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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: HIS2_YEAST (P00815)

Summary

This is the summary of UniProt entry HIS2_YEAST (P00815).

Description: Histidine biosynthesis trifunctional protein {ECO:0000305} Phosphoribosyl-AMP cyclohydrolase Phosphoribosyl-ATP pyrophosphohydrolase Histidinol dehydrogenase
Source organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (NCBI taxonomy ID 559292)
Length: 799 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam PRA-CH 165 239
Pfam PRA-PH 245 328
disorder n/a 328 330
disorder n/a 338 347
disorder n/a 354 355
Pfam Histidinol_dh 374 788
low_complexity n/a 542 554

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P00815. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MVLPILPLID DLASWNSKKE YVSLVGQVLL DGSSLSNEEI LQFSKEEEVP
50
51
LVALSLPSGK FSDDEIIAFL NNGVSSLFIA SQDAKTAEHL VEQLNVPKER
100
101
VVVEENGVFS NQFMVKQKFS QDKIVSIKKL SKDMLTKEVL GEVRTDRPDG
150
151
LYTTLVVDQY ERCLGLVYSS KKSIAKAIDL GRGVYYSRSR NEIWIKGETS
200
201
GNGQKLLQIS TDCDSDALKF IVEQENVGFC HLETMSCFGE FKHGLVGLES
250
251
LLKQRLQDAP EESYTRRLFN DSALLDAKIK EEAEELTEAK GKKELSWEAA
300
301
DLFYFALAKL VANDVSLKDV ENNLNMKHLK VTRRKGDAKP KFVGQPKAEE
350
351
EKLTGPIHLD VVKASDKVGV QKALSRPIQK TSEIMHLVNP IIENVRDKGN
400
401
SALLEYTEKF DGVKLSNPVL NAPFPEEYFE GLTEEMKEAL DLSIENVRKF
450
451
HAAQLPTETL EVETQPGVLC SRFPRPIEKV GLYIPGGTAI LPSTALMLGV
500
501
PAQVAQCKEI VFASPPRKSD GKVSPEVVYV AEKVGASKIV LAGGAQAVAA
550
551
MAYGTETIPK VDKILGPGNQ FVTAAKMYVQ NDTQALCSID MPAGPSEVLV
600
601
IADEDADVDF VASDLLSQAE HGIDSQVILV GVNLSEKKIQ EIQDAVHNQA
650
651
LQLPRVDIVR KCIAHSTIVL CDGYEEALEM SNQYAPEHLI LQIANANDYV
700
701
KLVDNAGSVF VGAYTPESCG DYSSGTNHTL PTYGYARQYS GANTATFQKF
750
751
ITAQNITPEG LENIGRAVMC VAKKEGLDGH RNAVKIRMSK LGLIPKDFQ 
799
 

Show the unformatted sequence.

Checksums:
CRC64:0B82D289BEAB754D
MD5:9de3f6338c64245ef1fc3a69aabfafdd

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;