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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TSP1_HUMAN (P07996)

Summary

This is the summary of UniProt entry TSP1_HUMAN (P07996).

Description: Thrombospondin-1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 1170 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 18
disorder n/a 45 49
disorder n/a 51 54
disorder n/a 60 63
coiled_coil n/a 291 311
disorder n/a 305 306
Pfam VWC 318 372
Pfam TSP_1 383 428
Pfam TSP_1 439 489
Pfam TSP_1 496 546
disorder n/a 631 632
disorder n/a 724 726
Pfam TSP_3 727 762
low_complexity n/a 727 753
disorder n/a 729 742
disorder n/a 749 753
Pfam TSP_3 762 785
low_complexity n/a 762 774
disorder n/a 776 801
Pfam TSP_3 786 821
low_complexity n/a 791 804
disorder n/a 810 821
Pfam TSP_3 821 844
disorder n/a 826 934
Pfam TSP_3 845 882
low_complexity n/a 882 900
Pfam TSP_3 883 918
low_complexity n/a 894 907
Pfam TSP_3 919 954
disorder n/a 937 938
disorder n/a 941 948
disorder n/a 957 958
disorder n/a 961 980
Pfam TSP_C 972 1169
disorder n/a 982 984
disorder n/a 1076 1081

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P07996. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGLAWGLGVL FLMHVCGTNR IPESGGDNSV FDIFELTGAA RKGSGRRLVK
50
51
GPDPSSPAFR IEDANLIPPV PDDKFQDLVD AVRAEKGFLL LASLRQMKKT
100
101
RGTLLALERK DHSGQVFSVV SNGKAGTLDL SLTVQGKQHV VSVEEALLAT
150
151
GQWKSITLFV QEDRAQLYID CEKMENAELD VPIQSVFTRD LASIARLRIA
200
201
KGGVNDNFQG VLQNVRFVFG TTPEDILRNK GCSSSTSVLL TLDNNVVNGS
250
251
SPAIRTNYIG HKTKDLQAIC GISCDELSSM VLELRGLRTI VTTLQDSIRK
300
301
VTEENKELAN ELRRPPLCYH NGVQYRNNEE WTVDSCTECH CQNSVTICKK
350
351
VSCPIMPCSN ATVPDGECCP RCWPSDSADD GWSPWSEWTS CSTSCGNGIQ
400
401
QRGRSCDSLN NRCEGSSVQT RTCHIQECDK RFKQDGGWSH WSPWSSCSVT
450
451
CGDGVITRIR LCNSPSPQMN GKPCEGEARE TKACKKDACP INGGWGPWSP
500
501
WDICSVTCGG GVQKRSRLCN NPTPQFGGKD CVGDVTENQI CNKQDCPIDG
550
551
CLSNPCFAGV KCTSYPDGSW KCGACPPGYS GNGIQCTDVD ECKEVPDACF
600
601
NHNGEHRCEN TDPGYNCLPC PPRFTGSQPF GQGVEHATAN KQVCKPRNPC
650
651
TDGTHDCNKN AKCNYLGHYS DPMYRCECKP GYAGNGIICG EDTDLDGWPN
700
701
ENLVCVANAT YHCKKDNCPN LPNSGQEDYD KDGIGDACDD DDDNDKIPDD
750
751
RDNCPFHYNP AQYDYDRDDV GDRCDNCPYN HNPDQADTDN NGEGDACAAD
800
801
IDGDGILNER DNCQYVYNVD QRDTDMDGVG DQCDNCPLEH NPDQLDSDSD
850
851
RIGDTCDNNQ DIDEDGHQNN LDNCPYVPNA NQADHDKDGK GDACDHDDDN
900
901
DGIPDDKDNC RLVPNPDQKD SDGDGRGDAC KDDFDHDSVP DIDDICPENV
950
951
DISETDFRRF QMIPLDPKGT SQNDPNWVVR HQGKELVQTV NCDPGLAVGY
1000
1001
DEFNAVDFSG TFFINTERDD DYAGFVFGYQ SSSRFYVVMW KQVTQSYWDT
1050
1051
NPTRAQGYSG LSVKVVNSTT GPGEHLRNAL WHTGNTPGQV RTLWHDPRHI
1100
1101
GWKDFTAYRW RLSHRPKTGF IRVVMYEGKK IMADSGPIYD KTYAGGRLGL
1150
1151
FVFSQEMVFF SDLKYECRDP                                 
1170
 

Show the unformatted sequence.

Checksums:
CRC64:74749B2418E0943B
MD5:6b632ebf73d88f74004685ef94f5cf9b

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
TSP_1 383 - 428 5FOE A 1006 - 1051 Jmol OpenAstexViewer
B 1006 - 1051 Jmol OpenAstexViewer
439 - 489 1LSL A 421 - 471 Jmol OpenAstexViewer
3R6B A 439 - 489 Jmol OpenAstexViewer
496 - 546 1LSL A 478 - 528 Jmol OpenAstexViewer
3R6B A 496 - 546 Jmol OpenAstexViewer
TSP_3 834 - 844 1UX6 A 816 - 826 Jmol OpenAstexViewer
845 - 882 1UX6 A 827 - 864 Jmol OpenAstexViewer
883 - 918 1UX6 A 865 - 900 Jmol OpenAstexViewer
919 - 954 1UX6 A 901 - 936 Jmol OpenAstexViewer
TSP_C 972 - 1169 1UX6 A 954 - 1151 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.