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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TNFB_HUMAN (P01374)

Summary

This is the summary of UniProt entry TNFB_HUMAN (P01374).

Description: Lymphotoxin-alpha
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 205 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 34
low_complexity n/a 13 39
disorder n/a 40 44
disorder n/a 51 53
Pfam TNF 77 205

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P01374. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MTPPERLFLP RVCGTTLHLL LLGLLLVLLP GAQGLPGVGL TPSAAQTARQ
50
51
HPKMHLAHST LKPAAHLIGD PSKQNSLLWR ANTDRAFLQD GFSLSNNSLL
100
101
VPTSGIYFVY SQVVFSGKAY SPKATSSPLY LAHEVQLFSS QYPFHVPLLS
150
151
SQKMVYPGLQ EPWLHSMYHG AAFQLTQGDQ LSTHTDGIPH LVLSPSTVFF
200
201
GAFAL                                                 
205
 

Show the unformatted sequence.

Checksums:
CRC64:1BBD5E7D496A3A82
MD5:46a0d9b1f95e6f298fb7dba0a6334e2d

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
TNF 77 - 205 1TNR A 43 - 171 Jmol OpenAstexViewer
4MXV A 43 - 171 Jmol OpenAstexViewer
B 43 - 171 Jmol OpenAstexViewer
D 43 - 171 Jmol OpenAstexViewer
4MXW A 77 - 205 Jmol OpenAstexViewer
X 77 - 205 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.