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5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TRY1_HUMAN (P07477)

Summary

This is the summary of UniProt entry TRY1_HUMAN (P07477).

Description: Trypsin-1 EC=3.4.21.4
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 247 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 15
low_complexity n/a 10 21
Pfam Trypsin 24 239

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P07477. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MNPLLILTFV AAALAAPFDD DDKIVGGYNC EENSVPYQVS LNSGYHFCGG
50
51
SLINEQWVVS AGHCYKSRIQ VRLGEHNIEV LEGNEQFINA AKIIRHPQYD
100
101
RKTLNNDIML IKLSSRAVIN ARVSTISLPT APPATGTKCL ISGWGNTASS
150
151
GADYPDELQC LDAPVLSQAK CEASYPGKIT SNMFCVGFLE GGKDSCQGDS
200
201
GGPVVCNGQL QGVVSWGDGC AQKNKPGVYT KVYNYVKWIK NTIAANS   
247
 

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Checksums:
CRC64:DD49A487B8062813
MD5:b90d5b9f8f1791a5afe546560ecd79bf

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Trypsin 24 - 239 1FXY A 16 - 238 Jmol OpenAstexViewer
1TRN A 16 - 238 Jmol OpenAstexViewer
B 16 - 238 Jmol OpenAstexViewer
2RA3 A 16 - 238 Jmol OpenAstexViewer
B 16 - 238 Jmol OpenAstexViewer
4WWY A 16 - 238 Jmol OpenAstexViewer
B 16 - 238 Jmol OpenAstexViewer
4WXV A 16 - 238 Jmol OpenAstexViewer
B 16 - 238 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.