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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: CY24B_HUMAN (P04839)

Summary

This is the summary of UniProt entry CY24B_HUMAN (P04839).

Description: Cytochrome b-245 heavy chain EC=1.-.-.-
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 570 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
transmembrane n/a 12 33
low_complexity n/a 44 59
transmembrane n/a 45 69
Pfam Ferric_reduct 54 220
transmembrane n/a 103 121
transmembrane n/a 167 192
low_complexity n/a 176 196
transmembrane n/a 204 221
Pfam FAD_binding_8 292 395
Pfam NAD_binding_6 401 551
disorder n/a 547 551

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P04839. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGNWAVNEGL SIFVILVWLG LNVFLFVWYY RVYDIPPKFF YTRKLLGSAL
50
51
ALARAPAACL NFNCMLILLP VCRNLLSFLR GSSACCSTRV RRQLDRNLTF
100
101
HKMVAWMIAL HSAIHTIAHL FNVEWCVNAR VNNSDPYSVA LSELGDRQNE
150
151
SYLNFARKRI KNPEGGLYLA VTLLAGITGV VITLCLILII TSSTKTIRRS
200
201
YFEVFWYTHH LFVIFFIGLA IHGAERIVRG QTAESLAVHN ITVCEQKISE
250
251
WGKIKECPIP QFAGNPPMTW KWIVGPMFLY LCERLVRFWR SQQKVVITKV
300
301
VTHPFKTIEL QMKKKGFKME VGQYIFVKCP KVSKLEWHPF TLTSAPEEDF
350
351
FSIHIRIVGD WTEGLFNACG CDKQEFQDAW KLPKIAVDGP FGTASEDVFS
400
401
YEVVMLVGAG IGVTPFASIL KSVWYKYCNN ATNLKLKKIY FYWLCRDTHA
450
451
FEWFADLLQL LESQMQERNN AGFLSYNIYL TGWDESQANH FAVHHDEEKD
500
501
VITGLKQKTL YGRPNWDNEF KTIASQHPNT RIGVFLCGPE ALAETLSKQS
550
551
ISNSESGPRG VHFIFNKENF                                 
570
 

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Checksums:
CRC64:7E84051BD4000CE3
MD5:d036cb5f9e69aae333fda62ce035a092

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
FAD_binding_8 385 - 395 3A1F A 1 - 11 Jmol OpenAstexViewer
NAD_binding_6 401 - 551 3A1F A 17 - 167 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.