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75  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: KAPCA_MOUSE (P05132)

Summary

This is the summary of UniProt entry KAPCA_MOUSE (P05132).

Description: cAMP-dependent protein kinase catalytic subunit alpha EC=2.7.11.11
Source organism: Mus musculus (Mouse) (NCBI taxonomy ID 10090)
Length: 351 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 7
Pfam Pkinase 44 298

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P05132. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGNAAAAKKG SEQESVKEFL AKAKEDFLKK WETPSQNTAQ LDQFDRIKTL
50
51
GTGSFGRVML VKHKESGNHY AMKILDKQKV VKLKQIEHTL NEKRILQAVN
100
101
FPFLVKLEFS FKDNSNLYMV MEYVAGGEMF SHLRRIGRFS EPHARFYAAQ
150
151
IVLTFEYLHS LDLIYRDLKP ENLLIDQQGY IQVTDFGFAK RVKGRTWTLC
200
201
GTPEYLAPEI ILSKGYNKAV DWWALGVLIY EMAAGYPPFF ADQPIQIYEK
250
251
IVSGKVRFPS HFSSDLKDLL RNLLQVDLTK RFGNLKNGVN DIKNHKWFAT
300
301
TDWIAIYQRK VEAPFIPKFK GPGDTSNFDD YEEEEIRVSI NEKCGKEFTE
350
351
F                                                     
351
 

Show the unformatted sequence.

Checksums:
CRC64:02F85D66EB21A1FA
MD5:e94718b912416fd121140fa1cca31e0e

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Pkinase 44 - 298 1APM E 43 - 297 Show 3D Structure View in InterPro
1ATP E 43 - 297 Show 3D Structure View in InterPro
1BKX A 43 - 297 Show 3D Structure View in InterPro
1BX6 A 43 - 297 Show 3D Structure View in InterPro
1FMO E 43 - 297 Show 3D Structure View in InterPro
1J3H A 43 - 297 Show 3D Structure View in InterPro
B 43 - 297 Show 3D Structure View in InterPro
1JBP E 43 - 297 Show 3D Structure View in InterPro
1JLU E 43 - 297 Show 3D Structure View in InterPro
1L3R E 43 - 297 Show 3D Structure View in InterPro
1RDQ E 43 - 297 Show 3D Structure View in InterPro
1RE8 A 43 - 297 Show 3D Structure View in InterPro
1REJ A 43 - 297 Show 3D Structure View in InterPro
1REK A 43 - 297 Show 3D Structure View in InterPro
1SYK A 43 - 297 Show 3D Structure View in InterPro
B 43 - 297 Show 3D Structure View in InterPro
2CPK E 43 - 297 Show 3D Structure View in InterPro
2ERZ E 43 - 297 Show 3D Structure View in InterPro
2QCS A 43 - 297 Show 3D Structure View in InterPro
2QUR A 43 - 297 Show 3D Structure View in InterPro
2QVS E 43 - 297 Show 3D Structure View in InterPro
3FHI A 43 - 297 Show 3D Structure View in InterPro
3FJQ E 43 - 297 Show 3D Structure View in InterPro
3IDB A 43 - 297 Show 3D Structure View in InterPro
3IDC A 43 - 297 Show 3D Structure View in InterPro
3J4Q D 43 - 297 Show 3D Structure View in InterPro
E 43 - 297 Show 3D Structure View in InterPro
3J4R D 43 - 297 Show 3D Structure View in InterPro
E 43 - 297 Show 3D Structure View in InterPro
3O7L B 43 - 297 Show 3D Structure View in InterPro
D 43 - 297 Show 3D Structure View in InterPro
3OW3 A 43 - 297 Show 3D Structure View in InterPro
3PVB A 43 - 297 Show 3D Structure View in InterPro
3QAL E 43 - 297 Show 3D Structure View in InterPro
3QAM E 43 - 297 Show 3D Structure View in InterPro
3TNP C 43 - 297 Show 3D Structure View in InterPro
F 43 - 297 Show 3D Structure View in InterPro
3X2U A 43 - 297 Show 3D Structure View in InterPro
3X2V A 43 - 297 Show 3D Structure View in InterPro
3X2W A 43 - 297 Show 3D Structure View in InterPro
4DFX E 43 - 297 Show 3D Structure View in InterPro
4DFY A 43 - 297 Show 3D Structure View in InterPro
E 43 - 297 Show 3D Structure View in InterPro
4DFZ E 43 - 297 Show 3D Structure View in InterPro
4DG0 E 43 - 297 Show 3D Structure View in InterPro
4DG2 E 43 - 297 Show 3D Structure View in InterPro
4DG3 E 43 - 297 Show 3D Structure View in InterPro
4DH1 A 43 - 297 Show 3D Structure View in InterPro
4DH3 A 43 - 297 Show 3D Structure View in InterPro
4DH5 A 43 - 297 Show 3D Structure View in InterPro
4DH7 A 43 - 297 Show 3D Structure View in InterPro
4DH8 A 43 - 297 Show 3D Structure View in InterPro
4DIN A 43 - 297 Show 3D Structure View in InterPro
4HPT E 43 - 297 Show 3D Structure View in InterPro
4HPU E 43 - 297 Show 3D Structure View in InterPro
4IAC A 43 - 297 Show 3D Structure View in InterPro
4IAD A 43 - 297 Show 3D Structure View in InterPro
4IAF A 43 - 297 Show 3D Structure View in InterPro
4IAI A 43 - 297 Show 3D Structure View in InterPro
4IAK A 43 - 297 Show 3D Structure View in InterPro
4IAY A 43 - 297 Show 3D Structure View in InterPro
4IAZ A 43 - 297 Show 3D Structure View in InterPro
4IB0 A 43 - 297 Show 3D Structure View in InterPro
4IB1 A 43 - 297 Show 3D Structure View in InterPro
4IB3 A 43 - 297 Show 3D Structure View in InterPro
4NTS A 43 - 297 Show 3D Structure View in InterPro
B 43 - 297 Show 3D Structure View in InterPro
4NTT A 43 - 297 Show 3D Structure View in InterPro
B 43 - 297 Show 3D Structure View in InterPro
4O21 A 43 - 297 Show 3D Structure View in InterPro
4O22 A 43 - 297 Show 3D Structure View in InterPro
4WBB B 43 - 297 Show 3D Structure View in InterPro
4X6Q C 43 - 297 Show 3D Structure View in InterPro
4X6R A 43 - 297 Show 3D Structure View in InterPro
4XW4 A 43 - 297 Show 3D Structure View in InterPro
4XW5 A 43 - 297 Show 3D Structure View in InterPro
4XW6 A 43 - 297 Show 3D Structure View in InterPro
5JR7 A 43 - 297 Show 3D Structure View in InterPro
C 43 - 297 Show 3D Structure View in InterPro
5X3F B 182 - 436 Show 3D Structure View in InterPro
6E21 A 43 - 297 Show 3D Structure View in InterPro
6MM5 E 43 - 297 Show 3D Structure View in InterPro
6MM6 C 43 - 297 Show 3D Structure View in InterPro
E 43 - 297 Show 3D Structure View in InterPro
6MM7 A 43 - 297 Show 3D Structure View in InterPro
D 43 - 297 Show 3D Structure View in InterPro
6MM8 C 43 - 297 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;