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6  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: HEP2_HUMAN (P05546)

Summary

This is the summary of UniProt entry HEP2_HUMAN (P05546).

Description: Heparin cofactor 2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 499 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 19
disorder n/a 24 43
disorder n/a 65 68
low_complexity n/a 71 82
Pfam Serpin 129 496

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P05546. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MKHSLNALLI FLIITSAWGG SKGPLDQLEK GGETAQSADP QWEQLNNKNL
50
51
SMPLLPADFH KENTVTNDWI PEGEEDDDYL DLEKIFSEDD DYIDIVDSLS
100
101
VSPTDSDVSA GNILQLFHGK SRIQRLNILN AKFAFNLYRV LKDQVNTFDN
150
151
IFIAPVGIST AMGMISLGLK GETHEQVHSI LHFKDFVNAS SKYEITTIHN
200
201
LFRKLTHRLF RRNFGYTLRS VNDLYIQKQF PILLDFKTKV REYYFAEAQI
250
251
ADFSDPAFIS KTNNHIMKLT KGLIKDALEN IDPATQMMIL NCIYFKGSWV
300
301
NKFPVEMTHN HNFRLNEREV VKVSMMQTKG NFLAANDQEL DCDILQLEYV
350
351
GGISMLIVVP HKMSGMKTLE AQLTPRVVER WQKSMTNRTR EVLLPKFKLE
400
401
KNYNLVESLK LMGIRMLFDK NGNMAGISDQ RIAIDLFKHQ GTITVNEEGT
450
451
QATTVTTVGF MPLSTQVRFT VDRPFLFLIY EHRTSCLLFM GRVANPSRS 
499
 

Show the unformatted sequence.

Checksums:
CRC64:3B0E353FE1F6DF05
MD5:55e1cfaea1c67c8d5b264889a9fa9043

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Serpin 129 - 496 1JMJ A 110 - 477 Jmol OpenAstexViewer
B 110 - 477 Jmol OpenAstexViewer
1JMO A 110 - 477 Jmol OpenAstexViewer
189 - 212 2NCW A 1 - 24 Jmol OpenAstexViewer
192 - 212 2NCU A 1 - 21 Jmol OpenAstexViewer
2NCV A 1 - 21 Jmol OpenAstexViewer
192 - 219 2NAT A 1 - 28 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.