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19  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CRYAB_HUMAN (P02511)

Summary

This is the summary of UniProt entry CRYAB_HUMAN (P02511).

Description: Alpha-crystallin B chain
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 175 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
Pfam Crystallin 1 56
Pfam HSP20 67 162
disorder n/a 109 110
disorder n/a 139 140
disorder n/a 142 175

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P02511. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MDIAIHHPWI RRPFFPFHSP SRLFDQFFGE HLLESDLFPT STSLSPFYLR
50
51
PPSFLRAPSW FDTGLSEMRL EKDRFSVNLD VKHFSPEELK VKVLGDVIEV
100
101
HGKHEERQDE HGFISREFHR KYRIPADVDP LTITSSLSSD GVLTVNGPRK
150
151
QVSGPERTIP ITREEKPAVT AAPKK                           
175
 

Show the unformatted sequence.

Checksums:
CRC64:AE08BED46B7849CB
MD5:d9c165876239ac8847787ecb41c856f9

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Crystallin 1 - 56 2YGD A 1 - 56 Show 3D Structure View in InterPro
B 1 - 56 Show 3D Structure View in InterPro
C 1 - 56 Show 3D Structure View in InterPro
D 1 - 56 Show 3D Structure View in InterPro
E 1 - 56 Show 3D Structure View in InterPro
F 1 - 56 Show 3D Structure View in InterPro
G 1 - 56 Show 3D Structure View in InterPro
H 1 - 56 Show 3D Structure View in InterPro
I 1 - 56 Show 3D Structure View in InterPro
J 1 - 56 Show 3D Structure View in InterPro
K 1 - 56 Show 3D Structure View in InterPro
L 1 - 56 Show 3D Structure View in InterPro
M 1 - 56 Show 3D Structure View in InterPro
N 1 - 56 Show 3D Structure View in InterPro
O 1 - 56 Show 3D Structure View in InterPro
P 1 - 56 Show 3D Structure View in InterPro
Q 1 - 56 Show 3D Structure View in InterPro
R 1 - 56 Show 3D Structure View in InterPro
S 1 - 56 Show 3D Structure View in InterPro
T 1 - 56 Show 3D Structure View in InterPro
U 1 - 56 Show 3D Structure View in InterPro
V 1 - 56 Show 3D Structure View in InterPro
W 1 - 56 Show 3D Structure View in InterPro
X 1 - 56 Show 3D Structure View in InterPro
3J07 A 1 - 56 Show 3D Structure View in InterPro
B 1 - 56 Show 3D Structure View in InterPro
C 1 - 56 Show 3D Structure View in InterPro
D 1 - 56 Show 3D Structure View in InterPro
E 1 - 56 Show 3D Structure View in InterPro
F 1 - 56 Show 3D Structure View in InterPro
G 1 - 56 Show 3D Structure View in InterPro
H 1 - 56 Show 3D Structure View in InterPro
I 1 - 56 Show 3D Structure View in InterPro
J 1 - 56 Show 3D Structure View in InterPro
K 1 - 56 Show 3D Structure View in InterPro
L 1 - 56 Show 3D Structure View in InterPro
M 1 - 56 Show 3D Structure View in InterPro
N 1 - 56 Show 3D Structure View in InterPro
O 1 - 56 Show 3D Structure View in InterPro
P 1 - 56 Show 3D Structure View in InterPro
Q 1 - 56 Show 3D Structure View in InterPro
R 1 - 56 Show 3D Structure View in InterPro
S 1 - 56 Show 3D Structure View in InterPro
T 1 - 56 Show 3D Structure View in InterPro
U 1 - 56 Show 3D Structure View in InterPro
V 1 - 56 Show 3D Structure View in InterPro
W 1 - 56 Show 3D Structure View in InterPro
X 1 - 56 Show 3D Structure View in InterPro
40 - 44 5VVV D 40 - 44 Show 3D Structure View in InterPro
41 - 42 5VVV B 41 - 42 Show 3D Structure View in InterPro
HSP20 156 - 162 4M5S B 156 - 162 Show 3D Structure View in InterPro
4M5T B 156 - 162 Show 3D Structure View in InterPro
D 156 - 162 Show 3D Structure View in InterPro
F 156 - 162 Show 3D Structure View in InterPro
H 156 - 162 Show 3D Structure View in InterPro
67 - 150 2WJ7 A 4 - 87 Show 3D Structure View in InterPro
C 4 - 87 Show 3D Structure View in InterPro
2Y1Z B 67 - 150 Show 3D Structure View in InterPro
67 - 151 2Y1Z A 67 - 151 Show 3D Structure View in InterPro
2Y22 A 67 - 151 Show 3D Structure View in InterPro
67 - 152 2N0K A 67 - 152 Show 3D Structure View in InterPro
B 67 - 152 Show 3D Structure View in InterPro
6BP9 A 67 - 152 Show 3D Structure View in InterPro
B 67 - 152 Show 3D Structure View in InterPro
67 - 162 2YGD A 67 - 162 Show 3D Structure View in InterPro
B 67 - 162 Show 3D Structure View in InterPro
C 67 - 162 Show 3D Structure View in InterPro
D 67 - 162 Show 3D Structure View in InterPro
E 67 - 162 Show 3D Structure View in InterPro
F 67 - 162 Show 3D Structure View in InterPro
G 67 - 162 Show 3D Structure View in InterPro
H 67 - 162 Show 3D Structure View in InterPro
I 67 - 162 Show 3D Structure View in InterPro
J 67 - 162 Show 3D Structure View in InterPro
K 67 - 162 Show 3D Structure View in InterPro
L 67 - 162 Show 3D Structure View in InterPro
M 67 - 162 Show 3D Structure View in InterPro
N 67 - 162 Show 3D Structure View in InterPro
O 67 - 162 Show 3D Structure View in InterPro
P 67 - 162 Show 3D Structure View in InterPro
Q 67 - 162 Show 3D Structure View in InterPro
R 67 - 162 Show 3D Structure View in InterPro
S 67 - 162 Show 3D Structure View in InterPro
T 67 - 162 Show 3D Structure View in InterPro
U 67 - 162 Show 3D Structure View in InterPro
V 67 - 162 Show 3D Structure View in InterPro
W 67 - 162 Show 3D Structure View in InterPro
X 67 - 162 Show 3D Structure View in InterPro
3J07 A 67 - 162 Show 3D Structure View in InterPro
B 67 - 162 Show 3D Structure View in InterPro
C 67 - 162 Show 3D Structure View in InterPro
D 67 - 162 Show 3D Structure View in InterPro
E 67 - 162 Show 3D Structure View in InterPro
F 67 - 162 Show 3D Structure View in InterPro
G 67 - 162 Show 3D Structure View in InterPro
H 67 - 162 Show 3D Structure View in InterPro
I 67 - 162 Show 3D Structure View in InterPro
J 67 - 162 Show 3D Structure View in InterPro
K 67 - 162 Show 3D Structure View in InterPro
L 67 - 162 Show 3D Structure View in InterPro
M 67 - 162 Show 3D Structure View in InterPro
N 67 - 162 Show 3D Structure View in InterPro
O 67 - 162 Show 3D Structure View in InterPro
P 67 - 162 Show 3D Structure View in InterPro
Q 67 - 162 Show 3D Structure View in InterPro
R 67 - 162 Show 3D Structure View in InterPro
S 67 - 162 Show 3D Structure View in InterPro
T 67 - 162 Show 3D Structure View in InterPro
U 67 - 162 Show 3D Structure View in InterPro
V 67 - 162 Show 3D Structure View in InterPro
W 67 - 162 Show 3D Structure View in InterPro
X 67 - 162 Show 3D Structure View in InterPro
68 - 151 4M5T E 68 - 151 Show 3D Structure View in InterPro
68 - 152 4M5T A 68 - 152 Show 3D Structure View in InterPro
C 68 - 152 Show 3D Structure View in InterPro
G 68 - 152 Show 3D Structure View in InterPro
68 - 153 4M5S A 68 - 153 Show 3D Structure View in InterPro
68 - 162 3L1G A 68 - 162 Show 3D Structure View in InterPro
69 - 148 2Y22 D 69 - 148 Show 3D Structure View in InterPro
69 - 150 2KLR A 69 - 150 Show 3D Structure View in InterPro
B 69 - 150 Show 3D Structure View in InterPro
73 - 149 2Y22 E 73 - 149 Show 3D Structure View in InterPro
73 - 150 2Y1Y A 73 - 150 Show 3D Structure View in InterPro
74 - 149 2Y22 B 74 - 149 Show 3D Structure View in InterPro
75 - 146 2WJ7 B 12 - 83 Show 3D Structure View in InterPro
75 - 148 2WJ7 E 12 - 85 Show 3D Structure View in InterPro
2Y22 C 75 - 148 Show 3D Structure View in InterPro
76 - 149 2Y22 F 76 - 149 Show 3D Structure View in InterPro
77 - 147 2WJ7 D 14 - 84 Show 3D Structure View in InterPro
90 - 100 3SGM A 1 - 11 Show 3D Structure View in InterPro
B 1 - 11 Show 3D Structure View in InterPro
C 1 - 11 Show 3D Structure View in InterPro
D 1 - 11 Show 3D Structure View in InterPro
3SGN A 1 - 11 Show 3D Structure View in InterPro
B 1 - 11 Show 3D Structure View in InterPro
3SGO A 1 - 11 Show 3D Structure View in InterPro
3SGP A 1 - 11 Show 3D Structure View in InterPro
B 1 - 11 Show 3D Structure View in InterPro
C 1 - 11 Show 3D Structure View in InterPro
D 1 - 11 Show 3D Structure View in InterPro
3SGR A 1 - 11 Show 3D Structure View in InterPro
B 1 - 11 Show 3D Structure View in InterPro
C 1 - 11 Show 3D Structure View in InterPro
D 1 - 11 Show 3D Structure View in InterPro
E 1 - 11 Show 3D Structure View in InterPro
F 1 - 11 Show 3D Structure View in InterPro
95 - 100 3SGS A 1 - 6 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;