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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: TYRR_ECOLI (P07604)

Summary

This is the summary of UniProt entry TYRR_ECOLI (P07604).

Description: Transcriptional regulatory protein TyrR
Source organism: Escherichia coli (strain K12) (NCBI taxonomy ID 83333)
Length: 513 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
low_complexity n/a 9 30
low_complexity n/a 80 96
Pfam PAS_8 81 145
Pfam Sigma54_activat 206 366
Pfam HTH_50 458 507
disorder n/a 508 513

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P07604. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MRLEVFCEDR LGLTRELLDL LVLRGIDLRG IEIDPIGRIY LNFAELEFES
50
51
FSSLMAEIRR IAGVTDVRTV PWMPSEREHL ALSALLEALP EPVLSVDMKS
100
101
KVDMANPASC QLFGQKLDRL RNHTAAQLIN GFNFLRWLES EPQDSHNEHV
150
151
VINGQNFLME ITPVYLQDEN DQHVLTGAVV MLRSTIRMGR QLQNVAAQDV
200
201
SAFSQIVAVS PKMKHVVEQA QKLAMLSAPL LITGDTGTGK DLFAYACHQA
250
251
SPRAGKPYLA LNCASIPEDA VESELFGHAP EGKKGFFEQA NGGSVLLDEI
300
301
GEMSPRMQAK LLRFLNDGTF RRVGEDHEVH VDVRVICATQ KNLVELVQKG
350
351
MFREDLYYRL NVLTLNLPPL RDCPQDIMPL TELFVARFAD EQGVPRPKLA
400
401
ADLNTVLTRY AWPGNVRQLK NAIYRALTQL DGYELRPQDI LLPDYDAATV
450
451
AVGEDAMEGS LDEITSRFER SVLTQLYRNY PSTRKLAKRL GVSHTAIANK
500
501
LREYGLSQKK NEE                                        
513
 

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Checksums:
CRC64:B580A401C3A27866
MD5:2d30e9c6a468d54a6af5c09e8e9ff6b1

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
PAS_8 81 - 145 2JHE A 81 - 145 Show 3D Structure View in InterPro
B 81 - 145 Show 3D Structure View in InterPro
C 81 - 145 Show 3D Structure View in InterPro
D 81 - 145 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;