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71  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CD4_HUMAN (P01730)

Summary

This is the summary of UniProt entry CD4_HUMAN (P01730).

Description: T-cell surface glycoprotein CD4
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 458 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 25
low_complexity n/a 10 22
Pfam ig 24 123
disorder n/a 72 75
disorder n/a 79 82
Pfam C2-set 125 203
disorder n/a 147 159
Pfam CD4-extracel 206 316
Pfam C2-set 317 390
transmembrane n/a 397 420
low_complexity n/a 398 418
Pfam Tcell_CD4_C 425 453

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P01730. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MNRGVPFRHL LLVLQLALLP AATQGKKVVL GKKGDTVELT CTASQKKSIQ
50
51
FHWKNSNQIK ILGNQGSFLT KGPSKLNDRA DSRRSLWDQG NFPLIIKNLK
100
101
IEDSDTYICE VEDQKEEVQL LVFGLTANSD THLLQGQSLT LTLESPPGSS
150
151
PSVQCRSPRG KNIQGGKTLS VSQLELQDSG TWTCTVLQNQ KKVEFKIDIV
200
201
VLAFQKASSI VYKKEGEQVE FSFPLAFTVE KLTGSGELWW QAERASSSKS
250
251
WITFDLKNKE VSVKRVTQDP KLQMGKKLPL HLTLPQALPQ YAGSGNLTLA
300
301
LEAKTGKLHQ EVNLVVMRAT QLQKNLTCEV WGPTSPKLML SLKLENKEAK
350
351
VSKREKAVWV LNPEAGMWQC LLSDSGQVLL ESNIKVLPTW STPVQPMALI
400
401
VLGGVAGLLL FIGLGIFFCV RCRHRRRQAE RMSQIKRLLS EKKTCQCPHR
450
451
FQKTCSPI                                              
458
 

Show the unformatted sequence.

Checksums:
CRC64:20ED893F9E56D236
MD5:91ad571225fa48d4b2c4698eadd20e4a

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
C2-set 125 - 199 5CAY B 100 - 174 Show 3D Structure View in InterPro
125 - 200 2B4C C 100 - 175 Show 3D Structure View in InterPro
3JCB D 100 - 175 Show 3D Structure View in InterPro
3JCC D 100 - 175 Show 3D Structure View in InterPro
4JM2 F 100 - 175 Show 3D Structure View in InterPro
4R2G B 100 - 175 Show 3D Structure View in InterPro
F 100 - 175 Show 3D Structure View in InterPro
L 100 - 175 Show 3D Structure View in InterPro
125 - 201 3LQA C 100 - 176 Show 3D Structure View in InterPro
4H8W C 100 - 176 Show 3D Structure View in InterPro
4R2G H 100 - 176 Show 3D Structure View in InterPro
5VN3 C 100 - 176 Show 3D Structure View in InterPro
E 100 - 176 Show 3D Structure View in InterPro
F 100 - 176 Show 3D Structure View in InterPro
6MEO A 100 - 176 Show 3D Structure View in InterPro
125 - 202 4P9H C 100 - 177 Show 3D Structure View in InterPro
6L1Y C 100 - 177 Show 3D Structure View in InterPro
125 - 203 1CDH A 100 - 178 Show 3D Structure View in InterPro
1CDI A 100 - 178 Show 3D Structure View in InterPro
1CDJ A 100 - 178 Show 3D Structure View in InterPro
1CDU A 100 - 178 Show 3D Structure View in InterPro
1CDY A 100 - 178 Show 3D Structure View in InterPro
1G9M C 100 - 178 Show 3D Structure View in InterPro
1G9N C 100 - 178 Show 3D Structure View in InterPro
1GC1 C 100 - 178 Show 3D Structure View in InterPro
1JL4 D 100 - 178 Show 3D Structure View in InterPro
1RZJ C 100 - 178 Show 3D Structure View in InterPro
1RZK C 100 - 178 Show 3D Structure View in InterPro
1WIO A 100 - 178 Show 3D Structure View in InterPro
B 100 - 178 Show 3D Structure View in InterPro
1WIP A 100 - 178 Show 3D Structure View in InterPro
B 100 - 178 Show 3D Structure View in InterPro
1WIQ A 100 - 178 Show 3D Structure View in InterPro
B 100 - 178 Show 3D Structure View in InterPro
2NXY B 1100 - 1178 Show 3D Structure View in InterPro
2NXZ B 1100 - 1178 Show 3D Structure View in InterPro
2NY0 B 1100 - 1178 Show 3D Structure View in InterPro
2NY1 B 1100 - 1178 Show 3D Structure View in InterPro
2NY2 B 1100 - 1178 Show 3D Structure View in InterPro
2NY3 B 1100 - 1178 Show 3D Structure View in InterPro
2NY4 B 1100 - 1178 Show 3D Structure View in InterPro
2NY5 C 1100 - 1178 Show 3D Structure View in InterPro
2NY6 B 1100 - 1178 Show 3D Structure View in InterPro
2QAD B 100 - 178 Show 3D Structure View in InterPro
F 100 - 178 Show 3D Structure View in InterPro
3CD4 A 100 - 178 Show 3D Structure View in InterPro
3J70 C 100 - 178 Show 3D Structure View in InterPro
O 100 - 178 Show 3D Structure View in InterPro
T 100 - 178 Show 3D Structure View in InterPro
3JWD C 1100 - 1178 Show 3D Structure View in InterPro
D 1100 - 1178 Show 3D Structure View in InterPro
3JWO C 1100 - 1178 Show 3D Structure View in InterPro
3O2D A 100 - 178 Show 3D Structure View in InterPro
3S4S G 100 - 178 Show 3D Structure View in InterPro
H 100 - 178 Show 3D Structure View in InterPro
3S5L G 100 - 178 Show 3D Structure View in InterPro
H 100 - 178 Show 3D Structure View in InterPro
3T0E E 100 - 178 Show 3D Structure View in InterPro
4Q6I C 100 - 178 Show 3D Structure View in InterPro
I 100 - 178 Show 3D Structure View in InterPro
J 100 - 178 Show 3D Structure View in InterPro
K 100 - 178 Show 3D Structure View in InterPro
4R4H B 100 - 178 Show 3D Structure View in InterPro
4RQS B 100 - 178 Show 3D Structure View in InterPro
5A7X B 100 - 178 Show 3D Structure View in InterPro
F 100 - 178 Show 3D Structure View in InterPro
J 100 - 178 Show 3D Structure View in InterPro
5A8H B 100 - 178 Show 3D Structure View in InterPro
H 100 - 178 Show 3D Structure View in InterPro
N 100 - 178 Show 3D Structure View in InterPro
5U1F M 1100 - 1178 Show 3D Structure View in InterPro
6MET A 100 - 178 Show 3D Structure View in InterPro
317 - 388 1WIO A 292 - 363 Show 3D Structure View in InterPro
B 292 - 363 Show 3D Structure View in InterPro
1WIP A 292 - 363 Show 3D Structure View in InterPro
B 292 - 363 Show 3D Structure View in InterPro
1WIQ A 292 - 363 Show 3D Structure View in InterPro
B 292 - 363 Show 3D Structure View in InterPro
3T0E E 292 - 363 Show 3D Structure View in InterPro
5U1F M 1292 - 1363 Show 3D Structure View in InterPro
6MET A 292 - 363 Show 3D Structure View in InterPro
CD4-extracel 206 - 207 4Q6I C 181 - 182 Show 3D Structure View in InterPro
I 181 - 182 Show 3D Structure View in InterPro
J 181 - 182 Show 3D Structure View in InterPro
K 181 - 182 Show 3D Structure View in InterPro
206 - 208 3JWD C 1181 - 1183 Show 3D Structure View in InterPro
D 1181 - 1183 Show 3D Structure View in InterPro
3JWO C 1181 - 1183 Show 3D Structure View in InterPro
206 - 316 1WIO A 181 - 291 Show 3D Structure View in InterPro
B 181 - 291 Show 3D Structure View in InterPro
1WIP A 181 - 291 Show 3D Structure View in InterPro
B 181 - 291 Show 3D Structure View in InterPro
1WIQ A 181 - 291 Show 3D Structure View in InterPro
B 181 - 291 Show 3D Structure View in InterPro
3T0E E 181 - 291 Show 3D Structure View in InterPro
5U1F M 1181 - 1291 Show 3D Structure View in InterPro
6MET A 181 - 291 Show 3D Structure View in InterPro
ig 26 - 120 6OPN C 1 - 95 Show 3D Structure View in InterPro
F 1 - 95 Show 3D Structure View in InterPro
I 1 - 95 Show 3D Structure View in InterPro
26 - 121 6X5B C 1 - 96 Show 3D Structure View in InterPro
G 1 - 96 Show 3D Structure View in InterPro
N 1 - 96 Show 3D Structure View in InterPro
6X5C C 1 - 96 Show 3D Structure View in InterPro
I 1 - 96 Show 3D Structure View in InterPro
J 1 - 96 Show 3D Structure View in InterPro
26 - 122 5THR I 1 - 97 Show 3D Structure View in InterPro
6CM3 G 1 - 97 Show 3D Structure View in InterPro
H 1 - 97 Show 3D Structure View in InterPro
I 1 - 97 Show 3D Structure View in InterPro
6EDU G 1 - 97 Show 3D Structure View in InterPro
H 1 - 97 Show 3D Structure View in InterPro
I 1 - 97 Show 3D Structure View in InterPro
6OPO C 1 - 97 Show 3D Structure View in InterPro
G 1 - 97 Show 3D Structure View in InterPro
N 1 - 97 Show 3D Structure View in InterPro
6OPP C 1 - 97 Show 3D Structure View in InterPro
F 1 - 97 Show 3D Structure View in InterPro
M 1 - 97 Show 3D Structure View in InterPro
6OPQ C 1 - 97 Show 3D Structure View in InterPro
I 1 - 97 Show 3D Structure View in InterPro
J 1 - 97 Show 3D Structure View in InterPro
6U0L D 1 - 97 Show 3D Structure View in InterPro
E 1 - 97 Show 3D Structure View in InterPro
F 1 - 97 Show 3D Structure View in InterPro
6U0N D 1 - 97 Show 3D Structure View in InterPro
E 1 - 97 Show 3D Structure View in InterPro
F 1 - 97 Show 3D Structure View in InterPro
26 - 123 1CDH A 1 - 98 Show 3D Structure View in InterPro
1CDI A 1 - 98 Show 3D Structure View in InterPro
1CDJ A 1 - 98 Show 3D Structure View in InterPro
1CDU A 1 - 98 Show 3D Structure View in InterPro
1CDY A 1 - 98 Show 3D Structure View in InterPro
1G9M C 1 - 98 Show 3D Structure View in InterPro
1G9N C 1 - 98 Show 3D Structure View in InterPro
1GC1 C 1 - 98 Show 3D Structure View in InterPro
1JL4 D 1 - 98 Show 3D Structure View in InterPro
1RZJ C 1 - 98 Show 3D Structure View in InterPro
1RZK C 1 - 98 Show 3D Structure View in InterPro
1WIO A 1 - 98 Show 3D Structure View in InterPro
B 1 - 98 Show 3D Structure View in InterPro
1WIP A 1 - 98 Show 3D Structure View in InterPro
B 1 - 98 Show 3D Structure View in InterPro
1WIQ A 1 - 98 Show 3D Structure View in InterPro
B 1 - 98 Show 3D Structure View in InterPro
2B4C C 1 - 98 Show 3D Structure View in InterPro
2NXY B 1001 - 1098 Show 3D Structure View in InterPro
2NXZ B 1001 - 1098 Show 3D Structure View in InterPro
2NY0 B 1001 - 1098 Show 3D Structure View in InterPro
2NY1 B 1001 - 1098 Show 3D Structure View in InterPro
2NY2 B 1001 - 1098 Show 3D Structure View in InterPro
2NY3 B 1001 - 1098 Show 3D Structure View in InterPro
2NY4 B 1001 - 1098 Show 3D Structure View in InterPro
2NY5 C 1001 - 1098 Show 3D Structure View in InterPro
2NY6 B 1001 - 1098 Show 3D Structure View in InterPro
2QAD B 1 - 98 Show 3D Structure View in InterPro
F 1 - 98 Show 3D Structure View in InterPro
3CD4 A 1 - 98 Show 3D Structure View in InterPro
3J70 C 1 - 98 Show 3D Structure View in InterPro
O 1 - 98 Show 3D Structure View in InterPro
T 1 - 98 Show 3D Structure View in InterPro
3JCB D 1 - 98 Show 3D Structure View in InterPro
3JCC D 1 - 98 Show 3D Structure View in InterPro
3JWD C 1001 - 1098 Show 3D Structure View in InterPro
D 1001 - 1098 Show 3D Structure View in InterPro
3JWO C 1001 - 1098 Show 3D Structure View in InterPro
3O2D A 1 - 98 Show 3D Structure View in InterPro
3S4S G 1 - 98 Show 3D Structure View in InterPro
H 1 - 98 Show 3D Structure View in InterPro
3S5L H 1 - 98 Show 3D Structure View in InterPro
3T0E E 1 - 98 Show 3D Structure View in InterPro
4H8W C 1 - 98 Show 3D Structure View in InterPro
4JM2 F 1 - 98 Show 3D Structure View in InterPro
4Q6I C 1 - 98 Show 3D Structure View in InterPro
I 1 - 98 Show 3D Structure View in InterPro
J 1 - 98 Show 3D Structure View in InterPro
K 1 - 98 Show 3D Structure View in InterPro
4R2G B 1 - 98 Show 3D Structure View in InterPro
F 1 - 98 Show 3D Structure View in InterPro
H 1 - 98 Show 3D Structure View in InterPro
4R4H B 1 - 98 Show 3D Structure View in InterPro
4RQS B 1 - 98 Show 3D Structure View in InterPro
5A7X B 1 - 98 Show 3D Structure View in InterPro
F 1 - 98 Show 3D Structure View in InterPro
J 1 - 98 Show 3D Structure View in InterPro
5A8H B 1 - 98 Show 3D Structure View in InterPro
H 1 - 98 Show 3D Structure View in InterPro
N 1 - 98 Show 3D Structure View in InterPro
5THR G 1 - 98 Show 3D Structure View in InterPro
H 1 - 98 Show 3D Structure View in InterPro
5U1F M 1001 - 1098 Show 3D Structure View in InterPro
5VN3 C 1 - 98 Show 3D Structure View in InterPro
E 1 - 98 Show 3D Structure View in InterPro
F 1 - 98 Show 3D Structure View in InterPro
6L1Y C 1 - 98 Show 3D Structure View in InterPro
6MEO A 1 - 98 Show 3D Structure View in InterPro
6MET A 1 - 98 Show 3D Structure View in InterPro
27 - 123 3LQA C 2 - 98 Show 3D Structure View in InterPro
3S5L G 2 - 98 Show 3D Structure View in InterPro
4P9H C 2 - 98 Show 3D Structure View in InterPro
5CAY B 2 - 98 Show 3D Structure View in InterPro
28 - 123 4R2G L 3 - 98 Show 3D Structure View in InterPro
Tcell_CD4_C 425 - 453 1Q68 A 400 - 428 Show 3D Structure View in InterPro
2KLU A 400 - 428 Show 3D Structure View in InterPro
428 - 444 1WBR A 403 - 419 Show 3D Structure View in InterPro
431 - 441 3B71 D 406 - 416 Show 3D Structure View in InterPro
E 406 - 416 Show 3D Structure View in InterPro
431 - 444 6URI D 406 - 419 Show 3D Structure View in InterPro
432 - 440 2JKR P 2 - 10 Show 3D Structure View in InterPro
Q 2 - 10 Show 3D Structure View in InterPro
2JKT P 2 - 10 Show 3D Structure View in InterPro
Q 2 - 10 Show 3D Structure View in InterPro
6QH6 Q 2 - 10 Show 3D Structure View in InterPro
6QH7 Q 2 - 10 Show 3D Structure View in InterPro
433 - 441 3B71 F 408 - 416 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;