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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: COLI_HUMAN (P01189)

Summary

This is the summary of UniProt entry COLI_HUMAN (P01189).

Description: Pro-opiomelanocortin
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 267 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 26
low_complexity n/a 11 18
Pfam NPP 27 70
disorder n/a 57 75
Pfam ACTH_domain 74 91
disorder n/a 88 148
low_complexity n/a 92 99
Pfam ACTH_domain 136 155
low_complexity n/a 147 159
disorder n/a 150 216
low_complexity n/a 188 204
Pfam ACTH_domain 218 236
disorder n/a 220 228
disorder n/a 232 242
Pfam Op_neuropeptide 237 264

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P01189. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPRSCCSRSG ALLLALLLQA SMEVRGWCLE SSQCQDLTTE SNLLECIRAC
50
51
KPDLSAETPM FPGNGDEQPL TENPRKYVMG HFRWDRFGRR NSSSSGSSGA
100
101
GQKREDVSAG EDCGPLPEGG PEPRSDGAKP GPREGKRSYS MEHFRWGKPV
150
151
GKKRRPVKVY PNGAEDESAE AFPLEFKREL TGQRLREGDG PDGPADDGAG
200
201
AQADLEHSLL VAAEKKDEGP YRMEHFRWGS PPKDKRYGGF MTSEKSQTPL
250
251
VTLFKNAIIK NAYKKGE                                    
267
 

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Checksums:
CRC64:B927323474A67536
MD5:e0b569efb89bfd5976b63eb488ed6000

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
ACTH_domain 138 - 143 4XNH F 1 - 6 Show 3D Structure View in InterPro
4XPD F 1 - 6 Show 3D Structure View in InterPro
4Y49 E 1 - 6 Show 3D Structure View in InterPro
K 1 - 6 Show 3D Structure View in InterPro
Q 1 - 6 Show 3D Structure View in InterPro
Op_neuropeptide 237 - 264 6TUB A 1 - 28 Show 3D Structure View in InterPro
B 1 - 28 Show 3D Structure View in InterPro
C 1 - 28 Show 3D Structure View in InterPro
D 1 - 28 Show 3D Structure View in InterPro
E 1 - 28 Show 3D Structure View in InterPro
F 1 - 28 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;