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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: KLK3_HUMAN (P07288)

Summary

This is the summary of UniProt entry KLK3_HUMAN (P07288).

Description: Prostate-specific antigen EC=3.4.21.77
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 261 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 23
Pfam Trypsin 25 253

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P07288. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MWVPVVFLTL SVTWIGAAPL ILSRIVGGWE CEKHSQPWQV LVASRGRAVC
50
51
GGVLVHPQWV LTAAHCIRNK SVILLGRHSL FHPEDTGQVF QVSHSFPHPL
100
101
YDMSLLKNRF LRPGDDSSHD LMLLRLSEPA ELTDAVKVMD LPTQEPALGT
150
151
TCYASGWGSI EPEEFLTPKK LQCVDLHVIS NDVCAQVHPQ KVTKFMLCAG
200
201
RWTGGKSTCS GDSGGPLVCN GVLQGITSWG SEPCALPERP SLYTKVVHYR
250
251
KWIKDTIVAN P                                          
261
 

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Checksums:
CRC64:AE9E732AF872141A
MD5:7b20fc0d7d1b1ec9775485298b972518

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Trypsin 25 - 253 2ZCH P 16 - 238 Jmol OpenAstexViewer
2ZCK P 16 - 239 Jmol OpenAstexViewer
2ZCL P 16 - 238 Jmol OpenAstexViewer
3QUM P 16 - 238 Jmol OpenAstexViewer
Q 16 - 238 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.