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23  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TNFA_HUMAN (P01375)

Summary

This is the summary of UniProt entry TNFA_HUMAN (P01375).

Description: Tumor necrosis factor
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 233 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 13 19
transmembrane n/a 30 55
low_complexity n/a 30 38
disorder n/a 85 92
Pfam TNF 102 233

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P01375. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSTESMIRDV ELAEEALPKK TGGPQGSRRC LFLSLFSFLI VAGATTLFCL
50
51
LHFGVIGPQR EEFPRDLSLI SPLAQAVRSS SRTPSDKPVA HVVANPQAEG
100
101
QLQWLNRRAN ALLANGVELR DNQLVVPSEG LYLIYSQVLF KGQGCPSTHV
150
151
LLTHTISRIA VSYQTKVNLL SAIKSPCQRE TPEGAEAKPW YEPIYLGGVF
200
201
QLEKGDRLSA EINRPDYLDF AESGQVYFGI IAL                  
233
 

Show the unformatted sequence.

Checksums:
CRC64:3DF90F96C9031FFE
MD5:60ada54e69e411bcf6b08e9dacff7a48

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
TNF 102 - 233 1A8M A 26 - 157 Jmol OpenAstexViewer
B 26 - 157 Jmol OpenAstexViewer
C 26 - 157 Jmol OpenAstexViewer
1TNF A 26 - 157 Jmol OpenAstexViewer
B 26 - 157 Jmol OpenAstexViewer
C 26 - 157 Jmol OpenAstexViewer
2AZ5 A 26 - 157 Jmol OpenAstexViewer
B 26 - 157 Jmol OpenAstexViewer
C 26 - 157 Jmol OpenAstexViewer
D 26 - 157 Jmol OpenAstexViewer
2E7A A 26 - 157 Jmol OpenAstexViewer
B 26 - 157 Jmol OpenAstexViewer
C 26 - 157 Jmol OpenAstexViewer
2TUN A 26 - 157 Jmol OpenAstexViewer
B 26 - 157 Jmol OpenAstexViewer
C 26 - 157 Jmol OpenAstexViewer
D 26 - 157 Jmol OpenAstexViewer
E 26 - 157 Jmol OpenAstexViewer
F 26 - 157 Jmol OpenAstexViewer
2ZJC A 26 - 157 Jmol OpenAstexViewer
B 26 - 157 Jmol OpenAstexViewer
C 26 - 157 Jmol OpenAstexViewer
2ZPX A 26 - 157 Jmol OpenAstexViewer
B 26 - 157 Jmol OpenAstexViewer
C 26 - 157 Jmol OpenAstexViewer
3ALQ A 26 - 157 Jmol OpenAstexViewer
B 26 - 157 Jmol OpenAstexViewer
C 26 - 157 Jmol OpenAstexViewer
D 26 - 157 Jmol OpenAstexViewer
E 26 - 157 Jmol OpenAstexViewer
F 26 - 157 Jmol OpenAstexViewer
3IT8 A 26 - 157 Jmol OpenAstexViewer
B 26 - 157 Jmol OpenAstexViewer
C 26 - 157 Jmol OpenAstexViewer
G 26 - 157 Jmol OpenAstexViewer
H 26 - 157 Jmol OpenAstexViewer
I 26 - 157 Jmol OpenAstexViewer
3L9J T 26 - 157 Jmol OpenAstexViewer
3WD5 A 26 - 157 Jmol OpenAstexViewer
4G3Y C 26 - 157 Jmol OpenAstexViewer
4TSV A 26 - 157 Jmol OpenAstexViewer
4TWT A 26 - 157 Jmol OpenAstexViewer
B 26 - 157 Jmol OpenAstexViewer
C 26 - 157 Jmol OpenAstexViewer
D 26 - 157 Jmol OpenAstexViewer
5M2I A 26 - 157 Jmol OpenAstexViewer
B 26 - 157 Jmol OpenAstexViewer
C 26 - 157 Jmol OpenAstexViewer
D 26 - 157 Jmol OpenAstexViewer
E 26 - 157 Jmol OpenAstexViewer
F 26 - 157 Jmol OpenAstexViewer
5M2J A 26 - 157 Jmol OpenAstexViewer
5M2M A 26 - 157 Jmol OpenAstexViewer
B 26 - 157 Jmol OpenAstexViewer
C 26 - 157 Jmol OpenAstexViewer
G 26 - 157 Jmol OpenAstexViewer
I 26 - 157 Jmol OpenAstexViewer
M 26 - 157 Jmol OpenAstexViewer
5MU8 a 26 - 157 Jmol OpenAstexViewer
A 26 - 157 Jmol OpenAstexViewer
B 26 - 157 Jmol OpenAstexViewer
b 26 - 157 Jmol OpenAstexViewer
c 26 - 157 Jmol OpenAstexViewer
C 26 - 157 Jmol OpenAstexViewer
d 26 - 157 Jmol OpenAstexViewer
D 26 - 157 Jmol OpenAstexViewer
e 26 - 157 Jmol OpenAstexViewer
F 26 - 157 Jmol OpenAstexViewer
f 26 - 157 Jmol OpenAstexViewer
g 26 - 157 Jmol OpenAstexViewer
G 26 - 157 Jmol OpenAstexViewer
H 26 - 157 Jmol OpenAstexViewer
h 26 - 157 Jmol OpenAstexViewer
I 26 - 157 Jmol OpenAstexViewer
i 26 - 157 Jmol OpenAstexViewer
j 26 - 157 Jmol OpenAstexViewer
J 26 - 157 Jmol OpenAstexViewer
K 26 - 157 Jmol OpenAstexViewer
k 26 - 157 Jmol OpenAstexViewer
L 26 - 157 Jmol OpenAstexViewer
l 26 - 157 Jmol OpenAstexViewer
M 26 - 157 Jmol OpenAstexViewer
m 26 - 157 Jmol OpenAstexViewer
N 26 - 157 Jmol OpenAstexViewer
n 26 - 157 Jmol OpenAstexViewer
O 26 - 157 Jmol OpenAstexViewer
o 26 - 157 Jmol OpenAstexViewer
P 26 - 157 Jmol OpenAstexViewer
p 26 - 157 Jmol OpenAstexViewer
q 26 - 157 Jmol OpenAstexViewer
Q 26 - 157 Jmol OpenAstexViewer
r 26 - 157 Jmol OpenAstexViewer
R 26 - 157 Jmol OpenAstexViewer
S 26 - 157 Jmol OpenAstexViewer
s 26 - 157 Jmol OpenAstexViewer
T 26 - 157 Jmol OpenAstexViewer
t 26 - 157 Jmol OpenAstexViewer
u 26 - 157 Jmol OpenAstexViewer
U 26 - 157 Jmol OpenAstexViewer
v 26 - 157 Jmol OpenAstexViewer
V 26 - 157 Jmol OpenAstexViewer
W 26 - 157 Jmol OpenAstexViewer
w 26 - 157 Jmol OpenAstexViewer
X 26 - 157 Jmol OpenAstexViewer
Y 26 - 157 Jmol OpenAstexViewer
Z 26 - 157 Jmol OpenAstexViewer
5TSW A 26 - 157 Jmol OpenAstexViewer
B 26 - 157 Jmol OpenAstexViewer
C 26 - 157 Jmol OpenAstexViewer
D 26 - 157 Jmol OpenAstexViewer
E 26 - 157 Jmol OpenAstexViewer
F 26 - 157 Jmol OpenAstexViewer
5UUI A 26 - 157 Jmol OpenAstexViewer
5WUX E 26 - 157 Jmol OpenAstexViewer
F 26 - 157 Jmol OpenAstexViewer
G 26 - 157 Jmol OpenAstexViewer
5YOY A 26 - 157 Jmol OpenAstexViewer
B 26 - 157 Jmol OpenAstexViewer
C 26 - 157 Jmol OpenAstexViewer
J 26 - 157 Jmol OpenAstexViewer
K 26 - 157 Jmol OpenAstexViewer
L 26 - 157 Jmol OpenAstexViewer
6RMJ A 26 - 157 Jmol OpenAstexViewer
B 26 - 157 Jmol OpenAstexViewer
C 26 - 157 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.