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20  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MYB_MOUSE (P06876)

Summary

This is the summary of UniProt entry MYB_MOUSE (P06876).

Description: Transcriptional activator Myb
Source organism: Mus musculus (Mouse) (NCBI taxonomy ID 10090)
Length: 636 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 14
low_complexity n/a 7 27
disorder n/a 21 24
disorder n/a 37 42
Pfam Myb_DNA-binding 40 86
disorder n/a 49 51
Pfam Myb_DNA-binding 92 138
disorder n/a 129 130
disorder n/a 133 135
disorder n/a 137 143
Pfam Myb_DNA-binding 144 189
disorder n/a 180 187
disorder n/a 191 239
low_complexity n/a 227 239
Pfam LMSTEN 267 313
disorder n/a 276 303
low_complexity n/a 290 302
coiled_coil n/a 295 315
disorder n/a 306 321
disorder n/a 326 336
disorder n/a 338 371
disorder n/a 374 375
Pfam Cmyb_C 397 552
disorder n/a 409 434
disorder n/a 436 444
disorder n/a 449 454
disorder n/a 456 459
disorder n/a 462 463
disorder n/a 467 469
disorder n/a 481 486
disorder n/a 488 499
disorder n/a 502 511
disorder n/a 513 514
disorder n/a 518 526
disorder n/a 534 535
disorder n/a 566 570
disorder n/a 580 582
disorder n/a 596 597
disorder n/a 604 617
disorder n/a 620 622

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P06876. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MARRPRHSIY SSDEDDEDIE MCDHDYDGLL PKSGKRHLGK TRWTREEDEK
50
51
LKKLVEQNGT DDWKVIANYL PNRTDVQCQH RWQKVLNPEL IKGPWTKEED
100
101
QRVIELVQKY GPKRWSVIAK HLKGRIGKQC RERWHNHLNP EVKKTSWTEE
150
151
EDRIIYQAHK RLGNRWAEIA KLLPGRTDNA IKNHWNSTMR RKVEQEGYLQ
200
201
EPSKASQTPV ATSFQKNNHL MGFGHASPPS QLSPSGQSSV NSEYPYYHIA
250
251
EAQNISSHVP YPVALHVNIV NVPQPAAAAI QRHYNDEDPE KEKRIKELEL
300
301
LLMSTENELK GQQALPTQNH TCSYPGWHST SIVDQTRPHG DSAPVSCLGE
350
351
HHATPSLPAD PGSLPEESAS PARCMIVHQG TILDNVKNLL EFAETLQFID
400
401
SFLNTSSNHE SSGLDAPTLP STPLIGHKLT PCRDQTVKTQ KENSIFRTPA
450
451
IKRSILESSP RTPTPFKHAL AAQEIKYGPL KMLPQTPSHA VEDLQDVIKQ
500
501
ESDESGIVAE FQESGPPLLK KIKQEVESPT EKSGNFFCSN HWAENSLSTQ
550
551
LFSQASPVAD APNILTSSVL MTPVSEDEDN VLKAFTVPKN RPLVGPLQPC
600
601
SGAWEPASCG KTEDQMTASG PARKYVNAFS ARTLVM               
636
 

Show the unformatted sequence.

Checksums:
CRC64:0C6308E584726D01
MD5:466594274054348677a48e6652ca2907

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
LMSTEN 286 - 309 6DMX A 286 - 309 Show 3D Structure View in InterPro
287 - 309 6DMX H 287 - 309 Show 3D Structure View in InterPro
287 - 311 6DNQ A 287 - 311 Show 3D Structure View in InterPro
287 - 312 6DNQ C 287 - 312 Show 3D Structure View in InterPro
288 - 309 6DMX F 288 - 309 Show 3D Structure View in InterPro
288 - 312 6DMX C 288 - 312 Show 3D Structure View in InterPro
291 - 313 1SB0 B 88 - 110 Show 3D Structure View in InterPro
2AGH A 291 - 313 Show 3D Structure View in InterPro
Myb_DNA-binding 144 - 189 1GV2 A 144 - 189 Show 3D Structure View in InterPro
1H88 C 144 - 189 Show 3D Structure View in InterPro
1H89 C 144 - 189 Show 3D Structure View in InterPro
1IDY A 144 - 189 Show 3D Structure View in InterPro
1IDZ A 144 - 189 Show 3D Structure View in InterPro
1MBJ A 144 - 189 Show 3D Structure View in InterPro
1MBK A 144 - 189 Show 3D Structure View in InterPro
1MSE C 144 - 189 Show 3D Structure View in InterPro
1MSF C 144 - 189 Show 3D Structure View in InterPro
40 - 86 1GUU A 40 - 86 Show 3D Structure View in InterPro
1H88 C 40 - 86 Show 3D Structure View in InterPro
1MBE A 40 - 86 Show 3D Structure View in InterPro
1MBF A 40 - 86 Show 3D Structure View in InterPro
77 - 86 1H89 C 77 - 86 Show 3D Structure View in InterPro
92 - 138 1GV2 A 92 - 138 Show 3D Structure View in InterPro
1GV5 A 92 - 138 Show 3D Structure View in InterPro
1GVD A 92 - 138 Show 3D Structure View in InterPro
1H88 C 92 - 138 Show 3D Structure View in InterPro
1H89 C 92 - 138 Show 3D Structure View in InterPro
1MBG A 92 - 138 Show 3D Structure View in InterPro
1MBH A 92 - 138 Show 3D Structure View in InterPro
1MSE C 92 - 138 Show 3D Structure View in InterPro
1MSF C 92 - 138 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;