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154  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: A4_HUMAN (P05067)

Summary

This is the summary of UniProt entry A4_HUMAN (P05067).

Description: Amyloid-beta precursor protein {ECO:0000305}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 770 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
sig_p n/a 1 17
low_complexity n/a 2 18
Pfam APP_N 31 131
disorder n/a 49 50
Pfam APP_Cu_bd 132 188
low_complexity n/a 190 208
disorder n/a 195 216
disorder n/a 219 295
low_complexity n/a 222 267
coiled_coil n/a 228 248
low_complexity n/a 263 290
Pfam Kunitz_BPTI 290 342
disorder n/a 349 430
Pfam APP_E2 366 548
coiled_coil n/a 399 419
coiled_coil n/a 425 459
disorder n/a 434 459
disorder n/a 494 495
disorder n/a 509 514
coiled_coil n/a 555 575
disorder n/a 564 565
disorder n/a 591 594
disorder n/a 599 601
disorder n/a 624 659
disorder n/a 661 663
Pfam Beta-APP 675 713
transmembrane n/a 701 723
low_complexity n/a 706 723
Pfam APP_amyloid 716 766
disorder n/a 747 753

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P05067. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MLPGLALLLL AAWTARALEV PTDGNAGLLA EPQIAMFCGR LNMHMNVQNG
50
51
KWDSDPSGTK TCIDTKEGIL QYCQEVYPEL QITNVVEANQ PVTIQNWCKR
100
101
GRKQCKTHPH FVIPYRCLVG EFVSDALLVP DKCKFLHQER MDVCETHLHW
150
151
HTVAKETCSE KSTNLHDYGM LLPCGIDKFR GVEFVCCPLA EESDNVDSAD
200
201
AEEDDSDVWW GGADTDYADG SEDKVVEVAE EEEVAEVEEE EADDDEDDED
250
251
GDEVEEEAEE PYEEATERTT SIATTTTTTT ESVEEVVREV CSEQAETGPC
300
301
RAMISRWYFD VTEGKCAPFF YGGCGGNRNN FDTEEYCMAV CGSAMSQSLL
350
351
KTTQEPLARD PVKLPTTAAS TPDAVDKYLE TPGDENEHAH FQKAKERLEA
400
401
KHRERMSQVM REWEEAERQA KNLPKADKKA VIQHFQEKVE SLEQEAANER
450
451
QQLVETHMAR VEAMLNDRRR LALENYITAL QAVPPRPRHV FNMLKKYVRA
500
501
EQKDRQHTLK HFEHVRMVDP KKAAQIRSQV MTHLRVIYER MNQSLSLLYN
550
551
VPAVAEEIQD EVDELLQKEQ NYSDDVLANM ISEPRISYGN DALMPSLTET
600
601
KTTVELLPVN GEFSLDDLQP WHSFGADSVP ANTENEVEPV DARPAADRGL
650
651
TTRPGSGLTN IKTEEISEVK MDAEFRHDSG YEVHHQKLVF FAEDVGSNKG
700
701
AIIGLMVGGV VIATVIVITL VMLKKKQYTS IHHGVVEVDA AVTPEERHLS
750
751
KMQQNGYENP TYKFFEQMQN                                 
770
 

Show the unformatted sequence.

Checksums:
CRC64:A12EE761403740F5
MD5:7dd43312cd29a262acdc0517230bc5ca

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
APP_amyloid 716 - 726 2LLM A 33 - 43 Show 3D Structure View in InterPro
2LOH A 33 - 43 Show 3D Structure View in InterPro
B 33 - 43 Show 3D Structure View in InterPro
2LZ3 A 22 - 32 Show 3D Structure View in InterPro
B 22 - 32 Show 3D Structure View in InterPro
2LZ4 A 22 - 32 Show 3D Structure View in InterPro
B 22 - 32 Show 3D Structure View in InterPro
6IYC E 29 - 39 Show 3D Structure View in InterPro
6YHF A 45 - 55 Show 3D Structure View in InterPro
6YHI A 45 - 55 Show 3D Structure View in InterPro
6YHO A 45 - 55 Show 3D Structure View in InterPro
6YHP A 45 - 55 Show 3D Structure View in InterPro
6YHX A 45 - 55 Show 3D Structure View in InterPro
716 - 728 2LP1 A 716 - 728 Show 3D Structure View in InterPro
741 - 766 3DXC B 666 - 691 Show 3D Structure View in InterPro
742 - 766 3DXC D 667 - 691 Show 3D Structure View in InterPro
3DXD B 667 - 691 Show 3D Structure View in InterPro
D 667 - 691 Show 3D Structure View in InterPro
3DXE B 667 - 691 Show 3D Structure View in InterPro
D 667 - 691 Show 3D Structure View in InterPro
754 - 765 1X11 C 1 - 12 Show 3D Structure View in InterPro
754 - 766 1X11 D 1 - 13 Show 3D Structure View in InterPro
3SV1 D 754 - 766 Show 3D Structure View in InterPro
755 - 765 3SV1 E 755 - 765 Show 3D Structure View in InterPro
755 - 766 6ITU B 2 - 13 Show 3D Structure View in InterPro
756 - 758 3SV1 F 756 - 758 Show 3D Structure View in InterPro
756 - 762 3MXC L 681 - 687 Show 3D Structure View in InterPro
3MXY L 681 - 687 Show 3D Structure View in InterPro
761 - 766 3L81 B 686 - 691 Show 3D Structure View in InterPro
4MDR B 686 - 691 Show 3D Structure View in InterPro
APP_Cu_bd 132 - 188 1OWT A 132 - 188 Show 3D Structure View in InterPro
2FKL A 132 - 188 Show 3D Structure View in InterPro
B 132 - 188 Show 3D Structure View in InterPro
3KTM A 132 - 188 Show 3D Structure View in InterPro
B 132 - 188 Show 3D Structure View in InterPro
C 132 - 188 Show 3D Structure View in InterPro
D 132 - 188 Show 3D Structure View in InterPro
E 132 - 188 Show 3D Structure View in InterPro
F 132 - 188 Show 3D Structure View in InterPro
G 132 - 188 Show 3D Structure View in InterPro
H 132 - 188 Show 3D Structure View in InterPro
4PWQ A 132 - 188 Show 3D Structure View in InterPro
B 132 - 188 Show 3D Structure View in InterPro
133 - 188 2FJZ A 133 - 188 Show 3D Structure View in InterPro
2FK1 A 133 - 188 Show 3D Structure View in InterPro
2FK2 A 133 - 188 Show 3D Structure View in InterPro
2FK3 A 133 - 188 Show 3D Structure View in InterPro
B 133 - 188 Show 3D Structure View in InterPro
C 133 - 188 Show 3D Structure View in InterPro
D 133 - 188 Show 3D Structure View in InterPro
E 133 - 188 Show 3D Structure View in InterPro
F 133 - 188 Show 3D Structure View in InterPro
G 133 - 188 Show 3D Structure View in InterPro
H 133 - 188 Show 3D Structure View in InterPro
2FMA A 133 - 188 Show 3D Structure View in InterPro
APP_E2 371 - 548 3NYL A 352 - 529 Show 3D Structure View in InterPro
379 - 548 3NYJ A 360 - 529 Show 3D Structure View in InterPro
384 - 548 3UMK A 309 - 473 Show 3D Structure View in InterPro
385 - 548 3UMI A 310 - 473 Show 3D Structure View in InterPro
5BUO A 310 - 473 Show 3D Structure View in InterPro
388 - 548 3UMH A 313 - 473 Show 3D Structure View in InterPro
460 - 548 1TKN A 460 - 548 Show 3D Structure View in InterPro
APP_N 124 - 131 1OWT A 124 - 131 Show 3D Structure View in InterPro
126 - 131 2FKL A 126 - 131 Show 3D Structure View in InterPro
B 126 - 131 Show 3D Structure View in InterPro
31 - 123 1MWP A 31 - 123 Show 3D Structure View in InterPro
4JFN A 31 - 123 Show 3D Structure View in InterPro
31 - 126 4PQD A 31 - 126 Show 3D Structure View in InterPro
31 - 131 3KTM A 31 - 131 Show 3D Structure View in InterPro
B 31 - 131 Show 3D Structure View in InterPro
C 31 - 131 Show 3D Structure View in InterPro
D 31 - 131 Show 3D Structure View in InterPro
E 31 - 131 Show 3D Structure View in InterPro
F 31 - 131 Show 3D Structure View in InterPro
G 31 - 131 Show 3D Structure View in InterPro
H 31 - 131 Show 3D Structure View in InterPro
4PWQ A 31 - 131 Show 3D Structure View in InterPro
B 31 - 131 Show 3D Structure View in InterPro
Beta-APP 675 - 676 4ONG P 4 - 5 Show 3D Structure View in InterPro
675 - 677 3IFP S 4 - 6 Show 3D Structure View in InterPro
4HIX A 4 - 6 Show 3D Structure View in InterPro
4OJF A 4 - 6 Show 3D Structure View in InterPro
4ONF P 4 - 6 Show 3D Structure View in InterPro
675 - 678 3IFL P 4 - 7 Show 3D Structure View in InterPro
3IFN P 4 - 7 Show 3D Structure View in InterPro
3IFO P 4 - 7 Show 3D Structure View in InterPro
Q 4 - 7 Show 3D Structure View in InterPro
3IFP P 4 - 7 Show 3D Structure View in InterPro
Q 4 - 7 Show 3D Structure View in InterPro
R 4 - 7 Show 3D Structure View in InterPro
6CO3 Q 4 - 7 Show 3D Structure View in InterPro
675 - 679 2IPU P 4 - 8 Show 3D Structure View in InterPro
Q 4 - 8 Show 3D Structure View in InterPro
2R0W Q 4 - 8 Show 3D Structure View in InterPro
3BAE A 4 - 8 Show 3D Structure View in InterPro
3BKJ A 4 - 8 Show 3D Structure View in InterPro
3JQ5 B 4 - 8 Show 3D Structure View in InterPro
5MY4 C 2 - 6 Show 3D Structure View in InterPro
675 - 681 5CSZ E 4 - 10 Show 3D Structure View in InterPro
5LFY A 4 - 10 Show 3D Structure View in InterPro
B 4 - 10 Show 3D Structure View in InterPro
675 - 682 5CSZ D 4 - 11 Show 3D Structure View in InterPro
675 - 683 5MYO E 2 - 10 Show 3D Structure View in InterPro
675 - 685 5MYX E 2 - 12 Show 3D Structure View in InterPro
675 - 687 1ZE7 A 4 - 16 Show 3D Structure View in InterPro
1ZE9 A 4 - 16 Show 3D Structure View in InterPro
2BP4 A 4 - 16 Show 3D Structure View in InterPro
2MGT A 4 - 16 Show 3D Structure View in InterPro
B 4 - 16 Show 3D Structure View in InterPro
5W3P P 4 - 16 Show 3D Structure View in InterPro
675 - 689 5MYX F 2 - 16 Show 3D Structure View in InterPro
675 - 691 4M1C G 4 - 20 Show 3D Structure View in InterPro
675 - 699 1AMB A 4 - 28 Show 3D Structure View in InterPro
1AMC A 4 - 28 Show 3D Structure View in InterPro
1BJB A 4 - 28 Show 3D Structure View in InterPro
1BJC A 4 - 28 Show 3D Structure View in InterPro
675 - 711 1AML A 4 - 40 Show 3D Structure View in InterPro
1BA4 A 4 - 40 Show 3D Structure View in InterPro
1BA6 A 4 - 40 Show 3D Structure View in InterPro
2LFM A 4 - 40 Show 3D Structure View in InterPro
2M4J A 4 - 40 Show 3D Structure View in InterPro
B 4 - 40 Show 3D Structure View in InterPro
C 4 - 40 Show 3D Structure View in InterPro
D 4 - 40 Show 3D Structure View in InterPro
E 4 - 40 Show 3D Structure View in InterPro
F 4 - 40 Show 3D Structure View in InterPro
G 4 - 40 Show 3D Structure View in InterPro
H 4 - 40 Show 3D Structure View in InterPro
I 4 - 40 Show 3D Structure View in InterPro
2M9R A 4 - 40 Show 3D Structure View in InterPro
2M9S A 4 - 40 Show 3D Structure View in InterPro
2MVX A 4 - 40 Show 3D Structure View in InterPro
B 4 - 40 Show 3D Structure View in InterPro
C 4 - 40 Show 3D Structure View in InterPro
D 4 - 40 Show 3D Structure View in InterPro
E 4 - 40 Show 3D Structure View in InterPro
F 4 - 40 Show 3D Structure View in InterPro
G 4 - 40 Show 3D Structure View in InterPro
H 4 - 40 Show 3D Structure View in InterPro
I 4 - 40 Show 3D Structure View in InterPro
J 4 - 40 Show 3D Structure View in InterPro
6OC9 A 4 - 40 Show 3D Structure View in InterPro
B 4 - 40 Show 3D Structure View in InterPro
C 4 - 40 Show 3D Structure View in InterPro
D 4 - 40 Show 3D Structure View in InterPro
E 4 - 40 Show 3D Structure View in InterPro
F 4 - 40 Show 3D Structure View in InterPro
G 4 - 40 Show 3D Structure View in InterPro
H 4 - 40 Show 3D Structure View in InterPro
I 4 - 40 Show 3D Structure View in InterPro
J 4 - 40 Show 3D Structure View in InterPro
6SHS A 4 - 40 Show 3D Structure View in InterPro
B 4 - 40 Show 3D Structure View in InterPro
C 4 - 40 Show 3D Structure View in InterPro
D 4 - 40 Show 3D Structure View in InterPro
E 4 - 40 Show 3D Structure View in InterPro
F 4 - 40 Show 3D Structure View in InterPro
G 4 - 40 Show 3D Structure View in InterPro
H 4 - 40 Show 3D Structure View in InterPro
I 4 - 40 Show 3D Structure View in InterPro
J 4 - 40 Show 3D Structure View in InterPro
K 4 - 40 Show 3D Structure View in InterPro
L 4 - 40 Show 3D Structure View in InterPro
675 - 713 1IYT A 4 - 42 Show 3D Structure View in InterPro
1Z0Q A 4 - 42 Show 3D Structure View in InterPro
2NAO A 4 - 42 Show 3D Structure View in InterPro
B 4 - 42 Show 3D Structure View in InterPro
C 4 - 42 Show 3D Structure View in InterPro
D 4 - 42 Show 3D Structure View in InterPro
E 4 - 42 Show 3D Structure View in InterPro
F 4 - 42 Show 3D Structure View in InterPro
5OQV A 4 - 42 Show 3D Structure View in InterPro
B 4 - 42 Show 3D Structure View in InterPro
C 4 - 42 Show 3D Structure View in InterPro
D 4 - 42 Show 3D Structure View in InterPro
E 4 - 42 Show 3D Structure View in InterPro
F 4 - 42 Show 3D Structure View in InterPro
G 4 - 42 Show 3D Structure View in InterPro
H 4 - 42 Show 3D Structure View in InterPro
I 4 - 42 Show 3D Structure View in InterPro
6RHY A 4 - 42 Show 3D Structure View in InterPro
B 4 - 42 Show 3D Structure View in InterPro
C 4 - 42 Show 3D Structure View in InterPro
D 4 - 42 Show 3D Structure View in InterPro
6SZF A 4 - 42 Show 3D Structure View in InterPro
678 - 680 5AM8 P 7 - 9 Show 3D Structure View in InterPro
Q 7 - 9 Show 3D Structure View in InterPro
R 7 - 9 Show 3D Structure View in InterPro
S 7 - 9 Show 3D Structure View in InterPro
680 - 711 2LMN A 9 - 40 Show 3D Structure View in InterPro
B 9 - 40 Show 3D Structure View in InterPro
C 9 - 40 Show 3D Structure View in InterPro
D 9 - 40 Show 3D Structure View in InterPro
E 9 - 40 Show 3D Structure View in InterPro
F 9 - 40 Show 3D Structure View in InterPro
G 9 - 40 Show 3D Structure View in InterPro
H 9 - 40 Show 3D Structure View in InterPro
I 9 - 40 Show 3D Structure View in InterPro
J 9 - 40 Show 3D Structure View in InterPro
K 9 - 40 Show 3D Structure View in InterPro
L 9 - 40 Show 3D Structure View in InterPro
2LMO A 9 - 40 Show 3D Structure View in InterPro
B 9 - 40 Show 3D Structure View in InterPro
C 9 - 40 Show 3D Structure View in InterPro
D 9 - 40 Show 3D Structure View in InterPro
E 9 - 40 Show 3D Structure View in InterPro
F 9 - 40 Show 3D Structure View in InterPro
G 9 - 40 Show 3D Structure View in InterPro
H 9 - 40 Show 3D Structure View in InterPro
I 9 - 40 Show 3D Structure View in InterPro
J 9 - 40 Show 3D Structure View in InterPro
K 9 - 40 Show 3D Structure View in InterPro
L 9 - 40 Show 3D Structure View in InterPro
2LMP A 9 - 40 Show 3D Structure View in InterPro
B 9 - 40 Show 3D Structure View in InterPro
C 9 - 40 Show 3D Structure View in InterPro
D 9 - 40 Show 3D Structure View in InterPro
E 9 - 40 Show 3D Structure View in InterPro
F 9 - 40 Show 3D Structure View in InterPro
G 9 - 40 Show 3D Structure View in InterPro
H 9 - 40 Show 3D Structure View in InterPro
I 9 - 40 Show 3D Structure View in InterPro
J 9 - 40 Show 3D Structure View in InterPro
K 9 - 40 Show 3D Structure View in InterPro
L 9 - 40 Show 3D Structure View in InterPro
M 9 - 40 Show 3D Structure View in InterPro
N 9 - 40 Show 3D Structure View in InterPro
O 9 - 40 Show 3D Structure View in InterPro
P 9 - 40 Show 3D Structure View in InterPro
Q 9 - 40 Show 3D Structure View in InterPro
R 9 - 40 Show 3D Structure View in InterPro
2LMQ A 9 - 40 Show 3D Structure View in InterPro
B 9 - 40 Show 3D Structure View in InterPro
C 9 - 40 Show 3D Structure View in InterPro
D 9 - 40 Show 3D Structure View in InterPro
E 9 - 40 Show 3D Structure View in InterPro
F 9 - 40 Show 3D Structure View in InterPro
G 9 - 40 Show 3D Structure View in InterPro
H 9 - 40 Show 3D Structure View in InterPro
I 9 - 40 Show 3D Structure View in InterPro
J 9 - 40 Show 3D Structure View in InterPro
K 9 - 40 Show 3D Structure View in InterPro
L 9 - 40 Show 3D Structure View in InterPro
M 9 - 40 Show 3D Structure View in InterPro
N 9 - 40 Show 3D Structure View in InterPro
O 9 - 40 Show 3D Structure View in InterPro
P 9 - 40 Show 3D Structure View in InterPro
Q 9 - 40 Show 3D Structure View in InterPro
R 9 - 40 Show 3D Structure View in InterPro
681 - 706 1HZ3 A 1 - 26 Show 3D Structure View in InterPro
682 - 711 6TI5 A 11 - 40 Show 3D Structure View in InterPro
B 11 - 40 Show 3D Structure View in InterPro
C 11 - 40 Show 3D Structure View in InterPro
D 11 - 40 Show 3D Structure View in InterPro
E 11 - 40 Show 3D Structure View in InterPro
F 11 - 40 Show 3D Structure View in InterPro
G 11 - 40 Show 3D Structure View in InterPro
H 11 - 40 Show 3D Structure View in InterPro
I 11 - 40 Show 3D Structure View in InterPro
J 11 - 40 Show 3D Structure View in InterPro
K 11 - 40 Show 3D Structure View in InterPro
L 11 - 40 Show 3D Structure View in InterPro
M 11 - 40 Show 3D Structure View in InterPro
N 11 - 40 Show 3D Structure View in InterPro
O 11 - 40 Show 3D Structure View in InterPro
P 11 - 40 Show 3D Structure View in InterPro
6TI6 A 11 - 40 Show 3D Structure View in InterPro
C 11 - 40 Show 3D Structure View in InterPro
E 11 - 40 Show 3D Structure View in InterPro
G 11 - 40 Show 3D Structure View in InterPro
I 11 - 40 Show 3D Structure View in InterPro
K 11 - 40 Show 3D Structure View in InterPro
M 11 - 40 Show 3D Structure View in InterPro
O 11 - 40 Show 3D Structure View in InterPro
6TI7 A 11 - 40 Show 3D Structure View in InterPro
C 11 - 40 Show 3D Structure View in InterPro
E 11 - 40 Show 3D Structure View in InterPro
G 11 - 40 Show 3D Structure View in InterPro
J 11 - 40 Show 3D Structure View in InterPro
L 11 - 40 Show 3D Structure View in InterPro
N 11 - 40 Show 3D Structure View in InterPro
P 11 - 40 Show 3D Structure View in InterPro
682 - 713 2MXU A 11 - 42 Show 3D Structure View in InterPro
B 11 - 42 Show 3D Structure View in InterPro
C 11 - 42 Show 3D Structure View in InterPro
D 11 - 42 Show 3D Structure View in InterPro
E 11 - 42 Show 3D Structure View in InterPro
F 11 - 42 Show 3D Structure View in InterPro
G 11 - 42 Show 3D Structure View in InterPro
H 11 - 42 Show 3D Structure View in InterPro
I 11 - 42 Show 3D Structure View in InterPro
J 11 - 42 Show 3D Structure View in InterPro
K 11 - 42 Show 3D Structure View in InterPro
L 11 - 42 Show 3D Structure View in InterPro
5KK3 A 11 - 42 Show 3D Structure View in InterPro
B 11 - 42 Show 3D Structure View in InterPro
C 11 - 42 Show 3D Structure View in InterPro
D 11 - 42 Show 3D Structure View in InterPro
E 11 - 42 Show 3D Structure View in InterPro
F 11 - 42 Show 3D Structure View in InterPro
G 11 - 42 Show 3D Structure View in InterPro
H 11 - 42 Show 3D Structure View in InterPro
I 11 - 42 Show 3D Structure View in InterPro
J 11 - 42 Show 3D Structure View in InterPro
K 11 - 42 Show 3D Structure View in InterPro
L 11 - 42 Show 3D Structure View in InterPro
M 11 - 42 Show 3D Structure View in InterPro
N 11 - 42 Show 3D Structure View in InterPro
O 11 - 42 Show 3D Structure View in InterPro
P 11 - 42 Show 3D Structure View in InterPro
Q 11 - 42 Show 3D Structure View in InterPro
R 11 - 42 Show 3D Structure View in InterPro
6TI6 B 11 - 42 Show 3D Structure View in InterPro
D 11 - 42 Show 3D Structure View in InterPro
F 11 - 42 Show 3D Structure View in InterPro
H 11 - 42 Show 3D Structure View in InterPro
J 11 - 42 Show 3D Structure View in InterPro
L 11 - 42 Show 3D Structure View in InterPro
N 11 - 42 Show 3D Structure View in InterPro
P 11 - 42 Show 3D Structure View in InterPro
6TI7 B 11 - 42 Show 3D Structure View in InterPro
D 11 - 42 Show 3D Structure View in InterPro
F 11 - 42 Show 3D Structure View in InterPro
H 11 - 42 Show 3D Structure View in InterPro
I 11 - 42 Show 3D Structure View in InterPro
K 11 - 42 Show 3D Structure View in InterPro
M 11 - 42 Show 3D Structure View in InterPro
O 11 - 42 Show 3D Structure View in InterPro
683 - 713 2LP1 A 683 - 713 Show 3D Structure View in InterPro
684 - 695 5VZY A 13 - 24 Show 3D Structure View in InterPro
685 - 706 6WXM A 1 - 22 Show 3D Structure View in InterPro
B 1 - 22 Show 3D Structure View in InterPro
C 1 - 22 Show 3D Structure View in InterPro
D 1 - 22 Show 3D Structure View in InterPro
E 1 - 22 Show 3D Structure View in InterPro
F 1 - 22 Show 3D Structure View in InterPro
G 1 - 22 Show 3D Structure View in InterPro
H 1 - 22 Show 3D Structure View in InterPro
I 1 - 22 Show 3D Structure View in InterPro
J 1 - 22 Show 3D Structure View in InterPro
K 1 - 22 Show 3D Structure View in InterPro
686 - 694 4NGE B 15 - 23 Show 3D Structure View in InterPro
686 - 706 7JXN A 1 - 21 Show 3D Structure View in InterPro
B 1 - 21 Show 3D Structure View in InterPro
C 1 - 21 Show 3D Structure View in InterPro
D 1 - 21 Show 3D Structure View in InterPro
7JXO A 1 - 21 Show 3D Structure View in InterPro
B 1 - 21 Show 3D Structure View in InterPro
C 1 - 21 Show 3D Structure View in InterPro
686 - 711 2LNQ A 15 - 40 Show 3D Structure View in InterPro
B 15 - 40 Show 3D Structure View in InterPro
C 15 - 40 Show 3D Structure View in InterPro
D 15 - 40 Show 3D Structure View in InterPro
E 15 - 40 Show 3D Structure View in InterPro
F 15 - 40 Show 3D Structure View in InterPro
G 15 - 40 Show 3D Structure View in InterPro
H 15 - 40 Show 3D Structure View in InterPro
2MPZ a 15 - 40 Show 3D Structure View in InterPro
A 15 - 40 Show 3D Structure View in InterPro
B 15 - 40 Show 3D Structure View in InterPro
C 15 - 40 Show 3D Structure View in InterPro
D 15 - 40 Show 3D Structure View in InterPro
E 15 - 40 Show 3D Structure View in InterPro
F 15 - 40 Show 3D Structure View in InterPro
G 15 - 40 Show 3D Structure View in InterPro
H 15 - 40 Show 3D Structure View in InterPro
I 15 - 40 Show 3D Structure View in InterPro
J 15 - 40 Show 3D Structure View in InterPro
K 15 - 40 Show 3D Structure View in InterPro
L 15 - 40 Show 3D Structure View in InterPro
M 15 - 40 Show 3D Structure View in InterPro
N 15 - 40 Show 3D Structure View in InterPro
O 15 - 40 Show 3D Structure View in InterPro
P 15 - 40 Show 3D Structure View in InterPro
Q 15 - 40 Show 3D Structure View in InterPro
R 15 - 40 Show 3D Structure View in InterPro
S 15 - 40 Show 3D Structure View in InterPro
T 15 - 40 Show 3D Structure View in InterPro
U 15 - 40 Show 3D Structure View in InterPro
V 15 - 40 Show 3D Structure View in InterPro
W 15 - 40 Show 3D Structure View in InterPro
X 15 - 40 Show 3D Structure View in InterPro
Y 15 - 40 Show 3D Structure View in InterPro
Z 15 - 40 Show 3D Structure View in InterPro
686 - 713 2LLM A 3 - 30 Show 3D Structure View in InterPro
2LOH A 3 - 30 Show 3D Structure View in InterPro
B 3 - 30 Show 3D Structure View in InterPro
5AEF A 15 - 42 Show 3D Structure View in InterPro
B 15 - 42 Show 3D Structure View in InterPro
687 - 692 2Y29 A 2 - 7 Show 3D Structure View in InterPro
2Y2A A 2 - 7 Show 3D Structure View in InterPro
3JQL B 1 - 6 Show 3D Structure View in InterPro
3OVJ A 1 - 6 Show 3D Structure View in InterPro
B 1 - 6 Show 3D Structure View in InterPro
C 1 - 6 Show 3D Structure View in InterPro
D 1 - 6 Show 3D Structure View in InterPro
3OW9 A 1 - 6 Show 3D Structure View in InterPro
B 1 - 6 Show 3D Structure View in InterPro
687 - 693 2WK3 C 16 - 22 Show 3D Structure View in InterPro
D 16 - 22 Show 3D Structure View in InterPro
687 - 694 2G47 C 16 - 23 Show 3D Structure View in InterPro
D 16 - 23 Show 3D Structure View in InterPro
687 - 695 4XXD F 16 - 24 Show 3D Structure View in InterPro
687 - 697 4XXD C 16 - 26 Show 3D Structure View in InterPro
6O4J A 16 - 26 Show 3D Structure View in InterPro
B 16 - 26 Show 3D Structure View in InterPro
687 - 699 4MVI B 16 - 28 Show 3D Structure View in InterPro
687 - 711 2OTK C 16 - 40 Show 3D Structure View in InterPro
688 - 698 4MVL E 17 - 27 Show 3D Structure View in InterPro
F 17 - 27 Show 3D Structure View in InterPro
688 - 705 2MJ1 A 1 - 18 Show 3D Structure View in InterPro
688 - 707 5HOW A 2 - 21 Show 3D Structure View in InterPro
B 2 - 21 Show 3D Structure View in InterPro
C 2 - 21 Show 3D Structure View in InterPro
D 2 - 21 Show 3D Structure View in InterPro
E 2 - 21 Show 3D Structure View in InterPro
F 2 - 21 Show 3D Structure View in InterPro
5HOX A 2 - 21 Show 3D Structure View in InterPro
B 2 - 21 Show 3D Structure View in InterPro
C 2 - 21 Show 3D Structure View in InterPro
D 2 - 21 Show 3D Structure View in InterPro
E 2 - 21 Show 3D Structure View in InterPro
F 2 - 21 Show 3D Structure View in InterPro
5HOY A 2 - 21 Show 3D Structure View in InterPro
B 2 - 21 Show 3D Structure View in InterPro
C 2 - 21 Show 3D Structure View in InterPro
D 2 - 21 Show 3D Structure View in InterPro
E 2 - 21 Show 3D Structure View in InterPro
F 2 - 21 Show 3D Structure View in InterPro
688 - 713 2BEG A 17 - 42 Show 3D Structure View in InterPro
B 17 - 42 Show 3D Structure View in InterPro
C 17 - 42 Show 3D Structure View in InterPro
D 17 - 42 Show 3D Structure View in InterPro
E 17 - 42 Show 3D Structure View in InterPro
6IYC E 1 - 26 Show 3D Structure View in InterPro
689 - 693 4NGE E 18 - 22 Show 3D Structure View in InterPro
689 - 694 4MVK B 18 - 23 Show 3D Structure View in InterPro
689 - 697 4MVL G 18 - 26 Show 3D Structure View in InterPro
H 18 - 26 Show 3D Structure View in InterPro
689 - 712 3MOQ A 88 - 111 Show 3D Structure View in InterPro
B 88 - 111 Show 3D Structure View in InterPro
C 88 - 111 Show 3D Structure View in InterPro
D 88 - 111 Show 3D Structure View in InterPro
691 - 705 6NB9 A 20 - 34 Show 3D Structure View in InterPro
6OIZ A 20 - 34 Show 3D Structure View in InterPro
695 - 705 5VOS A 24 - 34 Show 3D Structure View in InterPro
696 - 706 1QCM A 1 - 11 Show 3D Structure View in InterPro
1QWP A 25 - 35 Show 3D Structure View in InterPro
1QXC A 25 - 35 Show 3D Structure View in InterPro
1QYT A 25 - 35 Show 3D Structure View in InterPro
697 - 713 6YHF A 26 - 42 Show 3D Structure View in InterPro
6YHI A 26 - 42 Show 3D Structure View in InterPro
6YHO A 26 - 42 Show 3D Structure View in InterPro
6YHP A 26 - 42 Show 3D Structure View in InterPro
6YHX A 26 - 42 Show 3D Structure View in InterPro
698 - 703 3Q2X A 1 - 6 Show 3D Structure View in InterPro
5TXD Z 1 - 6 Show 3D Structure View in InterPro
699 - 706 3JTI B 1 - 8 Show 3D Structure View in InterPro
699 - 713 2LZ3 A 5 - 19 Show 3D Structure View in InterPro
B 5 - 19 Show 3D Structure View in InterPro
2LZ4 A 5 - 19 Show 3D Structure View in InterPro
B 5 - 19 Show 3D Structure View in InterPro
700 - 704 5ONP B 29 - 33 Show 3D Structure View in InterPro
5ONQ B 29 - 33 Show 3D Structure View in InterPro
700 - 705 3PZZ A 1 - 6 Show 3D Structure View in InterPro
B 1 - 6 Show 3D Structure View in InterPro
701 - 706 2Y3J A 1 - 6 Show 3D Structure View in InterPro
B 1 - 6 Show 3D Structure View in InterPro
C 1 - 6 Show 3D Structure View in InterPro
D 1 - 6 Show 3D Structure View in InterPro
E 1 - 6 Show 3D Structure View in InterPro
F 1 - 6 Show 3D Structure View in InterPro
G 1 - 6 Show 3D Structure View in InterPro
H 1 - 6 Show 3D Structure View in InterPro
701 - 711 3U0T E 30 - 40 Show 3D Structure View in InterPro
F 30 - 40 Show 3D Structure View in InterPro
702 - 704 5ONR B 31 - 33 Show 3D Structure View in InterPro
706 - 713 2Y3K A 1 - 8 Show 3D Structure View in InterPro
B 1 - 8 Show 3D Structure View in InterPro
C 1 - 8 Show 3D Structure View in InterPro
D 1 - 8 Show 3D Structure View in InterPro
E 1 - 8 Show 3D Structure View in InterPro
F 1 - 8 Show 3D Structure View in InterPro
G 1 - 8 Show 3D Structure View in InterPro
H 1 - 8 Show 3D Structure View in InterPro
2Y3L A 1 - 8 Show 3D Structure View in InterPro
B 1 - 8 Show 3D Structure View in InterPro
C 1 - 8 Show 3D Structure View in InterPro
G 1 - 8 Show 3D Structure View in InterPro
707 - 713 3GCI P 1 - 7 Show 3D Structure View in InterPro
709 - 711 5LV0 C 4 - 6 Show 3D Structure View in InterPro
D 4 - 6 Show 3D Structure View in InterPro
712 - 713 5AMB P 41 - 42 Show 3D Structure View in InterPro
Q 41 - 42 Show 3D Structure View in InterPro
Kunitz_BPTI 290 - 301 5NX1 B 4 - 15 Show 3D Structure View in InterPro
5NX3 B 4 - 15 Show 3D Structure View in InterPro
290 - 341 3L33 E 4 - 55 Show 3D Structure View in InterPro
F 4 - 55 Show 3D Structure View in InterPro
G 4 - 55 Show 3D Structure View in InterPro
H 4 - 55 Show 3D Structure View in InterPro
5NX3 C 4 - 55 Show 3D Structure View in InterPro
290 - 342 1AAP A 4 - 56 Show 3D Structure View in InterPro
B 4 - 56 Show 3D Structure View in InterPro
1BRC I 4 - 56 Show 3D Structure View in InterPro
1CA0 D 4 - 56 Show 3D Structure View in InterPro
I 4 - 56 Show 3D Structure View in InterPro
1TAW B 4 - 56 Show 3D Structure View in InterPro
1ZJD B 4 - 56 Show 3D Structure View in InterPro
5NX1 C 4 - 56 Show 3D Structure View in InterPro
294 - 341 5C67 C 8 - 55 Show 3D Structure View in InterPro
294 - 342 5C67 E 8 - 56 Show 3D Structure View in InterPro
6GFI C 8 - 56 Show 3D Structure View in InterPro
E 8 - 56 Show 3D Structure View in InterPro
302 - 342 5NX1 D 16 - 56 Show 3D Structure View in InterPro
306 - 342 5NX3 D 20 - 56 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;