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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: LDHB_HUMAN (P07195)

Summary

This is the summary of UniProt entry LDHB_HUMAN (P07195).

Description: L-lactate dehydrogenase B chain EC=1.1.1.27
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 334 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam Ldh_1_N 22 161
Pfam Ldh_1_C 164 334
disorder n/a 221 223
disorder n/a 226 227

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P07195. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MATLKEKLIA PVAEEEATVP NNKITVVGVG QVGMACAISI LGKSLADELA
50
51
LVDVLEDKLK GEMMDLQHGS LFLQTPKIVA DKDYSVTANS KIVVVTAGVR
100
101
QQEGESRLNL VQRNVNVFKF IIPQIVKYSP DCIIIVVSNP VDILTYVTWK
150
151
LSGLPKHRVI GSGCNLDSAR FRYLMAEKLG IHPSSCHGWI LGEHGDSSVA
200
201
VWSGVNVAGV SLQELNPEMG TDNDSENWKE VHKMVVESAY EVIKLKGYTN
250
251
WAIGLSVADL IESMLKNLSR IHPVSTMVKG MYGIENEVFL SLPCILNARG
300
301
LTSVINQKLK DDEVAQLKKS ADTLWDIQKD LKDL                 
334
 

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Checksums:
CRC64:3AD605DEED0D54A2
MD5:d9540ad028613c151daa3eeb44683c48

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Ldh_1_C 164 - 333 1I0Z A 163 - 332 Jmol OpenAstexViewer
B 163 - 332 Jmol OpenAstexViewer
1T2F A 163 - 332 Jmol OpenAstexViewer
B 163 - 332 Jmol OpenAstexViewer
C 163 - 332 Jmol OpenAstexViewer
D 163 - 332 Jmol OpenAstexViewer
Ldh_1_N 22 - 161 1I0Z A 21 - 160 Jmol OpenAstexViewer
B 21 - 160 Jmol OpenAstexViewer
1T2F A 21 - 160 Jmol OpenAstexViewer
B 21 - 160 Jmol OpenAstexViewer
C 21 - 160 Jmol OpenAstexViewer
D 21 - 160 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.