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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ANXA1_HUMAN (P04083)

Summary

This is the summary of UniProt entry ANXA1_HUMAN (P04083).

Description: Annexin A1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 346 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 23 27
disorder n/a 29 30
disorder n/a 33 39
Pfam Annexin 46 111
disorder n/a 82 84
disorder n/a 95 96
Pfam Annexin 118 183
disorder n/a 123 125
Pfam Annexin 201 267
Pfam Annexin 277 342

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P04083. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAMVSEFLKQ AWFIENEEQE YVQTVKSSKG GPGSAVSPYP TFNPSSDVAA
50
51
LHKAIMVKGV DEATIIDILT KRNNAQRQQI KAAYLQETGK PLDETLKKAL
100
101
TGHLEEVVLA LLKTPAQFDA DELRAAMKGL GTDEDTLIEI LASRTNKEIR
150
151
DINRVYREEL KRDLAKDITS DTSGDFRNAL LSLAKGDRSE DFGVNEDLAD
200
201
SDARALYEAG ERRKGTDVNV FNTILTTRSY PQLRRVFQKY TKYSKHDMNK
250
251
VLDLELKGDI EKCLTAIVKC ATSKPAFFAE KLHQAMKGVG TRHKALIRIM
300
301
VSRSEIDMND IKAFYQKMYG ISLCQAILDE TKGDYEKILV ALCGGN    
346
 

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Checksums:
CRC64:14B42E1FA4178EC0
MD5:618e294cf1bfa1f6456b65102f7406d6

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Annexin 118 - 183 1AIN A 91 - 156 Jmol OpenAstexViewer
201 - 267 1AIN A 174 - 240 Jmol OpenAstexViewer
277 - 342 1AIN A 250 - 315 Jmol OpenAstexViewer
46 - 111 1AIN A 19 - 84 Jmol OpenAstexViewer
1BO9 A 6 - 71 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.