Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
8  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: VTNC_HUMAN (P04004)

Summary

This is the summary of UniProt entry VTNC_HUMAN (P04004).

Description: Vitronectin
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 478 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
sig_p n/a 1 19
low_complexity n/a 2 19
Pfam Somatomedin_B 22 61
disorder n/a 62 63
disorder n/a 69 160
low_complexity n/a 118 126
Pfam Hemopexin 161 204
Pfam Hemopexin 206 252
Pfam Hemopexin 254 304
disorder n/a 333 334
disorder n/a 366 367
disorder n/a 370 393
Pfam Hemopexin 425 472

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P04004. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAPLRPLLIL ALLAWVALAD QESCKGRCTE GFNVDKKCQC DELCSYYQSC
50
51
CTDYTAECKP QVTRGDVFTM PEDEYTVYDD GEEKNNATVH EQVGGPSLTS
100
101
DLQAQSKGNP EQTPVLKPEE EAPAPEVGAS KPEGIDSRPE TLHPGRPQPP
150
151
AEEELCSGKP FDAFTDLKNG SLFAFRGQYC YELDEKAVRP GYPKLIRDVW
200
201
GIEGPIDAAF TRINCQGKTY LFKGSQYWRF EDGVLDPDYP RNISDGFDGI
250
251
PDNVDAALAL PAHSYSGRER VYFFKGKQYW EYQFQHQPSQ EECEGSSLSA
300
301
VFEHFAMMQR DSWEDIFELL FWGRTSAGTR QPQFISRDWH GVPGQVDAAM
350
351
AGRIYISGMA PRPSLAKKQR FRHRNRKGYR SQRGHSRGRN QNSRRPSRAT
400
401
WLSLFSSEES NLGANNYDDY RMDWLVPATC EPIQSVFFFS GDKYYRVNLR
450
451
TRRVDTVDPP YPRSIAQYWL GCPAPGHL                        
478
 

Show the unformatted sequence.

Checksums:
CRC64:0D6DB5591CBFEF45
MD5:7434ea9a039922713269892111f186b8

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Hemopexin 161 - 204 6O5E A 161 - 204 Show 3D Structure View in InterPro
B 161 - 204 Show 3D Structure View in InterPro
206 - 252 6O5E A 206 - 252 Show 3D Structure View in InterPro
B 206 - 252 Show 3D Structure View in InterPro
254 - 284 6O5E A 254 - 284 Show 3D Structure View in InterPro
B 254 - 284 Show 3D Structure View in InterPro
435 - 472 6O5E A 435 - 472 Show 3D Structure View in InterPro
B 435 - 472 Show 3D Structure View in InterPro
Somatomedin_B 22 - 58 1OC0 B 3 - 39 Show 3D Structure View in InterPro
22 - 60 3BT1 B 3 - 41 Show 3D Structure View in InterPro
3BT2 B 3 - 41 Show 3D Structure View in InterPro
4K24 B 3 - 41 Show 3D Structure View in InterPro
22 - 61 1S4G A 3 - 42 Show 3D Structure View in InterPro
1SSU A 3 - 42 Show 3D Structure View in InterPro
2JQ8 A 3 - 42 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;