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31  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DPOLB_RAT (P06766)

Summary

This is the summary of UniProt entry DPOLB_RAT (P06766).

Description: DNA polymerase beta EC=2.7.7.7 EC=4.2.99.-
Source organism: Rattus norvegicus (Rat) (NCBI taxonomy ID 10116)
Length: 335 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 8
Pfam HHH_8 12 78
Pfam DNA_pol_lambd_f 98 147
disorder n/a 125 126
Pfam DNA_pol_B_palm 149 262
disorder n/a 192 198
disorder n/a 240 242
disorder n/a 252 253
Pfam DNA_pol_B_thumb 268 334
disorder n/a 334 335

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P06766. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSKRKAPQET LNGGITDMLV ELANFEKNVS QAIHKYNAYR KAASVIAKYP
50
51
HKIKSGAEAK KLPGVGTKIA EKIDEFLATG KLRKLEKIRQ DDTSSSINFL
100
101
TRVTGIGPSA ARKLVDEGIK TLEDLRKNED KLNHHQRIGL KYFEDFEKRI
150
151
PREEMLQMQD IVLNEVKKLD PEYIATVCGS FRRGAESSGD MDVLLTHPNF
200
201
TSESSKQPKL LHRVVEQLQK VRFITDTLSK GETKFMGVCQ LPSENDENEY
250
251
PHRRIDIRLI PKDQYYCGVL YFTGSDIFNK NMRAHALEKG FTINEYTIRP
300
301
LGVTGVAGEP LPVDSEQDIF DYIQWRYREP KDRSE                
335
 

Show the unformatted sequence.

Checksums:
CRC64:BBF8498C0D3FBFC9
MD5:8c1e67470da4981864dbb979cad9df91

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
DNA_pol_B_palm 149 - 262 1BPB A 149 - 262 Show 3D Structure View in InterPro
1BPD A 149 - 262 Show 3D Structure View in InterPro
1BPE A 149 - 262 Show 3D Structure View in InterPro
1HUO A 149 - 262 Show 3D Structure View in InterPro
B 149 - 262 Show 3D Structure View in InterPro
1HUZ A 149 - 262 Show 3D Structure View in InterPro
B 149 - 262 Show 3D Structure View in InterPro
1JN3 A 149 - 262 Show 3D Structure View in InterPro
1NOM A 149 - 262 Show 3D Structure View in InterPro
1RPL A 149 - 262 Show 3D Structure View in InterPro
1ZQU A 149 - 262 Show 3D Structure View in InterPro
1ZQV A 149 - 262 Show 3D Structure View in InterPro
1ZQW A 149 - 262 Show 3D Structure View in InterPro
1ZQX A 149 - 262 Show 3D Structure View in InterPro
1ZQY A 149 - 262 Show 3D Structure View in InterPro
1ZQZ A 149 - 262 Show 3D Structure View in InterPro
2BPC A 149 - 262 Show 3D Structure View in InterPro
2BPF A 149 - 262 Show 3D Structure View in InterPro
2BPG A 149 - 262 Show 3D Structure View in InterPro
B 149 - 262 Show 3D Structure View in InterPro
2VAN A 149 - 262 Show 3D Structure View in InterPro
3K75 D 149 - 262 Show 3D Structure View in InterPro
E 149 - 262 Show 3D Structure View in InterPro
3LQC B 149 - 262 Show 3D Structure View in InterPro
3UXN A 149 - 262 Show 3D Structure View in InterPro
B 149 - 262 Show 3D Structure View in InterPro
3UXO A 149 - 262 Show 3D Structure View in InterPro
B 149 - 262 Show 3D Structure View in InterPro
3UXP A 149 - 262 Show 3D Structure View in InterPro
B 149 - 262 Show 3D Structure View in InterPro
3V72 A 149 - 262 Show 3D Structure View in InterPro
3V7J A 149 - 262 Show 3D Structure View in InterPro
3V7K A 149 - 262 Show 3D Structure View in InterPro
3V7L A 149 - 262 Show 3D Structure View in InterPro
DNA_pol_B_thumb 268 - 334 1BPB A 268 - 334 Show 3D Structure View in InterPro
1BPD A 268 - 334 Show 3D Structure View in InterPro
1BPE A 268 - 334 Show 3D Structure View in InterPro
1HUO A 268 - 334 Show 3D Structure View in InterPro
B 268 - 334 Show 3D Structure View in InterPro
1HUZ A 268 - 334 Show 3D Structure View in InterPro
B 268 - 334 Show 3D Structure View in InterPro
1JN3 A 268 - 334 Show 3D Structure View in InterPro
1NOM A 268 - 334 Show 3D Structure View in InterPro
1RPL A 268 - 334 Show 3D Structure View in InterPro
1ZQU A 268 - 334 Show 3D Structure View in InterPro
1ZQV A 268 - 334 Show 3D Structure View in InterPro
1ZQW A 268 - 334 Show 3D Structure View in InterPro
1ZQX A 268 - 334 Show 3D Structure View in InterPro
1ZQY A 268 - 334 Show 3D Structure View in InterPro
1ZQZ A 268 - 334 Show 3D Structure View in InterPro
2BPC A 268 - 334 Show 3D Structure View in InterPro
2BPF A 268 - 334 Show 3D Structure View in InterPro
2BPG A 268 - 334 Show 3D Structure View in InterPro
B 268 - 334 Show 3D Structure View in InterPro
2VAN A 268 - 334 Show 3D Structure View in InterPro
3K75 D 268 - 334 Show 3D Structure View in InterPro
E 268 - 334 Show 3D Structure View in InterPro
3LQC B 268 - 334 Show 3D Structure View in InterPro
3UXN A 268 - 334 Show 3D Structure View in InterPro
B 268 - 334 Show 3D Structure View in InterPro
3UXO A 268 - 334 Show 3D Structure View in InterPro
B 268 - 334 Show 3D Structure View in InterPro
3UXP A 268 - 334 Show 3D Structure View in InterPro
B 268 - 334 Show 3D Structure View in InterPro
3V72 A 268 - 334 Show 3D Structure View in InterPro
3V7J A 268 - 334 Show 3D Structure View in InterPro
3V7K A 268 - 334 Show 3D Structure View in InterPro
3V7L A 268 - 334 Show 3D Structure View in InterPro
DNA_pol_lambd_f 142 - 147 3LQC B 142 - 147 Show 3D Structure View in InterPro
98 - 147 1BPB A 98 - 147 Show 3D Structure View in InterPro
1BPD A 98 - 147 Show 3D Structure View in InterPro
1BPE A 98 - 147 Show 3D Structure View in InterPro
1HUO A 98 - 147 Show 3D Structure View in InterPro
B 98 - 147 Show 3D Structure View in InterPro
1HUZ A 98 - 147 Show 3D Structure View in InterPro
B 98 - 147 Show 3D Structure View in InterPro
1JN3 A 98 - 147 Show 3D Structure View in InterPro
1NOM A 98 - 147 Show 3D Structure View in InterPro
1RPL A 98 - 147 Show 3D Structure View in InterPro
1ZQU A 98 - 147 Show 3D Structure View in InterPro
1ZQV A 98 - 147 Show 3D Structure View in InterPro
1ZQW A 98 - 147 Show 3D Structure View in InterPro
1ZQX A 98 - 147 Show 3D Structure View in InterPro
1ZQY A 98 - 147 Show 3D Structure View in InterPro
1ZQZ A 98 - 147 Show 3D Structure View in InterPro
2BPC A 98 - 147 Show 3D Structure View in InterPro
2BPF A 98 - 147 Show 3D Structure View in InterPro
2BPG A 98 - 147 Show 3D Structure View in InterPro
B 98 - 147 Show 3D Structure View in InterPro
2VAN A 98 - 147 Show 3D Structure View in InterPro
3K75 D 98 - 147 Show 3D Structure View in InterPro
E 98 - 147 Show 3D Structure View in InterPro
3UXN A 98 - 147 Show 3D Structure View in InterPro
B 98 - 147 Show 3D Structure View in InterPro
3UXO A 98 - 147 Show 3D Structure View in InterPro
B 98 - 147 Show 3D Structure View in InterPro
3UXP A 98 - 147 Show 3D Structure View in InterPro
B 98 - 147 Show 3D Structure View in InterPro
3V72 A 98 - 147 Show 3D Structure View in InterPro
3V7J A 98 - 147 Show 3D Structure View in InterPro
3V7K A 98 - 147 Show 3D Structure View in InterPro
3V7L A 98 - 147 Show 3D Structure View in InterPro
HHH_8 12 - 78 1BNO A 12 - 78 Show 3D Structure View in InterPro
1BNP A 12 - 78 Show 3D Structure View in InterPro
1BPD A 12 - 78 Show 3D Structure View in InterPro
1BPE A 12 - 78 Show 3D Structure View in InterPro
1DK2 A 12 - 78 Show 3D Structure View in InterPro
1DK3 A 12 - 78 Show 3D Structure View in InterPro
1HUO A 12 - 78 Show 3D Structure View in InterPro
B 12 - 78 Show 3D Structure View in InterPro
1HUZ A 12 - 78 Show 3D Structure View in InterPro
B 12 - 78 Show 3D Structure View in InterPro
2BPF A 12 - 78 Show 3D Structure View in InterPro
2BPG A 12 - 78 Show 3D Structure View in InterPro
B 12 - 78 Show 3D Structure View in InterPro
3UXN A 12 - 78 Show 3D Structure View in InterPro
B 12 - 78 Show 3D Structure View in InterPro
3UXO A 12 - 78 Show 3D Structure View in InterPro
B 12 - 78 Show 3D Structure View in InterPro
3UXP A 12 - 78 Show 3D Structure View in InterPro
B 12 - 78 Show 3D Structure View in InterPro
3V72 A 12 - 78 Show 3D Structure View in InterPro
3V7J A 12 - 78 Show 3D Structure View in InterPro
3V7K A 12 - 78 Show 3D Structure View in InterPro
3V7L A 12 - 78 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;