Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
16  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ERBB2_HUMAN (P04626)

Summary

This is the summary of UniProt entry ERBB2_HUMAN (P04626).

Description: Receptor tyrosine-protein kinase erbB-2 EC=2.7.10.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 1255 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
sig_p n/a 1 21
low_complexity n/a 2 20
Pfam Recep_L_domain 52 173
disorder n/a 124 132
Pfam Furin-like 183 343
Pfam Recep_L_domain 366 486
disorder n/a 387 388
low_complexity n/a 452 466
Pfam GF_recep_IV 510 643
transmembrane n/a 654 675
low_complexity n/a 657 674
Pfam Pkinase_Tyr 720 976
disorder n/a 991 992
disorder n/a 1017 1019
disorder n/a 1029 1031
disorder n/a 1035 1185
low_complexity n/a 1043 1062
disorder n/a 1188 1255
low_complexity n/a 1198 1216

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P04626. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MELAALCRWG LLLALLPPGA ASTQVCTGTD MKLRLPASPE THLDMLRHLY
50
51
QGCQVVQGNL ELTYLPTNAS LSFLQDIQEV QGYVLIAHNQ VRQVPLQRLR
100
101
IVRGTQLFED NYALAVLDNG DPLNNTTPVT GASPGGLREL QLRSLTEILK
150
151
GGVLIQRNPQ LCYQDTILWK DIFHKNNQLA LTLIDTNRSR ACHPCSPMCK
200
201
GSRCWGESSE DCQSLTRTVC AGGCARCKGP LPTDCCHEQC AAGCTGPKHS
250
251
DCLACLHFNH SGICELHCPA LVTYNTDTFE SMPNPEGRYT FGASCVTACP
300
301
YNYLSTDVGS CTLVCPLHNQ EVTAEDGTQR CEKCSKPCAR VCYGLGMEHL
350
351
REVRAVTSAN IQEFAGCKKI FGSLAFLPES FDGDPASNTA PLQPEQLQVF
400
401
ETLEEITGYL YISAWPDSLP DLSVFQNLQV IRGRILHNGA YSLTLQGLGI
450
451
SWLGLRSLRE LGSGLALIHH NTHLCFVHTV PWDQLFRNPH QALLHTANRP
500
501
EDECVGEGLA CHQLCARGHC WGPGPTQCVN CSQFLRGQEC VEECRVLQGL
550
551
PREYVNARHC LPCHPECQPQ NGSVTCFGPE ADQCVACAHY KDPPFCVARC
600
601
PSGVKPDLSY MPIWKFPDEE GACQPCPINC THSCVDLDDK GCPAEQRASP
650
651
LTSIISAVVG ILLVVVLGVV FGILIKRRQQ KIRKYTMRRL LQETELVEPL
700
701
TPSGAMPNQA QMRILKETEL RKVKVLGSGA FGTVYKGIWI PDGENVKIPV
750
751
AIKVLRENTS PKANKEILDE AYVMAGVGSP YVSRLLGICL TSTVQLVTQL
800
801
MPYGCLLDHV RENRGRLGSQ DLLNWCMQIA KGMSYLEDVR LVHRDLAARN
850
851
VLVKSPNHVK ITDFGLARLL DIDETEYHAD GGKVPIKWMA LESILRRRFT
900
901
HQSDVWSYGV TVWELMTFGA KPYDGIPARE IPDLLEKGER LPQPPICTID
950
951
VYMIMVKCWM IDSECRPRFR ELVSEFSRMA RDPQRFVVIQ NEDLGPASPL
1000
1001
DSTFYRSLLE DDDMGDLVDA EEYLVPQQGF FCPDPAPGAG GMVHHRHRSS
1050
1051
STRSGGGDLT LGLEPSEEEA PRSPLAPSEG AGSDVFDGDL GMGAAKGLQS
1100
1101
LPTHDPSPLQ RYSEDPTVPL PSETDGYVAP LTCSPQPEYV NQPDVRPQPP
1150
1151
SPREGPLPAA RPAGATLERP KTLSPGKNGV VKDVFAFGGA VENPEYLTPQ
1200
1201
GGAAPQPHPP PAFSPAFDNL YYWDQDPPER GAPPSTFKGT PTAENPEYLG
1250
1251
LDVPV                                                 
1255
 

Show the unformatted sequence.

Checksums:
CRC64:39E9DFDA04DCF962
MD5:d89a90920775435179a0d5281a800f78

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Furin-like 183 - 204 4HRM A 161 - 182 Jmol OpenAstexViewer
183 - 213 3H3B B 161 - 191 Jmol OpenAstexViewer
4HRL C 161 - 191 Jmol OpenAstexViewer
4HRM C 161 - 191 Jmol OpenAstexViewer
183 - 214 3H3B A 161 - 192 Jmol OpenAstexViewer
183 - 343 1N8Z C 161 - 321 Jmol OpenAstexViewer
1S78 A 161 - 321 Jmol OpenAstexViewer
B 161 - 321 Jmol OpenAstexViewer
2A91 A 162 - 322 Jmol OpenAstexViewer
3BE1 A 161 - 321 Jmol OpenAstexViewer
3MZW A 161 - 321 Jmol OpenAstexViewer
3N85 A 161 - 321 Jmol OpenAstexViewer
3WLW A 161 - 321 Jmol OpenAstexViewer
B 161 - 321 Jmol OpenAstexViewer
3WSQ A 161 - 321 Jmol OpenAstexViewer
GF_recep_IV 510 - 530 2A91 A 489 - 509 Jmol OpenAstexViewer
510 - 586 1S78 A 488 - 564 Jmol OpenAstexViewer
3WLW A 488 - 564 Jmol OpenAstexViewer
B 488 - 564 Jmol OpenAstexViewer
3WSQ A 488 - 564 Jmol OpenAstexViewer
510 - 599 1S78 B 488 - 577 Jmol OpenAstexViewer
510 - 600 3MZW A 488 - 578 Jmol OpenAstexViewer
510 - 629 1N8Z C 488 - 607 Jmol OpenAstexViewer
3BE1 A 488 - 607 Jmol OpenAstexViewer
510 - 642 3N85 A 488 - 620 Jmol OpenAstexViewer
531 - 600 4HRN D 9 - 78 Jmol OpenAstexViewer
531 - 601 4HRN C 9 - 79 Jmol OpenAstexViewer
641 - 643 2JWA A 41 - 43 Jmol OpenAstexViewer
B 141 - 143 Jmol OpenAstexViewer
2KS1 A 41 - 43 Jmol OpenAstexViewer
Pkinase_Tyr 720 - 976 3PP0 A 720 - 976 Jmol OpenAstexViewer
B 720 - 976 Jmol OpenAstexViewer
3RCD A 720 - 976 Jmol OpenAstexViewer
B 720 - 976 Jmol OpenAstexViewer
C 720 - 976 Jmol OpenAstexViewer
D 720 - 976 Jmol OpenAstexViewer
Recep_L_domain 366 - 486 1N8Z C 344 - 464 Jmol OpenAstexViewer
1S78 A 344 - 464 Jmol OpenAstexViewer
B 344 - 464 Jmol OpenAstexViewer
2A91 A 345 - 465 Jmol OpenAstexViewer
3BE1 A 344 - 464 Jmol OpenAstexViewer
3MZW A 344 - 464 Jmol OpenAstexViewer
3N85 A 344 - 464 Jmol OpenAstexViewer
3WLW A 344 - 464 Jmol OpenAstexViewer
B 344 - 464 Jmol OpenAstexViewer
3WSQ A 344 - 464 Jmol OpenAstexViewer
52 - 173 1N8Z C 30 - 151 Jmol OpenAstexViewer
1S78 A 30 - 151 Jmol OpenAstexViewer
B 30 - 151 Jmol OpenAstexViewer
2A91 A 31 - 152 Jmol OpenAstexViewer
3BE1 A 30 - 151 Jmol OpenAstexViewer
3H3B A 30 - 151 Jmol OpenAstexViewer
B 30 - 151 Jmol OpenAstexViewer
3MZW A 30 - 151 Jmol OpenAstexViewer
3N85 A 30 - 151 Jmol OpenAstexViewer
3WLW A 30 - 151 Jmol OpenAstexViewer
B 30 - 151 Jmol OpenAstexViewer
3WSQ A 30 - 151 Jmol OpenAstexViewer
4HRL C 30 - 151 Jmol OpenAstexViewer
4HRM A 30 - 151 Jmol OpenAstexViewer
C 30 - 151 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.