Summary
This is the summary of UniProt entry LCK_HUMAN (P06239).
Description: | Tyrosine-protein kinase Lck EC=2.7.10.2 |
Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
|
Length: | 509 amino acids |
Reference Proteome: |
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Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
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Source | Domain | Start | End |
---|---|---|---|
disorder | n/a | 48 | 55 |
Pfam | SH3_1 | 67 | 113 |
disorder | n/a | 83 | 85 |
Pfam | SH2 | 127 | 209 |
disorder | n/a | 139 | 140 |
disorder | n/a | 220 | 221 |
disorder | n/a | 231 | 233 |
Pfam | PK_Tyr_Ser-Thr | 245 | 494 |
disorder | n/a | 508 | 509 |
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession P06239. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
Sequence: | 1
MGCGCSSHPE DDWMENIDVC ENCHYPIVPL DGKGTLLIRN GSEVRDPLVT
50 51
YEGSNPPASP LQDNLVIALH SYEPSHDGDL GFEKGEQLRI LEQSGEWWKA
100 101
QSLTTGQEGF IPFNFVAKAN SLEPEPWFFK NLSRKDAERQ LLAPGNTHGS
150 151
FLIRESESTA GSFSLSVRDF DQNQGEVVKH YKIRNLDNGG FYISPRITFP
200 201
GLHELVRHYT NASDGLCTRL SRPCQTQKPQ KPWWEDEWEV PRETLKLVER
250 251
LGAGQFGEVW MGYYNGHTKV AVKSLKQGSM SPDAFLAEAN LMKQLQHQRL
300 301
VRLYAVVTQE PIYIITEYME NGSLVDFLKT PSGIKLTINK LLDMAAQIAE
350 351
GMAFIEERNY IHRDLRAANI LVSDTLSCKI ADFGLARLIE DNEYTAREGA
400 401
KFPIKWTAPE AINYGTFTIK SDVWSFGILL TEIVTHGRIP YPGMTNPEVI
450 451
QNLERGYRMV RPDNCPEELY QLMRLCWKER PEDRPTFDYL RSVLEDFFTA
500 501
TEGQYQPQP
509
Show the unformatted sequence. |
Checksums: |
CRC64:44BFF0D43FFB420D
MD5:4da4a28a5ddea0c62c113e19a4a784f7
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.