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135  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: P53_HUMAN (P04637)

Summary

This is the summary of UniProt entry P53_HUMAN (P04637).

Description: Cellular tumor antigen p53
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 393 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 1 23
Pfam P53_TAD 6 30
disorder n/a 25 27
disorder n/a 30 31
disorder n/a 33 97
Pfam TAD2 35 59
low_complexity n/a 62 88
Pfam P53 99 289
disorder n/a 157 161
disorder n/a 174 175
disorder n/a 216 217
disorder n/a 281 329
Pfam P53_tetramer 319 358
disorder n/a 343 393

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P04637. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEEPQSDPSV EPPLSQETFS DLWKLLPENN VLSPLPSQAM DDLMLSPDDI
50
51
EQWFTEDPGP DEAPRMPEAA PPVAPAPAAP TPAAPAPAPS WPLSSSVPSQ
100
101
KTYQGSYGFR LGFLHSGTAK SVTCTYSPAL NKMFCQLAKT CPVQLWVDST
150
151
PPPGTRVRAM AIYKQSQHMT EVVRRCPHHE RCSDSDGLAP PQHLIRVEGN
200
201
LRVEYLDDRN TFRHSVVVPY EPPEVGSDCT TIHYNYMCNS SCMGGMNRRP
250
251
ILTIITLEDS SGNLLGRNSF EVRVCACPGR DRRTEEENLR KKGEPHHELP
300
301
PGSTKRALPN NTSSSPQPKK KPLDGEYFTL QIRGRERFEM FRELNEALEL
350
351
KDAQAGKEPG GSRAHSSHLK SKKGQSTSRH KKLMFKTEGP DSD       
393
 

Show the unformatted sequence.

Checksums:
CRC64:AD5C149FD8106131
MD5:c133dfce69f606f20865e9008199f852

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
P53 145 - 152 2YDR P 145 - 152 Jmol OpenAstexViewer
146 - 152 5UN8 E 146 - 152 Jmol OpenAstexViewer
146 - 153 5UN8 F 146 - 153 Jmol OpenAstexViewer
H 146 - 153 Jmol OpenAstexViewer
146 - 154 5UN8 G 146 - 154 Jmol OpenAstexViewer
252 - 258 4RP6 Z 1 - 7 Jmol OpenAstexViewer
253 - 258 4RP7 Z 1 - 6 Jmol OpenAstexViewer
99 - 287 1YCS A 99 - 287 Jmol OpenAstexViewer
3D08 A 99 - 287 Jmol OpenAstexViewer
99 - 288 2AHI C 99 - 288 Jmol OpenAstexViewer
2J21 A 99 - 288 Jmol OpenAstexViewer
2YBG A 99 - 288 Jmol OpenAstexViewer
B 99 - 288 Jmol OpenAstexViewer
3D05 A 99 - 288 Jmol OpenAstexViewer
3D06 A 99 - 288 Jmol OpenAstexViewer
3D07 A 99 - 288 Jmol OpenAstexViewer
3D0A C 99 - 288 Jmol OpenAstexViewer
D 99 - 288 Jmol OpenAstexViewer
4IBQ A 99 - 288 Jmol OpenAstexViewer
B 99 - 288 Jmol OpenAstexViewer
C 99 - 288 Jmol OpenAstexViewer
D 99 - 288 Jmol OpenAstexViewer
4IBS A 99 - 288 Jmol OpenAstexViewer
4IBZ A 99 - 288 Jmol OpenAstexViewer
B 99 - 288 Jmol OpenAstexViewer
D 99 - 288 Jmol OpenAstexViewer
4MZI A 99 - 288 Jmol OpenAstexViewer
99 - 289 1GZH A 99 - 289 Jmol OpenAstexViewer
C 99 - 289 Jmol OpenAstexViewer
1KZY A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
1TSR A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
C 99 - 289 Jmol OpenAstexViewer
1TUP A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
C 99 - 289 Jmol OpenAstexViewer
1UOL A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
2AC0 A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
C 99 - 289 Jmol OpenAstexViewer
D 99 - 289 Jmol OpenAstexViewer
2ADY A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
2AHI A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
D 99 - 289 Jmol OpenAstexViewer
2ATA A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
C 99 - 289 Jmol OpenAstexViewer
D 99 - 289 Jmol OpenAstexViewer
2BIM A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
2BIN A 99 - 289 Jmol OpenAstexViewer
2BIO A 99 - 289 Jmol OpenAstexViewer
2BIP A 99 - 289 Jmol OpenAstexViewer
2BIQ A 99 - 289 Jmol OpenAstexViewer
2FEJ A 99 - 289 Jmol OpenAstexViewer
2H1L M 99 - 289 Jmol OpenAstexViewer
N 99 - 289 Jmol OpenAstexViewer
O 99 - 289 Jmol OpenAstexViewer
P 99 - 289 Jmol OpenAstexViewer
Q 99 - 289 Jmol OpenAstexViewer
R 99 - 289 Jmol OpenAstexViewer
S 99 - 289 Jmol OpenAstexViewer
T 99 - 289 Jmol OpenAstexViewer
U 99 - 289 Jmol OpenAstexViewer
V 99 - 289 Jmol OpenAstexViewer
W 99 - 289 Jmol OpenAstexViewer
X 99 - 289 Jmol OpenAstexViewer
2J1W A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
2J1X A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
2J1Y A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
C 99 - 289 Jmol OpenAstexViewer
D 99 - 289 Jmol OpenAstexViewer
2J1Z A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
2J20 A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
2J21 B 99 - 289 Jmol OpenAstexViewer
2MEJ B 99 - 289 Jmol OpenAstexViewer
2OCJ A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
C 99 - 289 Jmol OpenAstexViewer
D 99 - 289 Jmol OpenAstexViewer
2PCX A 99 - 289 Jmol OpenAstexViewer
2VUK A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
2WGX A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
2X0U A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
2X0V A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
2X0W A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
2XWR A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
2YBG C 99 - 289 Jmol OpenAstexViewer
D 99 - 289 Jmol OpenAstexViewer
3D07 B 99 - 289 Jmol OpenAstexViewer
3D09 A 99 - 289 Jmol OpenAstexViewer
3D0A A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
3IGK A 99 - 289 Jmol OpenAstexViewer
3IGL A 99 - 289 Jmol OpenAstexViewer
3KMD A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
C 99 - 289 Jmol OpenAstexViewer
D 99 - 289 Jmol OpenAstexViewer
3KZ8 A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
3Q01 A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
3Q05 A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
C 99 - 289 Jmol OpenAstexViewer
D 99 - 289 Jmol OpenAstexViewer
3Q06 A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
C 99 - 289 Jmol OpenAstexViewer
D 99 - 289 Jmol OpenAstexViewer
3TS8 A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
C 99 - 289 Jmol OpenAstexViewer
D 99 - 289 Jmol OpenAstexViewer
3ZME A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
4AGL A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
4AGM A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
4AGN A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
4AGO A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
4AGP A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
4AGQ A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
4HJE A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
C 99 - 289 Jmol OpenAstexViewer
D 99 - 289 Jmol OpenAstexViewer
4IBS B 99 - 289 Jmol OpenAstexViewer
C 99 - 289 Jmol OpenAstexViewer
D 99 - 289 Jmol OpenAstexViewer
4IBT A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
C 99 - 289 Jmol OpenAstexViewer
D 99 - 289 Jmol OpenAstexViewer
4IBU A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
C 99 - 289 Jmol OpenAstexViewer
D 99 - 289 Jmol OpenAstexViewer
4IBV A 99 - 289 Jmol OpenAstexViewer
4IBW A 99 - 289 Jmol OpenAstexViewer
4IBY A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
4IBZ C 99 - 289 Jmol OpenAstexViewer
4IJT A 99 - 289 Jmol OpenAstexViewer
4KVP A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
C 99 - 289 Jmol OpenAstexViewer
D 99 - 289 Jmol OpenAstexViewer
4LO9 A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
C 99 - 289 Jmol OpenAstexViewer
D 99 - 289 Jmol OpenAstexViewer
4LOE A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
C 99 - 289 Jmol OpenAstexViewer
D 99 - 289 Jmol OpenAstexViewer
4LOF A 99 - 289 Jmol OpenAstexViewer
4MZR A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
C 99 - 289 Jmol OpenAstexViewer
D 99 - 289 Jmol OpenAstexViewer
4QO1 B 99 - 289 Jmol OpenAstexViewer
4XR8 C 99 - 289 Jmol OpenAstexViewer
D 99 - 289 Jmol OpenAstexViewer
5A7B A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
5AB9 A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
5ABA A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
5AOI A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
5AOJ A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
5AOK A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
5AOL A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
5AOM A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
5BUA A 99 - 289 Jmol OpenAstexViewer
5ECG A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
5G4M A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
5G4N A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
5G4O A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
5LAP A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
5LGY A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
C 99 - 289 Jmol OpenAstexViewer
D 99 - 289 Jmol OpenAstexViewer
5O1A A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
5O1B A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
5O1C A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
5O1D A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
5O1E A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
5O1F A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
5O1G A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
5O1H A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
5O1I A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
6FF9 A 99 - 289 Jmol OpenAstexViewer
B 99 - 289 Jmol OpenAstexViewer
C 99 - 289 Jmol OpenAstexViewer
D 99 - 289 Jmol OpenAstexViewer
P53_TAD 13 - 30 2L14 B 13 - 30 Jmol OpenAstexViewer
14 - 30 2LY4 B 14 - 30 Jmol OpenAstexViewer
15 - 29 2MWY B 115 - 129 Jmol OpenAstexViewer
16 - 27 3DAB F 16 - 27 Jmol OpenAstexViewer
17 - 27 1YCQ B 17 - 27 Jmol OpenAstexViewer
2Z5S P 17 - 27 Jmol OpenAstexViewer
Q 17 - 27 Jmol OpenAstexViewer
2Z5T P 17 - 27 Jmol OpenAstexViewer
Q 17 - 27 Jmol OpenAstexViewer
R 17 - 27 Jmol OpenAstexViewer
3DAB D 17 - 27 Jmol OpenAstexViewer
4HFZ B 17 - 27 Jmol OpenAstexViewer
D 17 - 27 Jmol OpenAstexViewer
17 - 28 3DAB B 17 - 28 Jmol OpenAstexViewer
3DAC P 17 - 28 Jmol OpenAstexViewer
17 - 29 1YCR B 17 - 29 Jmol OpenAstexViewer
3DAC B 17 - 29 Jmol OpenAstexViewer
18 - 27 2Z5S R 18 - 27 Jmol OpenAstexViewer
18 - 28 3DAB H 18 - 28 Jmol OpenAstexViewer
6 - 30 2K8F B 6 - 30 Jmol OpenAstexViewer
5HOU A 1006 - 1030 Jmol OpenAstexViewer
5HPD A 3006 - 3030 Jmol OpenAstexViewer
P53_tetramer 319 - 358 1OLG A 319 - 358 Jmol OpenAstexViewer
B 319 - 358 Jmol OpenAstexViewer
C 319 - 358 Jmol OpenAstexViewer
D 319 - 358 Jmol OpenAstexViewer
1OLH A 319 - 358 Jmol OpenAstexViewer
B 319 - 358 Jmol OpenAstexViewer
C 319 - 358 Jmol OpenAstexViewer
D 319 - 358 Jmol OpenAstexViewer
1SAE A 319 - 358 Jmol OpenAstexViewer
B 319 - 358 Jmol OpenAstexViewer
C 319 - 358 Jmol OpenAstexViewer
D 319 - 358 Jmol OpenAstexViewer
1SAF A 319 - 358 Jmol OpenAstexViewer
B 319 - 358 Jmol OpenAstexViewer
C 319 - 358 Jmol OpenAstexViewer
D 319 - 358 Jmol OpenAstexViewer
1SAK A 319 - 358 Jmol OpenAstexViewer
B 319 - 358 Jmol OpenAstexViewer
C 319 - 358 Jmol OpenAstexViewer
D 319 - 358 Jmol OpenAstexViewer
1SAL A 319 - 358 Jmol OpenAstexViewer
B 319 - 358 Jmol OpenAstexViewer
C 319 - 358 Jmol OpenAstexViewer
D 319 - 358 Jmol OpenAstexViewer
3SAK A 1 - 40 Jmol OpenAstexViewer
B 1 - 40 Jmol OpenAstexViewer
C 1 - 40 Jmol OpenAstexViewer
D 1 - 40 Jmol OpenAstexViewer
321 - 354 3Q06 A 321 - 354 Jmol OpenAstexViewer
B 321 - 354 Jmol OpenAstexViewer
C 321 - 354 Jmol OpenAstexViewer
D 321 - 354 Jmol OpenAstexViewer
322 - 356 3Q01 A 322 - 356 Jmol OpenAstexViewer
B 322 - 356 Jmol OpenAstexViewer
3Q05 A 322 - 356 Jmol OpenAstexViewer
B 322 - 356 Jmol OpenAstexViewer
C 322 - 356 Jmol OpenAstexViewer
D 322 - 356 Jmol OpenAstexViewer
3TS8 A 322 - 356 Jmol OpenAstexViewer
B 322 - 356 Jmol OpenAstexViewer
C 322 - 356 Jmol OpenAstexViewer
D 322 - 356 Jmol OpenAstexViewer
4MZR A 322 - 356 Jmol OpenAstexViewer
B 322 - 356 Jmol OpenAstexViewer
C 322 - 356 Jmol OpenAstexViewer
D 322 - 356 Jmol OpenAstexViewer
324 - 357 1HS5 A 1 - 34 Jmol OpenAstexViewer
B 1 - 34 Jmol OpenAstexViewer
325 - 355 1PES A 325 - 355 Jmol OpenAstexViewer
B 325 - 355 Jmol OpenAstexViewer
C 325 - 355 Jmol OpenAstexViewer
D 325 - 355 Jmol OpenAstexViewer
1PET A 325 - 355 Jmol OpenAstexViewer
B 325 - 355 Jmol OpenAstexViewer
C 325 - 355 Jmol OpenAstexViewer
D 325 - 355 Jmol OpenAstexViewer
325 - 356 1C26 A 325 - 356 Jmol OpenAstexViewer
326 - 354 1A1U A 26 - 54 Jmol OpenAstexViewer
C 26 - 54 Jmol OpenAstexViewer
326 - 356 1AIE A 326 - 356 Jmol OpenAstexViewer
2J0Z A 326 - 356 Jmol OpenAstexViewer
B 326 - 356 Jmol OpenAstexViewer
C 326 - 356 Jmol OpenAstexViewer
D 326 - 356 Jmol OpenAstexViewer
2J10 A 326 - 356 Jmol OpenAstexViewer
B 326 - 356 Jmol OpenAstexViewer
C 326 - 356 Jmol OpenAstexViewer
D 326 - 356 Jmol OpenAstexViewer
2J11 A 326 - 356 Jmol OpenAstexViewer
B 326 - 356 Jmol OpenAstexViewer
C 326 - 356 Jmol OpenAstexViewer
D 326 - 356 Jmol OpenAstexViewer
TAD2 35 - 39 2K8F B 35 - 39 Jmol OpenAstexViewer
35 - 56 2B3G B 35 - 56 Jmol OpenAstexViewer
35 - 59 2L14 B 35 - 59 Jmol OpenAstexViewer
2LY4 B 35 - 59 Jmol OpenAstexViewer
2MZD B 1 - 25 Jmol OpenAstexViewer
5HOU A 1035 - 1059 Jmol OpenAstexViewer
5HPD A 3035 - 3059 Jmol OpenAstexViewer
37 - 59 5HP0 A 3037 - 3059 Jmol OpenAstexViewer
41 - 59 2RUK A 41 - 59 Jmol OpenAstexViewer
45 - 58 2GS0 B 45 - 58 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.