Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
53  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: LCK_HUMAN (P06239)

Summary

This is the summary of UniProt entry LCK_HUMAN (P06239).

Description: Tyrosine-protein kinase Lck EC=2.7.10.2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 509 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 48 55
Pfam SH3_1 67 113
disorder n/a 83 85
Pfam SH2 127 209
disorder n/a 139 140
disorder n/a 220 221
disorder n/a 231 233
Pfam PK_Tyr_Ser-Thr 245 494
disorder n/a 508 509

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P06239. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGCGCSSHPE DDWMENIDVC ENCHYPIVPL DGKGTLLIRN GSEVRDPLVT
50
51
YEGSNPPASP LQDNLVIALH SYEPSHDGDL GFEKGEQLRI LEQSGEWWKA
100
101
QSLTTGQEGF IPFNFVAKAN SLEPEPWFFK NLSRKDAERQ LLAPGNTHGS
150
151
FLIRESESTA GSFSLSVRDF DQNQGEVVKH YKIRNLDNGG FYISPRITFP
200
201
GLHELVRHYT NASDGLCTRL SRPCQTQKPQ KPWWEDEWEV PRETLKLVER
250
251
LGAGQFGEVW MGYYNGHTKV AVKSLKQGSM SPDAFLAEAN LMKQLQHQRL
300
301
VRLYAVVTQE PIYIITEYME NGSLVDFLKT PSGIKLTINK LLDMAAQIAE
350
351
GMAFIEERNY IHRDLRAANI LVSDTLSCKI ADFGLARLIE DNEYTAREGA
400
401
KFPIKWTAPE AINYGTFTIK SDVWSFGILL TEIVTHGRIP YPGMTNPEVI
450
451
QNLERGYRMV RPDNCPEELY QLMRLCWKER PEDRPTFDYL RSVLEDFFTA
500
501
TEGQYQPQP                                             
509
 

Show the unformatted sequence.

Checksums:
CRC64:44BFF0D43FFB420D
MD5:4da4a28a5ddea0c62c113e19a4a784f7

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
PK_Tyr_Ser-Thr 245 - 494 1QPC A 245 - 494 Show 3D Structure View in InterPro
1QPD A 245 - 494 Show 3D Structure View in InterPro
1QPE A 245 - 494 Show 3D Structure View in InterPro
1QPJ A 245 - 494 Show 3D Structure View in InterPro
2OF2 A 245 - 494 Show 3D Structure View in InterPro
2OF4 A 245 - 494 Show 3D Structure View in InterPro
2OFU A 245 - 494 Show 3D Structure View in InterPro
2OFV A 245 - 494 Show 3D Structure View in InterPro
B 245 - 494 Show 3D Structure View in InterPro
2OG8 A 245 - 494 Show 3D Structure View in InterPro
B 245 - 494 Show 3D Structure View in InterPro
2PL0 A 245 - 494 Show 3D Structure View in InterPro
2ZM1 A 245 - 494 Show 3D Structure View in InterPro
2ZM4 A 245 - 494 Show 3D Structure View in InterPro
2ZYB A 245 - 494 Show 3D Structure View in InterPro
3AC1 A 245 - 494 Show 3D Structure View in InterPro
3AC2 A 245 - 494 Show 3D Structure View in InterPro
3AC3 A 245 - 494 Show 3D Structure View in InterPro
3AC4 A 245 - 494 Show 3D Structure View in InterPro
3AC5 A 245 - 494 Show 3D Structure View in InterPro
3AC8 A 245 - 494 Show 3D Structure View in InterPro
3ACJ A 245 - 494 Show 3D Structure View in InterPro
3ACK A 245 - 494 Show 3D Structure View in InterPro
3AD4 A 245 - 494 Show 3D Structure View in InterPro
3AD5 A 245 - 494 Show 3D Structure View in InterPro
3AD6 A 245 - 494 Show 3D Structure View in InterPro
3B2W A 245 - 494 Show 3D Structure View in InterPro
3BYM A 245 - 494 Show 3D Structure View in InterPro
3BYO A 245 - 494 Show 3D Structure View in InterPro
3BYS A 245 - 494 Show 3D Structure View in InterPro
3BYU A 245 - 494 Show 3D Structure View in InterPro
3KMM A 245 - 494 Show 3D Structure View in InterPro
3KXZ A 245 - 494 Show 3D Structure View in InterPro
3LCK A 245 - 494 Show 3D Structure View in InterPro
3MPM A 245 - 494 Show 3D Structure View in InterPro
4C3F A 245 - 494 Show 3D Structure View in InterPro
6PDJ A 245 - 494 Show 3D Structure View in InterPro
391 - 394 3BRH D 391 - 394 Show 3D Structure View in InterPro
391 - 397 3BRH C 391 - 397 Show 3D Structure View in InterPro
SH2 127 - 209 1BHF A 127 - 209 Show 3D Structure View in InterPro
1BHH A 127 - 209 Show 3D Structure View in InterPro
B 127 - 209 Show 3D Structure View in InterPro
1CWD L 5 - 87 Show 3D Structure View in InterPro
1CWE A 5 - 87 Show 3D Structure View in InterPro
C 5 - 87 Show 3D Structure View in InterPro
1FBZ A 5 - 87 Show 3D Structure View in InterPro
B 205 - 287 Show 3D Structure View in InterPro
1IJR A 5 - 87 Show 3D Structure View in InterPro
1LCJ A 127 - 209 Show 3D Structure View in InterPro
1LCK A 127 - 209 Show 3D Structure View in InterPro
1LKK A 127 - 209 Show 3D Structure View in InterPro
1LKL A 127 - 209 Show 3D Structure View in InterPro
1X27 A 127 - 209 Show 3D Structure View in InterPro
B 127 - 209 Show 3D Structure View in InterPro
C 127 - 209 Show 3D Structure View in InterPro
D 127 - 209 Show 3D Structure View in InterPro
E 127 - 209 Show 3D Structure View in InterPro
F 127 - 209 Show 3D Structure View in InterPro
4D8K A 127 - 209 Show 3D Structure View in InterPro
5MTM A 12 - 94 Show 3D Structure View in InterPro
5MTN A 12 - 94 Show 3D Structure View in InterPro
SH3_1 67 - 113 1H92 A 10 - 56 Show 3D Structure View in InterPro
1KIK A 67 - 113 Show 3D Structure View in InterPro
1LCK A 67 - 113 Show 3D Structure View in InterPro
1X27 A 67 - 113 Show 3D Structure View in InterPro
B 67 - 113 Show 3D Structure View in InterPro
C 67 - 113 Show 3D Structure View in InterPro
D 67 - 113 Show 3D Structure View in InterPro
E 67 - 113 Show 3D Structure View in InterPro
F 67 - 113 Show 3D Structure View in InterPro
2IIM A 67 - 113 Show 3D Structure View in InterPro
4D8K A 67 - 113 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;