Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
21  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: AGAL_HUMAN (P06280)

Summary

This is the summary of UniProt entry AGAL_HUMAN (P06280).

Description: Alpha-galactosidase A {ECO:0000305}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 429 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
sig_p n/a 1 31
Pfam Melibiase_2 39 322
Pfam Melibiase_2_C 325 411

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P06280. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MQLRNPELHL GCALALRFLA LVSWDIPGAR ALDNGLARTP TMGWLHWERF
50
51
MCNLDCQEEP DSCISEKLFM EMAELMVSEG WKDAGYEYLC IDDCWMAPQR
100
101
DSEGRLQADP QRFPHGIRQL ANYVHSKGLK LGIYADVGNK TCAGFPGSFG
150
151
YYDIDAQTFA DWGVDLLKFD GCYCDSLENL ADGYKHMSLA LNRTGRSIVY
200
201
SCEWPLYMWP FQKPNYTEIR QYCNHWRNFA DIDDSWKSIK SILDWTSFNQ
250
251
ERIVDVAGPG GWNDPDMLVI GNFGLSWNQQ VTQMALWAIM AAPLFMSNDL
300
301
RHISPQAKAL LQDKDVIAIN QDPLGKQGYQ LRQGDNFEVW ERPLSGLAWA
350
351
VAMINRQEIG GPRSYTIAVA SLGKGVACNP ACFITQLLPV KRKLGFYEWT
400
401
SRLRSHINPT GTVLLQLENT MQMSLKDLL                       
429
 

Show the unformatted sequence.

Checksums:
CRC64:613F8BF21B107D7B
MD5:870d8e710eb13a4ed9b604b14aa14070

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Melibiase_2 39 - 322 1R46 A 39 - 322 Show 3D Structure View in InterPro
B 39 - 322 Show 3D Structure View in InterPro
1R47 A 39 - 322 Show 3D Structure View in InterPro
B 39 - 322 Show 3D Structure View in InterPro
3GXN A 39 - 322 Show 3D Structure View in InterPro
B 39 - 322 Show 3D Structure View in InterPro
3GXP A 39 - 322 Show 3D Structure View in InterPro
B 39 - 322 Show 3D Structure View in InterPro
3GXT A 39 - 322 Show 3D Structure View in InterPro
B 39 - 322 Show 3D Structure View in InterPro
3HG2 A 39 - 322 Show 3D Structure View in InterPro
B 39 - 322 Show 3D Structure View in InterPro
3HG3 A 39 - 322 Show 3D Structure View in InterPro
B 39 - 322 Show 3D Structure View in InterPro
3HG4 A 39 - 322 Show 3D Structure View in InterPro
B 39 - 322 Show 3D Structure View in InterPro
3HG5 A 39 - 322 Show 3D Structure View in InterPro
B 39 - 322 Show 3D Structure View in InterPro
3LX9 A 39 - 322 Show 3D Structure View in InterPro
B 39 - 322 Show 3D Structure View in InterPro
3LXA A 39 - 322 Show 3D Structure View in InterPro
B 39 - 322 Show 3D Structure View in InterPro
3LXB A 39 - 322 Show 3D Structure View in InterPro
B 39 - 322 Show 3D Structure View in InterPro
3LXC A 39 - 322 Show 3D Structure View in InterPro
B 39 - 322 Show 3D Structure View in InterPro
3S5Y A 39 - 322 Show 3D Structure View in InterPro
B 39 - 322 Show 3D Structure View in InterPro
3S5Z A 39 - 322 Show 3D Structure View in InterPro
B 39 - 322 Show 3D Structure View in InterPro
3TV8 A 39 - 322 Show 3D Structure View in InterPro
B 39 - 322 Show 3D Structure View in InterPro
4NXS A 39 - 322 Show 3D Structure View in InterPro
B 39 - 322 Show 3D Structure View in InterPro
6IBK A 39 - 322 Show 3D Structure View in InterPro
B 39 - 322 Show 3D Structure View in InterPro
6IBM A 39 - 322 Show 3D Structure View in InterPro
B 39 - 322 Show 3D Structure View in InterPro
6IBR A 39 - 322 Show 3D Structure View in InterPro
B 39 - 322 Show 3D Structure View in InterPro
6IBT A 39 - 322 Show 3D Structure View in InterPro
B 39 - 322 Show 3D Structure View in InterPro
Melibiase_2_C 325 - 411 1R46 A 325 - 411 Show 3D Structure View in InterPro
B 325 - 411 Show 3D Structure View in InterPro
1R47 A 325 - 411 Show 3D Structure View in InterPro
B 325 - 411 Show 3D Structure View in InterPro
3GXN A 325 - 411 Show 3D Structure View in InterPro
B 325 - 411 Show 3D Structure View in InterPro
3GXP A 325 - 411 Show 3D Structure View in InterPro
B 325 - 411 Show 3D Structure View in InterPro
3GXT A 325 - 411 Show 3D Structure View in InterPro
B 325 - 411 Show 3D Structure View in InterPro
3HG2 A 325 - 411 Show 3D Structure View in InterPro
B 325 - 411 Show 3D Structure View in InterPro
3HG3 A 325 - 411 Show 3D Structure View in InterPro
B 325 - 411 Show 3D Structure View in InterPro
3HG4 A 325 - 411 Show 3D Structure View in InterPro
B 325 - 411 Show 3D Structure View in InterPro
3HG5 A 325 - 411 Show 3D Structure View in InterPro
B 325 - 411 Show 3D Structure View in InterPro
3LX9 A 325 - 411 Show 3D Structure View in InterPro
B 325 - 411 Show 3D Structure View in InterPro
3LXA A 325 - 411 Show 3D Structure View in InterPro
B 325 - 411 Show 3D Structure View in InterPro
3LXB A 325 - 411 Show 3D Structure View in InterPro
B 325 - 411 Show 3D Structure View in InterPro
3LXC A 325 - 411 Show 3D Structure View in InterPro
B 325 - 411 Show 3D Structure View in InterPro
3S5Y A 325 - 411 Show 3D Structure View in InterPro
B 325 - 411 Show 3D Structure View in InterPro
3S5Z A 325 - 411 Show 3D Structure View in InterPro
B 325 - 411 Show 3D Structure View in InterPro
3TV8 A 325 - 411 Show 3D Structure View in InterPro
B 325 - 411 Show 3D Structure View in InterPro
4NXS A 325 - 411 Show 3D Structure View in InterPro
B 325 - 411 Show 3D Structure View in InterPro
6IBK A 325 - 411 Show 3D Structure View in InterPro
B 325 - 411 Show 3D Structure View in InterPro
6IBM A 325 - 411 Show 3D Structure View in InterPro
B 325 - 411 Show 3D Structure View in InterPro
6IBR A 325 - 411 Show 3D Structure View in InterPro
B 325 - 411 Show 3D Structure View in InterPro
6IBT A 325 - 411 Show 3D Structure View in InterPro
B 325 - 411 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;