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53  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: LCK_HUMAN (P06239)

Summary

This is the summary of UniProt entry LCK_HUMAN (P06239).

Description: Tyrosine-protein kinase Lck EC=2.7.10.2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 509 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 48 55
Pfam SH3_1 67 113
disorder n/a 83 85
Pfam SH2 127 209
disorder n/a 139 140
disorder n/a 220 221
disorder n/a 231 233
Pfam PK_Tyr_Ser-Thr 245 494
disorder n/a 508 509

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P06239. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGCGCSSHPE DDWMENIDVC ENCHYPIVPL DGKGTLLIRN GSEVRDPLVT
50
51
YEGSNPPASP LQDNLVIALH SYEPSHDGDL GFEKGEQLRI LEQSGEWWKA
100
101
QSLTTGQEGF IPFNFVAKAN SLEPEPWFFK NLSRKDAERQ LLAPGNTHGS
150
151
FLIRESESTA GSFSLSVRDF DQNQGEVVKH YKIRNLDNGG FYISPRITFP
200
201
GLHELVRHYT NASDGLCTRL SRPCQTQKPQ KPWWEDEWEV PRETLKLVER
250
251
LGAGQFGEVW MGYYNGHTKV AVKSLKQGSM SPDAFLAEAN LMKQLQHQRL
300
301
VRLYAVVTQE PIYIITEYME NGSLVDFLKT PSGIKLTINK LLDMAAQIAE
350
351
GMAFIEERNY IHRDLRAANI LVSDTLSCKI ADFGLARLIE DNEYTAREGA
400
401
KFPIKWTAPE AINYGTFTIK SDVWSFGILL TEIVTHGRIP YPGMTNPEVI
450
451
QNLERGYRMV RPDNCPEELY QLMRLCWKER PEDRPTFDYL RSVLEDFFTA
500
501
TEGQYQPQP                                             
509
 

Show the unformatted sequence.

Checksums:
CRC64:44BFF0D43FFB420D
MD5:4da4a28a5ddea0c62c113e19a4a784f7

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
PK_Tyr_Ser-Thr 245 - 494 1QPC A 245 - 494 Jmol OpenAstexViewer
1QPD A 245 - 494 Jmol OpenAstexViewer
1QPE A 245 - 494 Jmol OpenAstexViewer
1QPJ A 245 - 494 Jmol OpenAstexViewer
2OF2 A 245 - 494 Jmol OpenAstexViewer
2OF4 A 245 - 494 Jmol OpenAstexViewer
2OFU A 245 - 494 Jmol OpenAstexViewer
2OFV A 245 - 494 Jmol OpenAstexViewer
B 245 - 494 Jmol OpenAstexViewer
2OG8 A 245 - 494 Jmol OpenAstexViewer
B 245 - 494 Jmol OpenAstexViewer
2PL0 A 245 - 494 Jmol OpenAstexViewer
2ZM1 A 245 - 494 Jmol OpenAstexViewer
2ZM4 A 245 - 494 Jmol OpenAstexViewer
2ZYB A 245 - 494 Jmol OpenAstexViewer
3AC1 A 245 - 494 Jmol OpenAstexViewer
3AC2 A 245 - 494 Jmol OpenAstexViewer
3AC3 A 245 - 494 Jmol OpenAstexViewer
3AC4 A 245 - 494 Jmol OpenAstexViewer
3AC5 A 245 - 494 Jmol OpenAstexViewer
3AC8 A 245 - 494 Jmol OpenAstexViewer
3ACJ A 245 - 494 Jmol OpenAstexViewer
3ACK A 245 - 494 Jmol OpenAstexViewer
3AD4 A 245 - 494 Jmol OpenAstexViewer
3AD5 A 245 - 494 Jmol OpenAstexViewer
3AD6 A 245 - 494 Jmol OpenAstexViewer
3B2W A 245 - 494 Jmol OpenAstexViewer
3BYM A 245 - 494 Jmol OpenAstexViewer
3BYO A 245 - 494 Jmol OpenAstexViewer
3BYS A 245 - 494 Jmol OpenAstexViewer
3BYU A 245 - 494 Jmol OpenAstexViewer
3KMM A 245 - 494 Jmol OpenAstexViewer
3KXZ A 245 - 494 Jmol OpenAstexViewer
3LCK A 245 - 494 Jmol OpenAstexViewer
3MPM A 245 - 494 Jmol OpenAstexViewer
4C3F A 245 - 494 Jmol OpenAstexViewer
6PDJ A 245 - 494 Jmol OpenAstexViewer
391 - 394 3BRH D 391 - 394 Jmol OpenAstexViewer
391 - 397 3BRH C 391 - 397 Jmol OpenAstexViewer
SH2 127 - 209 1BHF A 127 - 209 Jmol OpenAstexViewer
1BHH A 127 - 209 Jmol OpenAstexViewer
B 127 - 209 Jmol OpenAstexViewer
1CWD L 5 - 87 Jmol OpenAstexViewer
1CWE A 5 - 87 Jmol OpenAstexViewer
C 5 - 87 Jmol OpenAstexViewer
1FBZ A 5 - 87 Jmol OpenAstexViewer
B 205 - 287 Jmol OpenAstexViewer
1IJR A 5 - 87 Jmol OpenAstexViewer
1LCJ A 127 - 209 Jmol OpenAstexViewer
1LCK A 127 - 209 Jmol OpenAstexViewer
1LKK A 127 - 209 Jmol OpenAstexViewer
1LKL A 127 - 209 Jmol OpenAstexViewer
1X27 A 127 - 209 Jmol OpenAstexViewer
B 127 - 209 Jmol OpenAstexViewer
C 127 - 209 Jmol OpenAstexViewer
D 127 - 209 Jmol OpenAstexViewer
E 127 - 209 Jmol OpenAstexViewer
F 127 - 209 Jmol OpenAstexViewer
4D8K A 127 - 209 Jmol OpenAstexViewer
5MTM A 12 - 94 Jmol OpenAstexViewer
5MTN A 12 - 94 Jmol OpenAstexViewer
SH3_1 67 - 113 1H92 A 10 - 56 Jmol OpenAstexViewer
1KIK A 67 - 113 Jmol OpenAstexViewer
1LCK A 67 - 113 Jmol OpenAstexViewer
1X27 A 67 - 113 Jmol OpenAstexViewer
B 67 - 113 Jmol OpenAstexViewer
C 67 - 113 Jmol OpenAstexViewer
D 67 - 113 Jmol OpenAstexViewer
E 67 - 113 Jmol OpenAstexViewer
F 67 - 113 Jmol OpenAstexViewer
2IIM A 67 - 113 Jmol OpenAstexViewer
4D8K A 67 - 113 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.