVLNMLRSLI
50
51
MQYKPTHAAV VFDAKGKTFR DELFEHYKSH RPPMPDDLRA QIEPLHAMVK
100
101
AMGLPLLAVS GVEADDVIGT LAREAEKAGR PVLISTGDKD MAQLVTPNIT
150
151
LINTMTNTIL GPEEVVNKYG VPPELIIDFL ALMGDSSDNI PGVPGVGEKT
200
201
AQALLQGLGG LDTLYAEPEK IAGLSFRGAK TMAAKLEQNK EVAYLSYQLA
250
251
TIKTDVELEL TCEQLEVQQP AAEELLGLFK KYEFKRWTAD VEAGKWLQAK
300
301
GAKPAAKPQE TSVADEAPEV TATVISYDNY VTILDEETLK AWIAKLEKAP
350
351
VFAFDTETDS LDNISANLVG LSFAIEPGVA AYIPVAHDYL DAPDQISRER
400
401
ALELLKPLLE DEKALKVGQN LKYDRGILAN YGIELRGIAF DTMLESYILN
450
451
SVAGRHDMDS LAERWLKHKT ITFEEIAGKG KNQLTFNQIA LEEAGRYAAE
500
501
DADVTLQLHL KMWPDLQKHK GPLNVFENIE MPLVPVLSRI ERNGVKIDPK
550
551
VLHNHSEELT LRLAELEKKA HEIAGEEFNL SSTKQLQTIL FEKQGIKPLK
600
601
KTPGGAPSTS EEVLEELALD YPLPKVILEY RGLAKLKSTY TDKLPLMINP
650
651
KTGRVHTSYH QAVTATGRLS STDPNLQNIP VRNEEGRRIR QAFIAPEDYV
700
701
IVSADYSQIE LRIMAHLSRD KGLLTAFAEG KDIHRATAAE VFGLPLETVT
750
751
SEQRRSAKAI NFGLIYGMSA FGLARQLNIP RKEAQKYMDL YFERYPGVLE
800
801
YMERTRAQAK EQGYVETLDG RRLYLPDIKS SNGARRAAAE RAAINAPMQG
850
851
TAADIIKRAM IAVDAWLQAE QPRVRMIMQV HDELVFEVHK DDVDAVAKQI
900
901
HQLMENCTRL DVPLLVEVGS GENWDQAH                        
928
 

Show the unformatted sequence.

Checksums:
CRC64:DAAE1C448A59030C
MD5:b32cef3a9da05b0df90eb1895645e93a

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
DNA_pol_A 549 - 926 1D8Y A 549 - 926 Show 3D Structure View in InterPro
1D9D A 549 - 926 Show 3D Structure View in InterPro
1D9F A 549 - 926 Show 3D Structure View in InterPro
1DPI A 549 - 926 Show 3D Structure View in InterPro
1KFD A 549 - 926 Show 3D Structure View in InterPro
1KFS A 549 - 926 Show 3D Structure View in InterPro
1KLN A 549 - 926 Show 3D Structure View in InterPro
1KRP A 549 - 926 Show 3D Structure View in InterPro
1KSP A 549 - 926 Show 3D Structure View in InterPro
1QSL A 549 - 926 Show 3D Structure View in InterPro
2KFN A 549 - 926 Show 3D Structure View in InterPro
2KFZ A 549 - 926 Show 3D Structure View in InterPro
2KZM A 549 - 926 Show 3D Structure View in InterPro
2KZZ A 549 - 926 Show 3D Structure View in InterPro
DNA_pol_A_exo1 330 - 517 1D8Y A 330 - 517 Show 3D Structure View in InterPro
1D9D A 330 - 517 Show 3D Structure View in InterPro
1D9F A 330 - 517 Show 3D Structure View in InterPro
1DPI A 330 - 517 Show 3D Structure View in InterPro
1KFD A 330 - 517 Show 3D Structure View in InterPro
1KFS A 330 - 517 Show 3D Structure View in InterPro
1KLN A 330 - 517 Show 3D Structure View in InterPro
1KRP A 330 - 517 Show 3D Structure View in InterPro
1KSP A 330 - 517 Show 3D Structure View in InterPro
1QSL A 330 - 517 Show 3D Structure View in InterPro
2KFN A 330 - 517 Show 3D Structure View in InterPro
2KFZ A 330 - 517 Show 3D Structure View in InterPro
2KZM A 330 - 517 Show 3D Structure View in InterPro
2KZZ A 330 - 517 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;