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48  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: AMYP_HUMAN (P04746)

Summary

This is the summary of UniProt entry AMYP_HUMAN (P04746).

Description: Pancreatic alpha-amylase
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 511 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 15
Pfam Alpha-amylase 77 347
disorder n/a 368 370
disorder n/a 374 375
disorder n/a 380 381
disorder n/a 383 385
Pfam Alpha-amylase_C 421 508

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P04746. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MKFFLLLFTI GFCWAQYSPN TQQGRTSIVH LFEWRWVDIA LECERYLAPK
50
51
GFGGVQVSPP NENVAIYNPF RPWWERYQPV SYKLCTRSGN EDEFRNMVTR
100
101
CNNVGVRIYV DAVINHMCGN AVSAGTSSTC GSYFNPGSRD FPAVPYSGWD
150
151
FNDGKCKTGS GDIENYNDAT QVRDCRLTGL LDLALEKDYV RSKIAEYMNH
200
201
LIDIGVAGFR LDASKHMWPG DIKAILDKLH NLNSNWFPAG SKPFIYQEVI
250
251
DLGGEPIKSS DYFGNGRVTE FKYGAKLGTV IRKWNGEKMS YLKNWGEGWG
300
301
FVPSDRALVF VDNHDNQRGH GAGGASILTF WDARLYKMAV GFMLAHPYGF
350
351
TRVMSSYRWP RQFQNGNDVN DWVGPPNNNG VIKEVTINPD TTCGNDWVCE
400
401
HRWRQIRNMV IFRNVVDGQP FTNWYDNGSN QVAFGRGNRG FIVFNNDDWS
450
451
FSLTLQTGLP AGTYCDVISG DKINGNCTGI KIYVSDDGKA HFSISNSAED
500
501
PFIAIHAESK L                                          
511
 

Show the unformatted sequence.

Checksums:
CRC64:A77B1A34EACB3C2A
MD5:d66e983815647cbdf36d9e6f2d6f2ccb

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Alpha-amylase 77 - 347 1B2Y A 62 - 332 Jmol OpenAstexViewer
1BSI A 62 - 332 Jmol OpenAstexViewer
1CPU A 62 - 332 Jmol OpenAstexViewer
1HNY A 62 - 332 Jmol OpenAstexViewer
1KB3 A 62 - 332 Jmol OpenAstexViewer
1KBB A 62 - 332 Jmol OpenAstexViewer
1KBK A 62 - 332 Jmol OpenAstexViewer
1KGU A 62 - 332 Jmol OpenAstexViewer
1KGW A 62 - 332 Jmol OpenAstexViewer
1KGX A 62 - 332 Jmol OpenAstexViewer
1U2Y A 62 - 332 Jmol OpenAstexViewer
1U30 A 62 - 332 Jmol OpenAstexViewer
1U33 A 62 - 332 Jmol OpenAstexViewer
1XCW A 62 - 332 Jmol OpenAstexViewer
1XCX A 62 - 332 Jmol OpenAstexViewer
1XD0 A 62 - 332 Jmol OpenAstexViewer
1XD1 A 62 - 332 Jmol OpenAstexViewer
1XGZ A 62 - 332 Jmol OpenAstexViewer
1XH0 A 62 - 332 Jmol OpenAstexViewer
1XH1 A 62 - 332 Jmol OpenAstexViewer
1XH2 A 62 - 332 Jmol OpenAstexViewer
2CPU A 62 - 332 Jmol OpenAstexViewer
2QMK A 62 - 332 Jmol OpenAstexViewer
2QV4 A 62 - 332 Jmol OpenAstexViewer
3BAI A 62 - 332 Jmol OpenAstexViewer
3BAJ A 62 - 332 Jmol OpenAstexViewer
3BAK A 62 - 332 Jmol OpenAstexViewer
3BAW A 62 - 332 Jmol OpenAstexViewer
3BAX A 62 - 332 Jmol OpenAstexViewer
3BAY A 62 - 332 Jmol OpenAstexViewer
3CPU A 62 - 332 Jmol OpenAstexViewer
3IJ7 A 62 - 332 Jmol OpenAstexViewer
3IJ8 A 62 - 332 Jmol OpenAstexViewer
3IJ9 A 62 - 332 Jmol OpenAstexViewer
3OLD A 62 - 332 Jmol OpenAstexViewer
3OLE A 62 - 332 Jmol OpenAstexViewer
3OLG A 62 - 332 Jmol OpenAstexViewer
3OLI A 62 - 332 Jmol OpenAstexViewer
4GQQ A 62 - 332 Jmol OpenAstexViewer
4GQR A 62 - 332 Jmol OpenAstexViewer
4W93 A 62 - 332 Jmol OpenAstexViewer
4X9Y A 62 - 332 Jmol OpenAstexViewer
5E0F A 62 - 332 Jmol OpenAstexViewer
5EMY A 62 - 332 Jmol OpenAstexViewer
5KEZ A 62 - 332 Jmol OpenAstexViewer
5TD4 A 62 - 332 Jmol OpenAstexViewer
5U3A A 62 - 332 Jmol OpenAstexViewer
5VA9 A 62 - 332 Jmol OpenAstexViewer
B 62 - 332 Jmol OpenAstexViewer
Alpha-amylase_C 421 - 508 1B2Y A 406 - 493 Jmol OpenAstexViewer
1BSI A 406 - 493 Jmol OpenAstexViewer
1CPU A 406 - 493 Jmol OpenAstexViewer
1HNY A 406 - 493 Jmol OpenAstexViewer
1KB3 A 406 - 493 Jmol OpenAstexViewer
1KBB A 406 - 493 Jmol OpenAstexViewer
1KBK A 406 - 493 Jmol OpenAstexViewer
1KGU A 406 - 493 Jmol OpenAstexViewer
1KGW A 406 - 493 Jmol OpenAstexViewer
1KGX A 406 - 493 Jmol OpenAstexViewer
1U2Y A 406 - 493 Jmol OpenAstexViewer
1U30 A 406 - 493 Jmol OpenAstexViewer
1U33 A 406 - 493 Jmol OpenAstexViewer
1XCW A 406 - 493 Jmol OpenAstexViewer
1XCX A 406 - 493 Jmol OpenAstexViewer
1XD0 A 406 - 493 Jmol OpenAstexViewer
1XD1 A 406 - 493 Jmol OpenAstexViewer
1XGZ A 406 - 493 Jmol OpenAstexViewer
1XH0 A 406 - 493 Jmol OpenAstexViewer
1XH1 A 406 - 493 Jmol OpenAstexViewer
1XH2 A 406 - 493 Jmol OpenAstexViewer
2CPU A 406 - 493 Jmol OpenAstexViewer
2QMK A 406 - 493 Jmol OpenAstexViewer
2QV4 A 406 - 493 Jmol OpenAstexViewer
3BAI A 406 - 493 Jmol OpenAstexViewer
3BAJ A 406 - 493 Jmol OpenAstexViewer
3BAK A 406 - 493 Jmol OpenAstexViewer
3BAW A 406 - 493 Jmol OpenAstexViewer
3BAX A 406 - 493 Jmol OpenAstexViewer
3BAY A 406 - 493 Jmol OpenAstexViewer
3CPU A 406 - 493 Jmol OpenAstexViewer
3IJ7 A 406 - 493 Jmol OpenAstexViewer
3IJ8 A 406 - 493 Jmol OpenAstexViewer
3IJ9 A 406 - 493 Jmol OpenAstexViewer
3OLD A 406 - 493 Jmol OpenAstexViewer
3OLE A 406 - 493 Jmol OpenAstexViewer
3OLG A 406 - 493 Jmol OpenAstexViewer
3OLI A 406 - 493 Jmol OpenAstexViewer
4GQQ A 406 - 493 Jmol OpenAstexViewer
4GQR A 406 - 493 Jmol OpenAstexViewer
4W93 A 406 - 493 Jmol OpenAstexViewer
4X9Y A 406 - 493 Jmol OpenAstexViewer
5E0F A 406 - 493 Jmol OpenAstexViewer
5EMY A 406 - 493 Jmol OpenAstexViewer
5KEZ A 406 - 493 Jmol OpenAstexViewer
5TD4 A 406 - 493 Jmol OpenAstexViewer
5U3A A 406 - 493 Jmol OpenAstexViewer
5VA9 A 406 - 493 Jmol OpenAstexViewer
B 406 - 493 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.