Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TRUA_ECOLI (P07649)

Summary

This is the summary of UniProt entry TRUA_ECOLI (P07649).

Description: tRNA pseudouridine synthase A EC=5.4.99.12
Source organism: Escherichia coli (strain K12) (NCBI taxonomy ID 83333)
Length: 270 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
Pfam PseudoU_synth_1 15 112
Pfam PseudoU_synth_1 151 253
low_complexity n/a 227 242

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P07649. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSDQQQPPVY KIALGIEYDG SKYYGWQRQN EVRSVQEKLE KALSQVANEP
50
51
ITVFCAGRTD AGVHGTGQVV HFETTALRKD AAWTLGVNAN LPGDIAVRWV
100
101
KTVPDDFHAR FSATARRYRY IIYNHRLRPA VLSKGVTHFY EPLDAERMHR
150
151
AAQCLLGEND FTSFRAVQCQ SRTPWRNVMH INVTRHGPYV VVDIKANAFV
200
201
HHMVRNIVGS LMEVGAHNQP ESWIAELLAA KDRTLAAATA KAEGLYLVAV
250
251
DYPDRYDLPK PPMGPLFLAD                                 
270
 

Show the unformatted sequence.

Checksums:
CRC64:8E97BC88C3220188
MD5:eff7bcacb9fe4119018b295d02e209c9

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
PseudoU_synth_1 15 - 112 1DJ0 A 15 - 112 Show 3D Structure View in InterPro
B 15 - 112 Show 3D Structure View in InterPro
2NQP A 15 - 112 Show 3D Structure View in InterPro
B 15 - 112 Show 3D Structure View in InterPro
C 15 - 112 Show 3D Structure View in InterPro
D 15 - 112 Show 3D Structure View in InterPro
2NR0 A 15 - 112 Show 3D Structure View in InterPro
B 15 - 112 Show 3D Structure View in InterPro
C 15 - 112 Show 3D Structure View in InterPro
D 15 - 112 Show 3D Structure View in InterPro
2NRE A 15 - 112 Show 3D Structure View in InterPro
151 - 253 1DJ0 A 151 - 253 Show 3D Structure View in InterPro
B 151 - 253 Show 3D Structure View in InterPro
2NQP A 151 - 253 Show 3D Structure View in InterPro
B 151 - 253 Show 3D Structure View in InterPro
C 151 - 253 Show 3D Structure View in InterPro
D 151 - 253 Show 3D Structure View in InterPro
2NR0 A 151 - 253 Show 3D Structure View in InterPro
B 151 - 253 Show 3D Structure View in InterPro
C 151 - 253 Show 3D Structure View in InterPro
D 151 - 253 Show 3D Structure View in InterPro
2NRE A 151 - 253 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;