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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: KITH_HUMAN (P04183)

Summary

This is the summary of UniProt entry KITH_HUMAN (P04183).

Description: Thymidine kinase, cytosolic EC=2.7.1.21
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 234 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam TK 19 189
disorder n/a 200 209

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P04183. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSCINLPTVL PGSPSKTRGQ IQVILGPMFS GKSTELMRRV RRFQIAQYKC
50
51
LVIKYAKDTR YSSSFCTHDR NTMEALPACL LRDVAQEALG VAVIGIDEGQ
100
101
FFPDIVEFCE AMANAGKTVI VAALDGTFQR KPFGAILNLV PLAESVVKLT
150
151
AVCMECFREA AYTKRLGTEK EVEVIGGADK YHSVCRLCYF KKASGQPAGP
200
201
DNKENCPVPG KPGEAVAARK LFAPQQILQC SPAN                 
234
 

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Checksums:
CRC64:76901415C631EF21
MD5:5741784611e57174aa230205c76118f5

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
TK 19 - 189 1W4R A 19 - 189 Jmol OpenAstexViewer
B 19 - 189 Jmol OpenAstexViewer
C 19 - 189 Jmol OpenAstexViewer
D 19 - 189 Jmol OpenAstexViewer
E 19 - 189 Jmol OpenAstexViewer
F 19 - 189 Jmol OpenAstexViewer
G 19 - 189 Jmol OpenAstexViewer
H 19 - 189 Jmol OpenAstexViewer
1XBT A 19 - 189 Jmol OpenAstexViewer
B 19 - 189 Jmol OpenAstexViewer
C 19 - 189 Jmol OpenAstexViewer
D 19 - 189 Jmol OpenAstexViewer
E 19 - 189 Jmol OpenAstexViewer
F 19 - 189 Jmol OpenAstexViewer
G 19 - 189 Jmol OpenAstexViewer
H 19 - 189 Jmol OpenAstexViewer
2ORV A 19 - 189 Jmol OpenAstexViewer
B 19 - 189 Jmol OpenAstexViewer
2WVJ A 19 - 189 Jmol OpenAstexViewer
B 19 - 189 Jmol OpenAstexViewer
C 19 - 189 Jmol OpenAstexViewer
D 19 - 189 Jmol OpenAstexViewer
E 19 - 189 Jmol OpenAstexViewer
F 19 - 189 Jmol OpenAstexViewer
G 19 - 189 Jmol OpenAstexViewer
H 19 - 189 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.