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32  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ITAV_HUMAN (P06756)

Summary

This is the summary of UniProt entry ITAV_HUMAN (P06756).

Description: Integrin alpha-V
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1048 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 30
low_complexity n/a 4 27
Pfam FG-GAP 252 286
Pfam FG-GAP 306 348
Pfam FG-GAP 370 406
Pfam Integrin_alpha2 467 914
disorder n/a 786 808
disorder n/a 872 882
transmembrane n/a 994 1016
low_complexity n/a 999 1012
Pfam Integrin_alpha 1017 1031
low_complexity n/a 1023 1038
disorder n/a 1027 1048

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P06756. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAFPPRRRLR LGPRGLPLLL SGLLLPLCRA FNLDVDSPAE YSGPEGSYFG
50
51
FAVDFFVPSA SSRMFLLVGA PKANTTQPGI VEGGQVLKCD WSSTRRCQPI
100
101
EFDATGNRDY AKDDPLEFKS HQWFGASVRS KQDKILACAP LYHWRTEMKQ
150
151
EREPVGTCFL QDGTKTVEYA PCRSQDIDAD GQGFCQGGFS IDFTKADRVL
200
201
LGGPGSFYWQ GQLISDQVAE IVSKYDPNVY SIKYNNQLAT RTAQAIFDDS
250
251
YLGYSVAVGD FNGDGIDDFV SGVPRAARTL GMVYIYDGKN MSSLYNFTGE
300
301
QMAAYFGFSV AATDINGDDY ADVFIGAPLF MDRGSDGKLQ EVGQVSVSLQ
350
351
RASGDFQTTK LNGFEVFARF GSAIAPLGDL DQDGFNDIAI AAPYGGEDKK
400
401
GIVYIFNGRS TGLNAVPSQI LEGQWAARSM PPSFGYSMKG ATDIDKNGYP
450
451
DLIVGAFGVD RAILYRARPV ITVNAGLEVY PSILNQDNKT CSLPGTALKV
500
501
SCFNVRFCLK ADGKGVLPRK LNFQVELLLD KLKQKGAIRR ALFLYSRSPS
550
551
HSKNMTISRG GLMQCEELIA YLRDESEFRD KLTPITIFME YRLDYRTAAD
600
601
TTGLQPILNQ FTPANISRQA HILLDCGEDN VCKPKLEVSV DSDQKKIYIG
650
651
DDNPLTLIVK AQNQGEGAYE AELIVSIPLQ ADFIGVVRNN EALARLSCAF
700
701
KTENQTRQVV CDLGNPMKAG TQLLAGLRFS VHQQSEMDTS VKFDLQIQSS
750
751
NLFDKVSPVV SHKVDLAVLA AVEIRGVSSP DHVFLPIPNW EHKENPETEE
800
801
DVGPVVQHIY ELRNNGPSSF SKAMLHLQWP YKYNNNTLLY ILHYDIDGPM
850
851
NCTSDMEINP LRIKISSLQT TEKNDTVAGQ GERDHLITKR DLALSEGDIH
900
901
TLGCGVAQCL KIVCQVGRLD RGKSAILYVK SLLWTETFMN KENQNHSYSL
950
951
KSSASFNVIE FPYKNLPIED ITNSTLVTTN VTWGIQPAPM PVPVWVIILA
1000
1001
VLAGLLLLAV LVFVMYRMGF FKRVRPPQEE QEREQLQPHE NGEGNSET  
1048
 

Show the unformatted sequence.

Checksums:
CRC64:364EE25C5303A2D7
MD5:915fe32307fb678af3b3d97be8411ab5

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
FG-GAP 252 - 286 1JV2 A 222 - 256 Show 3D Structure View in InterPro
1L5G A 222 - 256 Show 3D Structure View in InterPro
1M1X A 222 - 256 Show 3D Structure View in InterPro
1U8C A 222 - 256 Show 3D Structure View in InterPro
3IJE A 222 - 256 Show 3D Structure View in InterPro
4G1E A 222 - 256 Show 3D Structure View in InterPro
4G1M A 222 - 256 Show 3D Structure View in InterPro
4MMX A 222 - 256 Show 3D Structure View in InterPro
4MMY A 222 - 256 Show 3D Structure View in InterPro
4MMZ A 222 - 256 Show 3D Structure View in InterPro
4O02 A 222 - 256 Show 3D Structure View in InterPro
4UM8 A 222 - 256 Show 3D Structure View in InterPro
C 222 - 256 Show 3D Structure View in InterPro
4UM9 A 222 - 256 Show 3D Structure View in InterPro
C 222 - 256 Show 3D Structure View in InterPro
5FFG A 222 - 256 Show 3D Structure View in InterPro
5FFO A 222 - 256 Show 3D Structure View in InterPro
E 222 - 256 Show 3D Structure View in InterPro
5NEM A 222 - 256 Show 3D Structure View in InterPro
5NER A 222 - 256 Show 3D Structure View in InterPro
5NET A 222 - 256 Show 3D Structure View in InterPro
5NEU A 222 - 256 Show 3D Structure View in InterPro
6AVQ A 222 - 256 Show 3D Structure View in InterPro
6AVR A 222 - 256 Show 3D Structure View in InterPro
6AVU A 222 - 256 Show 3D Structure View in InterPro
6DJP A 222 - 256 Show 3D Structure View in InterPro
6MK0 A 222 - 256 Show 3D Structure View in InterPro
6MSL A 222 - 256 Show 3D Structure View in InterPro
6MSU A 222 - 256 Show 3D Structure View in InterPro
6NAJ A 222 - 256 Show 3D Structure View in InterPro
6OM1 A 222 - 256 Show 3D Structure View in InterPro
C 222 - 256 Show 3D Structure View in InterPro
E 222 - 256 Show 3D Structure View in InterPro
G 222 - 256 Show 3D Structure View in InterPro
6OM2 A 222 - 256 Show 3D Structure View in InterPro
C 222 - 256 Show 3D Structure View in InterPro
6UJA A 222 - 256 Show 3D Structure View in InterPro
6UJB A 222 - 256 Show 3D Structure View in InterPro
6UJC A 222 - 256 Show 3D Structure View in InterPro
306 - 348 1JV2 A 276 - 318 Show 3D Structure View in InterPro
1L5G A 276 - 318 Show 3D Structure View in InterPro
1M1X A 276 - 318 Show 3D Structure View in InterPro
1U8C A 276 - 318 Show 3D Structure View in InterPro
3IJE A 276 - 318 Show 3D Structure View in InterPro
4G1E A 276 - 318 Show 3D Structure View in InterPro
4G1M A 276 - 318 Show 3D Structure View in InterPro
4MMX A 276 - 318 Show 3D Structure View in InterPro
4MMY A 276 - 318 Show 3D Structure View in InterPro
4MMZ A 276 - 318 Show 3D Structure View in InterPro
4O02 A 276 - 318 Show 3D Structure View in InterPro
4UM8 A 276 - 318 Show 3D Structure View in InterPro
C 276 - 318 Show 3D Structure View in InterPro
4UM9 A 276 - 318 Show 3D Structure View in InterPro
C 276 - 318 Show 3D Structure View in InterPro
5FFG A 276 - 318 Show 3D Structure View in InterPro
5FFO A 276 - 318 Show 3D Structure View in InterPro
E 276 - 318 Show 3D Structure View in InterPro
5NEM A 276 - 318 Show 3D Structure View in InterPro
5NER A 276 - 318 Show 3D Structure View in InterPro
5NET A 276 - 318 Show 3D Structure View in InterPro
5NEU A 276 - 318 Show 3D Structure View in InterPro
6AVQ A 276 - 318 Show 3D Structure View in InterPro
6AVR A 276 - 318 Show 3D Structure View in InterPro
6AVU A 276 - 318 Show 3D Structure View in InterPro
6DJP A 276 - 318 Show 3D Structure View in InterPro
6MK0 A 276 - 318 Show 3D Structure View in InterPro
6MSL A 276 - 318 Show 3D Structure View in InterPro
6MSU A 276 - 318 Show 3D Structure View in InterPro
6NAJ A 276 - 318 Show 3D Structure View in InterPro
6OM1 A 276 - 318 Show 3D Structure View in InterPro
C 276 - 318 Show 3D Structure View in InterPro
E 276 - 318 Show 3D Structure View in InterPro
G 276 - 318 Show 3D Structure View in InterPro
6OM2 A 276 - 318 Show 3D Structure View in InterPro
C 276 - 318 Show 3D Structure View in InterPro
6UJA A 276 - 318 Show 3D Structure View in InterPro
6UJB A 276 - 318 Show 3D Structure View in InterPro
6UJC A 276 - 318 Show 3D Structure View in InterPro
370 - 406 1JV2 A 340 - 376 Show 3D Structure View in InterPro
1L5G A 340 - 376 Show 3D Structure View in InterPro
1M1X A 340 - 376 Show 3D Structure View in InterPro
1U8C A 340 - 376 Show 3D Structure View in InterPro
3IJE A 340 - 376 Show 3D Structure View in InterPro
4G1E A 340 - 376 Show 3D Structure View in InterPro
4G1M A 340 - 376 Show 3D Structure View in InterPro
4MMX A 340 - 376 Show 3D Structure View in InterPro
4MMY A 340 - 376 Show 3D Structure View in InterPro
4MMZ A 340 - 376 Show 3D Structure View in InterPro
4O02 A 340 - 376 Show 3D Structure View in InterPro
4UM8 A 340 - 376 Show 3D Structure View in InterPro
C 340 - 376 Show 3D Structure View in InterPro
4UM9 A 340 - 376 Show 3D Structure View in InterPro
C 340 - 376 Show 3D Structure View in InterPro
5FFG A 340 - 376 Show 3D Structure View in InterPro
5FFO A 340 - 376 Show 3D Structure View in InterPro
E 340 - 376 Show 3D Structure View in InterPro
5NEM A 340 - 376 Show 3D Structure View in InterPro
5NER A 340 - 376 Show 3D Structure View in InterPro
5NET A 340 - 376 Show 3D Structure View in InterPro
5NEU A 340 - 376 Show 3D Structure View in InterPro
6AVQ A 340 - 376 Show 3D Structure View in InterPro
6AVR A 340 - 376 Show 3D Structure View in InterPro
6AVU A 340 - 376 Show 3D Structure View in InterPro
6DJP A 340 - 376 Show 3D Structure View in InterPro
6MK0 A 340 - 376 Show 3D Structure View in InterPro
6MSL A 340 - 376 Show 3D Structure View in InterPro
6MSU A 340 - 376 Show 3D Structure View in InterPro
6NAJ A 340 - 376 Show 3D Structure View in InterPro
6OM1 A 340 - 376 Show 3D Structure View in InterPro
C 340 - 376 Show 3D Structure View in InterPro
E 340 - 376 Show 3D Structure View in InterPro
G 340 - 376 Show 3D Structure View in InterPro
6OM2 A 340 - 376 Show 3D Structure View in InterPro
C 340 - 376 Show 3D Structure View in InterPro
6UJA A 340 - 376 Show 3D Structure View in InterPro
6UJB A 340 - 376 Show 3D Structure View in InterPro
6UJC A 340 - 376 Show 3D Structure View in InterPro
Integrin_alpha2 467 - 620 5FFO E 438 - 591 Show 3D Structure View in InterPro
467 - 623 5FFG A 438 - 594 Show 3D Structure View in InterPro
6DJP A 437 - 593 Show 3D Structure View in InterPro
6UJA A 437 - 593 Show 3D Structure View in InterPro
6UJB A 437 - 593 Show 3D Structure View in InterPro
6UJC A 437 - 593 Show 3D Structure View in InterPro
467 - 624 4UM8 A 437 - 594 Show 3D Structure View in InterPro
C 437 - 594 Show 3D Structure View in InterPro
4UM9 A 437 - 594 Show 3D Structure View in InterPro
C 437 - 594 Show 3D Structure View in InterPro
5NEM A 437 - 594 Show 3D Structure View in InterPro
5NER A 437 - 594 Show 3D Structure View in InterPro
5NET A 437 - 594 Show 3D Structure View in InterPro
5NEU A 437 - 594 Show 3D Structure View in InterPro
6OM1 A 438 - 595 Show 3D Structure View in InterPro
C 438 - 595 Show 3D Structure View in InterPro
E 438 - 595 Show 3D Structure View in InterPro
G 438 - 595 Show 3D Structure View in InterPro
6OM2 A 438 - 595 Show 3D Structure View in InterPro
C 438 - 595 Show 3D Structure View in InterPro
467 - 625 5FFO A 438 - 596 Show 3D Structure View in InterPro
467 - 914 1JV2 A 437 - 884 Show 3D Structure View in InterPro
1L5G A 437 - 884 Show 3D Structure View in InterPro
1M1X A 437 - 884 Show 3D Structure View in InterPro
1U8C A 437 - 884 Show 3D Structure View in InterPro
3IJE A 437 - 884 Show 3D Structure View in InterPro
4G1E A 437 - 884 Show 3D Structure View in InterPro
4G1M A 437 - 884 Show 3D Structure View in InterPro
4MMX A 437 - 884 Show 3D Structure View in InterPro
4MMY A 437 - 884 Show 3D Structure View in InterPro
4MMZ A 437 - 884 Show 3D Structure View in InterPro
4O02 A 437 - 884 Show 3D Structure View in InterPro
6AVQ A 437 - 884 Show 3D Structure View in InterPro
6AVR A 437 - 884 Show 3D Structure View in InterPro
6AVU A 437 - 884 Show 3D Structure View in InterPro
6MK0 A 437 - 884 Show 3D Structure View in InterPro
6MSL A 437 - 884 Show 3D Structure View in InterPro
6MSU A 437 - 884 Show 3D Structure View in InterPro
6NAJ A 437 - 884 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;