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87  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: RENI_HUMAN (P00797)

Summary

This is the summary of UniProt entry RENI_HUMAN (P00797).

Description: Renin EC=3.4.23.15
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 406 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 23
Pfam A1_Propeptide 31 51
Pfam Asp 85 405
disorder n/a 239 240

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P00797. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MDGWRRMPRW GLLLLLWGSC TFGLPTDTTT FKRIFLKRMP SIRESLKERG
50
51
VDMARLGPEW SQPMKRLTLG NTTSSVILTN YMDTQYYGEI GIGTPPQTFK
100
101
VVFDTGSSNV WVPSSKCSRL YTACVYHKLF DASDSSSYKH NGTELTLRYS
150
151
TGTVSGFLSQ DIITVGGITV TQMFGEVTEM PALPFMLAEF DGVVGMGFIE
200
201
QAIGRVTPIF DNIISQGVLK EDVFSFYYNR DSENSQSLGG QIVLGGSDPQ
250
251
HYEGNFHYIN LIKTGVWQIQ MKGVSVGSST LLCEDGCLAL VDTGASYISG
300
301
STSSIEKLME ALGAKKRLFD YVVKCNEGPT LPDISFHLGG KEYTLTSADY
350
351
VFQESYSSKK LCTLAIHAMD IPPPTGPTWA LGATFIRKFY TEFDRRNNRI
400
401
GFALAR                                                
406
 

Show the unformatted sequence.

Checksums:
CRC64:5AFDF8E973B21EDA
MD5:f05292c939f84d43c4af87d94b65beca

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
A1_Propeptide 31 - 51 3VCM P 8 - 28 Jmol OpenAstexViewer
Q 8 - 28 Jmol OpenAstexViewer
4AMT A 8 - 28 Jmol OpenAstexViewer
Asp 237 - 405 3O9L B 171 - 339 Jmol OpenAstexViewer
D 171 - 339 Jmol OpenAstexViewer
3OAD B 171 - 339 Jmol OpenAstexViewer
D 171 - 339 Jmol OpenAstexViewer
3OAG B 171 - 339 Jmol OpenAstexViewer
D 171 - 339 Jmol OpenAstexViewer
85 - 231 3O9L A 19 - 165 Jmol OpenAstexViewer
3OAD A 19 - 165 Jmol OpenAstexViewer
C 19 - 165 Jmol OpenAstexViewer
3OAG A 19 - 165 Jmol OpenAstexViewer
C 19 - 165 Jmol OpenAstexViewer
85 - 232 3O9L C 19 - 166 Jmol OpenAstexViewer
85 - 405 1BBS A 13 - 325 Jmol OpenAstexViewer
B 13 - 325 Jmol OpenAstexViewer
1BIL A 13 - 325 Jmol OpenAstexViewer
B 13 - 325 Jmol OpenAstexViewer
1BIM A 13 - 325 Jmol OpenAstexViewer
B 13 - 325 Jmol OpenAstexViewer
1HRN A 13 - 325 Jmol OpenAstexViewer
B 13 - 325 Jmol OpenAstexViewer
1RNE A 13 - 325 Jmol OpenAstexViewer
2BKS A 14 - 332 Jmol OpenAstexViewer
B 14 - 332 Jmol OpenAstexViewer
2BKT A 14 - 332 Jmol OpenAstexViewer
B 14 - 332 Jmol OpenAstexViewer
2FS4 A 14 - 332 Jmol OpenAstexViewer
B 14 - 332 Jmol OpenAstexViewer
2G1N A 14 - 334 Jmol OpenAstexViewer
B 14 - 334 Jmol OpenAstexViewer
2G1O A 14 - 334 Jmol OpenAstexViewer
B 14 - 334 Jmol OpenAstexViewer
2G1R A 14 - 334 Jmol OpenAstexViewer
B 14 - 334 Jmol OpenAstexViewer
2G1S A 14 - 334 Jmol OpenAstexViewer
B 14 - 334 Jmol OpenAstexViewer
2G1Y A 14 - 334 Jmol OpenAstexViewer
B 14 - 334 Jmol OpenAstexViewer
2G20 A 14 - 334 Jmol OpenAstexViewer
B 14 - 334 Jmol OpenAstexViewer
2G21 A 14 - 332 Jmol OpenAstexViewer
B 14 - 332 Jmol OpenAstexViewer
2G22 A 14 - 334 Jmol OpenAstexViewer
B 14 - 334 Jmol OpenAstexViewer
2G24 A 14 - 332 Jmol OpenAstexViewer
B 14 - 332 Jmol OpenAstexViewer
2G26 A 14 - 332 Jmol OpenAstexViewer
B 14 - 332 Jmol OpenAstexViewer
2G27 A 14 - 332 Jmol OpenAstexViewer
B 14 - 332 Jmol OpenAstexViewer
2I4Q A 14 - 334 Jmol OpenAstexViewer
B 14 - 334 Jmol OpenAstexViewer
2IKO A 14 - 334 Jmol OpenAstexViewer
B 14 - 334 Jmol OpenAstexViewer
2IKU A 14 - 334 Jmol OpenAstexViewer
B 14 - 334 Jmol OpenAstexViewer
2IL2 A 14 - 334 Jmol OpenAstexViewer
B 14 - 334 Jmol OpenAstexViewer
2REN A 19 - 339 Jmol OpenAstexViewer
2V0Z C 13 - 325 Jmol OpenAstexViewer
O 13 - 325 Jmol OpenAstexViewer
2V10 C 19 - 339 Jmol OpenAstexViewer
O 19 - 339 Jmol OpenAstexViewer
2V11 C 19 - 339 Jmol OpenAstexViewer
O 19 - 339 Jmol OpenAstexViewer
2V12 C 19 - 339 Jmol OpenAstexViewer
O 19 - 339 Jmol OpenAstexViewer
2V13 A 19 - 339 Jmol OpenAstexViewer
2V16 C 13 - 325 Jmol OpenAstexViewer
O 13 - 325 Jmol OpenAstexViewer
2X0B A 14 - 332 Jmol OpenAstexViewer
C 14 - 332 Jmol OpenAstexViewer
E 14 - 332 Jmol OpenAstexViewer
G 14 - 332 Jmol OpenAstexViewer
3D91 A 19 - 339 Jmol OpenAstexViewer
B 19 - 339 Jmol OpenAstexViewer
3G6Z A 19 - 339 Jmol OpenAstexViewer
B 19 - 339 Jmol OpenAstexViewer
3G70 A 19 - 339 Jmol OpenAstexViewer
B 19 - 339 Jmol OpenAstexViewer
3G72 A 19 - 339 Jmol OpenAstexViewer
B 19 - 339 Jmol OpenAstexViewer
3GW5 A 19 - 339 Jmol OpenAstexViewer
B 19 - 339 Jmol OpenAstexViewer
3K1W A 19 - 339 Jmol OpenAstexViewer
B 19 - 339 Jmol OpenAstexViewer
3KM4 A 19 - 339 Jmol OpenAstexViewer
B 19 - 339 Jmol OpenAstexViewer
3OOT A 13 - 325 Jmol OpenAstexViewer
B 13 - 325 Jmol OpenAstexViewer
3OQF A 13 - 325 Jmol OpenAstexViewer
B 13 - 325 Jmol OpenAstexViewer
3OQK A 13 - 325 Jmol OpenAstexViewer
B 13 - 325 Jmol OpenAstexViewer
3OWN A 16 - 336 Jmol OpenAstexViewer
B 16 - 336 Jmol OpenAstexViewer
3Q3T A 13 - 325 Jmol OpenAstexViewer
B 13 - 325 Jmol OpenAstexViewer
3Q4B A 13 - 325 Jmol OpenAstexViewer
B 13 - 325 Jmol OpenAstexViewer
3Q5H A 13 - 325 Jmol OpenAstexViewer
B 13 - 325 Jmol OpenAstexViewer
3SFC A 13 - 325 Jmol OpenAstexViewer
B 13 - 325 Jmol OpenAstexViewer
3VCM A 13 - 325 Jmol OpenAstexViewer
B 13 - 325 Jmol OpenAstexViewer
3VSW A 19 - 339 Jmol OpenAstexViewer
B 19 - 339 Jmol OpenAstexViewer
3VSX A 19 - 339 Jmol OpenAstexViewer
B 19 - 339 Jmol OpenAstexViewer
3VUC A 19 - 339 Jmol OpenAstexViewer
B 19 - 339 Jmol OpenAstexViewer
3VYD A 19 - 339 Jmol OpenAstexViewer
B 19 - 339 Jmol OpenAstexViewer
3VYE A 19 - 339 Jmol OpenAstexViewer
B 19 - 339 Jmol OpenAstexViewer
3VYF A 19 - 339 Jmol OpenAstexViewer
B 19 - 339 Jmol OpenAstexViewer
4AMT A 62 - 382 Jmol OpenAstexViewer
4GJ5 A 13 - 325 Jmol OpenAstexViewer
B 13 - 325 Jmol OpenAstexViewer
4GJ6 A 13 - 325 Jmol OpenAstexViewer
B 13 - 325 Jmol OpenAstexViewer
4GJ7 A 13 - 325 Jmol OpenAstexViewer
B 13 - 325 Jmol OpenAstexViewer
4GJ8 A 13 - 325 Jmol OpenAstexViewer
B 13 - 325 Jmol OpenAstexViewer
4GJ9 A 13 - 325 Jmol OpenAstexViewer
B 13 - 325 Jmol OpenAstexViewer
4GJA A 13 - 325 Jmol OpenAstexViewer
B 13 - 325 Jmol OpenAstexViewer
4GJB A 13 - 325 Jmol OpenAstexViewer
B 13 - 325 Jmol OpenAstexViewer
4GJC A 13 - 325 Jmol OpenAstexViewer
B 13 - 325 Jmol OpenAstexViewer
4GJD A 13 - 325 Jmol OpenAstexViewer
B 13 - 325 Jmol OpenAstexViewer
4PYV A 13 - 325 Jmol OpenAstexViewer
B 13 - 325 Jmol OpenAstexViewer
4Q1N A 13 - 325 Jmol OpenAstexViewer
B 13 - 325 Jmol OpenAstexViewer
4RYC A 13 - 325 Jmol OpenAstexViewer
B 13 - 325 Jmol OpenAstexViewer
4RYG A 13 - 325 Jmol OpenAstexViewer
B 13 - 325 Jmol OpenAstexViewer
4RZ1 A 13 - 325 Jmol OpenAstexViewer
B 13 - 325 Jmol OpenAstexViewer
4S1G A 85 - 405 Jmol OpenAstexViewer
B 85 - 405 Jmol OpenAstexViewer
4XX3 A 85 - 405 Jmol OpenAstexViewer
B 85 - 405 Jmol OpenAstexViewer
4XX4 A 85 - 405 Jmol OpenAstexViewer
B 85 - 405 Jmol OpenAstexViewer
5KOQ A 19 - 339 Jmol OpenAstexViewer
B 19 - 339 Jmol OpenAstexViewer
5KOS A 19 - 339 Jmol OpenAstexViewer
B 19 - 339 Jmol OpenAstexViewer
5KOT A 19 - 339 Jmol OpenAstexViewer
B 19 - 339 Jmol OpenAstexViewer
5SXN A 19 - 339 Jmol OpenAstexViewer
B 19 - 339 Jmol OpenAstexViewer
5SY2 A 19 - 339 Jmol OpenAstexViewer
B 19 - 339 Jmol OpenAstexViewer
5SY3 A 19 - 339 Jmol OpenAstexViewer
B 19 - 339 Jmol OpenAstexViewer
5SZ9 A 19 - 339 Jmol OpenAstexViewer
B 19 - 339 Jmol OpenAstexViewer
5T4S A 19 - 339 Jmol OpenAstexViewer
B 19 - 339 Jmol OpenAstexViewer
5TMG A 19 - 339 Jmol OpenAstexViewer
B 19 - 339 Jmol OpenAstexViewer
5TMK A 19 - 339 Jmol OpenAstexViewer
B 19 - 339 Jmol OpenAstexViewer
5V8V A 85 - 405 Jmol OpenAstexViewer
B 85 - 405 Jmol OpenAstexViewer
5VPM A 16 - 336 Jmol OpenAstexViewer
B 16 - 336 Jmol OpenAstexViewer
5VRP A 85 - 405 Jmol OpenAstexViewer
B 85 - 405 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.