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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: K1C18_HUMAN (P05783)

Summary

This is the summary of UniProt entry K1C18_HUMAN (P05783).

Description: Keratin, type I cytoskeletal 18
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 430 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
low_complexity n/a 29 44
low_complexity n/a 38 55
disorder n/a 48 51
low_complexity n/a 56 77
coiled_coil n/a 77 118
disorder n/a 78 79
Pfam Filament 79 391
disorder n/a 106 114
coiled_coil n/a 189 227
coiled_coil n/a 249 269
disorder n/a 282 284
disorder n/a 286 287
coiled_coil n/a 289 355
disorder n/a 293 294
disorder n/a 353 354
disorder n/a 356 357
coiled_coil n/a 363 383
disorder n/a 395 399
disorder n/a 403 407
disorder n/a 413 416
disorder n/a 429 430

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P05783. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSFTTRSTFS TNYRSLGSVQ APSYGARPVS SAASVYAGAG GSGSRISVSR
50
51
STSFRGGMGS GGLATGIAGG LAGMGGIQNE KETMQSLNDR LASYLDRVRS
100
101
LETENRRLES KIREHLEKKG PQVRDWSHYF KIIEDLRAQI FANTVDNARI
150
151
VLQIDNARLA ADDFRVKYET ELAMRQSVEN DIHGLRKVID DTNITRLQLE
200
201
TEIEALKEEL LFMKKNHEEE VKGLQAQIAS SGLTVEVDAP KSQDLAKIMA
250
251
DIRAQYDELA RKNREELDKY WSQQIEESTT VVTTQSAEVG AAETTLTELR
300
301
RTVQSLEIDL DSMRNLKASL ENSLREVEAR YALQMEQLNG ILLHLESELA
350
351
QTRAEGQRQA QEYEALLNIK VKLEAEIATY RRLLEDGEDF NLGDALDSSN
400
401
SMQTIQKTTT RRIVDGKVVS ETNDTKVLRH                      
430
 

Show the unformatted sequence.

Checksums:
CRC64:1E5604C6BCC7A17A
MD5:bbe20ef976511e281f6e96463439d449

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;