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14  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CATB_HUMAN (P07858)

Summary

This is the summary of UniProt entry CATB_HUMAN (P07858).

Description: Cathepsin B EC=3.4.22.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 339 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 19
Pfam Propeptide_C1 26 65
Pfam Peptidase_C1 80 329

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P07858. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MWQLWASLCC LLVLANARSR PSFHPLSDEL VNYVNKRNTT WQAGHNFYNV
50
51
DMSYLKRLCG TFLGGPKPPQ RVMFTEDLKL PASFDAREQW PQCPTIKEIR
100
101
DQGSCGSCWA FGAVEAISDR ICIHTNAHVS VEVSAEDLLT CCGSMCGDGC
150
151
NGGYPAEAWN FWTRKGLVSG GLYESHVGCR PYSIPPCEHH VNGSRPPCTG
200
201
EGDTPKCSKI CEPGYSPTYK QDKHYGYNSY SVSNSEKDIM AEIYKNGPVE
250
251
GAFSVYSDFL LYKSGVYQHV TGEMMGGHAI RILGWGVENG TPYWLVANSW
300
301
NTDWGDNGFF KILRGQDHCG IESEVVAGIP RTDQYWEKI            
339
 

Show the unformatted sequence.

Checksums:
CRC64:0FC818EA4C1F6D90
MD5:6846be2036cf0fbe2910b3de38f5c6f2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Peptidase_C1 129 - 329 1CSB B 50 - 250 Jmol OpenAstexViewer
E 50 - 250 Jmol OpenAstexViewer
1HUC B 50 - 250 Jmol OpenAstexViewer
D 50 - 250 Jmol OpenAstexViewer
2IPP B 50 - 250 Jmol OpenAstexViewer
80 - 126 1CSB A 1 - 47 Jmol OpenAstexViewer
D 1 - 47 Jmol OpenAstexViewer
1HUC A 1 - 47 Jmol OpenAstexViewer
C 1 - 47 Jmol OpenAstexViewer
2IPP A 1 - 47 Jmol OpenAstexViewer
80 - 329 1GMY A 1 - 250 Jmol OpenAstexViewer
B 1 - 250 Jmol OpenAstexViewer
C 1 - 250 Jmol OpenAstexViewer
1PBH A 1 - 250 Jmol OpenAstexViewer
2PBH A 1 - 250 Jmol OpenAstexViewer
3AI8 A 1 - 250 Jmol OpenAstexViewer
B 1 - 250 Jmol OpenAstexViewer
3CBJ A 1 - 250 Jmol OpenAstexViewer
3CBK A 1 - 250 Jmol OpenAstexViewer
3K9M A 1 - 250 Jmol OpenAstexViewer
B 1 - 250 Jmol OpenAstexViewer
3PBH A 1 - 250 Jmol OpenAstexViewer
5MBL A 2 - 251 Jmol OpenAstexViewer
5MBM A 1 - 250 Jmol OpenAstexViewer
B 1 - 250 Jmol OpenAstexViewer
6AY2 A 1 - 250 Jmol OpenAstexViewer
B 1 - 250 Jmol OpenAstexViewer
Propeptide_C1 26 - 65 1PBH A 9 - 48 Jmol OpenAstexViewer
2PBH A 9 - 48 Jmol OpenAstexViewer
3PBH A 9 - 48 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.