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29  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: IGF1R_HUMAN (P08069)

Summary

This is the summary of UniProt entry IGF1R_HUMAN (P08069).

Description: Insulin-like growth factor 1 receptor EC=2.7.10.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1367 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 30
Pfam Recep_L_domain 51 161
Pfam Furin-like 175 333
Pfam Recep_L_domain 352 466
low_complexity n/a 358 370
disorder n/a 470 482
disorder n/a 684 687
disorder n/a 703 706
coiled_coil n/a 704 724
low_complexity n/a 704 717
disorder n/a 737 766
low_complexity n/a 746 760
disorder n/a 774 778
disorder n/a 832 838
transmembrane n/a 933 958
low_complexity n/a 934 957
Pfam PK_Tyr_Ser-Thr 999 1266
low_complexity n/a 1283 1301
disorder n/a 1288 1341
low_complexity n/a 1302 1317
disorder n/a 1344 1367

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P08069. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MKSGSGGGSP TSLWGLLFLS AALSLWPTSG EICGPGIDIR NDYQQLKRLE
50
51
NCTVIEGYLH ILLISKAEDY RSYRFPKLTV ITEYLLLFRV AGLESLGDLF
100
101
PNLTVIRGWK LFYNYALVIF EMTNLKDIGL YNLRNITRGA IRIEKNADLC
150
151
YLSTVDWSLI LDAVSNNYIV GNKPPKECGD LCPGTMEEKP MCEKTTINNE
200
201
YNYRCWTTNR CQKMCPSTCG KRACTENNEC CHPECLGSCS APDNDTACVA
250
251
CRHYYYAGVC VPACPPNTYR FEGWRCVDRD FCANILSAES SDSEGFVIHD
300
301
GECMQECPSG FIRNGSQSMY CIPCEGPCPK VCEEEKKTKT IDSVTSAQML
350
351
QGCTIFKGNL LINIRRGNNI ASELENFMGL IEVVTGYVKI RHSHALVSLS
400
401
FLKNLRLILG EEQLEGNYSF YVLDNQNLQQ LWDWDHRNLT IKAGKMYFAF
450
451
NPKLCVSEIY RMEEVTGTKG RQSKGDINTR NNGERASCES DVLHFTSTTT
500
501
SKNRIIITWH RYRPPDYRDL ISFTVYYKEA PFKNVTEYDG QDACGSNSWN
550
551
MVDVDLPPNK DVEPGILLHG LKPWTQYAVY VKAVTLTMVE NDHIRGAKSE
600
601
ILYIRTNASV PSIPLDVLSA SNSSSQLIVK WNPPSLPNGN LSYYIVRWQR
650
651
QPQDGYLYRH NYCSKDKIPI RKYADGTIDI EEVTENPKTE VCGGEKGPCC
700
701
ACPKTEAEKQ AEKEEAEYRK VFENFLHNSI FVPRPERKRR DVMQVANTTM
750
751
SSRSRNTTAA DTYNITDPEE LETEYPFFES RVDNKERTVI SNLRPFTLYR
800
801
IDIHSCNHEA EKLGCSASNF VFARTMPAEG ADDIPGPVTW EPRPENSIFL
850
851
KWPEPENPNG LILMYEIKYG SQVEDQRECV SRQEYRKYGG AKLNRLNPGN
900
901
YTARIQATSL SGNGSWTDPV FFYVQAKTGY ENFIHLIIAL PVAVLLIVGG
950
951
LVIMLYVFHR KRNNSRLGNG VLYASVNPEY FSAADVYVPD EWEVAREKIT
1000
1001
MSRELGQGSF GMVYEGVAKG VVKDEPETRV AIKTVNEAAS MRERIEFLNE
1050
1051
ASVMKEFNCH HVVRLLGVVS QGQPTLVIME LMTRGDLKSY LRSLRPEMEN
1100
1101
NPVLAPPSLS KMIQMAGEIA DGMAYLNANK FVHRDLAARN CMVAEDFTVK
1150
1151
IGDFGMTRDI YETDYYRKGG KGLLPVRWMS PESLKDGVFT TYSDVWSFGV
1200
1201
VLWEIATLAE QPYQGLSNEQ VLRFVMEGGL LDKPDNCPDM LFELMRMCWQ
1250
1251
YNPKMRPSFL EIISSIKEEM EPGFREVSFY YSEENKLPEP EELDLEPENM
1300
1301
ESVPLDPSAS SSSLPLPDRH SGHKAENGPG PGVLVLRASF DERQPYAHMN
1350
1351
GGRKNERALP LPQSSTC                                    
1367
 

Show the unformatted sequence.

Checksums:
CRC64:AE8A735F87F745C8
MD5:7319b21e0d5b3e8342fa71c29192f156

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Furin-like 175 - 330 6VWH B 145 - 300 Show 3D Structure View in InterPro
6VWJ B 145 - 300 Show 3D Structure View in InterPro
175 - 333 1IGR A 145 - 303 Show 3D Structure View in InterPro
5U8Q A 145 - 303 Show 3D Structure View in InterPro
5U8R A 145 - 303 Show 3D Structure View in InterPro
6JK8 A 175 - 333 Show 3D Structure View in InterPro
B 175 - 333 Show 3D Structure View in InterPro
6VWG A 145 - 303 Show 3D Structure View in InterPro
6VWI A 145 - 303 Show 3D Structure View in InterPro
329 - 333 6VWG B 299 - 303 Show 3D Structure View in InterPro
6VWI B 299 - 303 Show 3D Structure View in InterPro
PK_Tyr_Ser-Thr 999 - 1266 1JQH A 999 - 1266 Show 3D Structure View in InterPro
B 999 - 1266 Show 3D Structure View in InterPro
C 999 - 1266 Show 3D Structure View in InterPro
1K3A A 969 - 1236 Show 3D Structure View in InterPro
1M7N A 996 - 1263 Show 3D Structure View in InterPro
B 996 - 1263 Show 3D Structure View in InterPro
1P4O A 969 - 1236 Show 3D Structure View in InterPro
B 969 - 1236 Show 3D Structure View in InterPro
2OJ9 A 969 - 1236 Show 3D Structure View in InterPro
2ZM3 A 999 - 1266 Show 3D Structure View in InterPro
B 999 - 1266 Show 3D Structure View in InterPro
C 999 - 1266 Show 3D Structure View in InterPro
D 999 - 1266 Show 3D Structure View in InterPro
3D94 A 969 - 1236 Show 3D Structure View in InterPro
3F5P A 999 - 1266 Show 3D Structure View in InterPro
B 999 - 1266 Show 3D Structure View in InterPro
C 999 - 1266 Show 3D Structure View in InterPro
D 999 - 1266 Show 3D Structure View in InterPro
E 999 - 1266 Show 3D Structure View in InterPro
F 999 - 1266 Show 3D Structure View in InterPro
G 999 - 1266 Show 3D Structure View in InterPro
H 999 - 1266 Show 3D Structure View in InterPro
I 999 - 1266 Show 3D Structure View in InterPro
J 999 - 1266 Show 3D Structure View in InterPro
K 999 - 1266 Show 3D Structure View in InterPro
L 999 - 1266 Show 3D Structure View in InterPro
M 999 - 1266 Show 3D Structure View in InterPro
R 999 - 1266 Show 3D Structure View in InterPro
S 999 - 1266 Show 3D Structure View in InterPro
T 999 - 1266 Show 3D Structure View in InterPro
3I81 A 969 - 1236 Show 3D Structure View in InterPro
3LVP A 999 - 1266 Show 3D Structure View in InterPro
B 999 - 1266 Show 3D Structure View in InterPro
C 999 - 1266 Show 3D Structure View in InterPro
D 999 - 1266 Show 3D Structure View in InterPro
3LW0 A 999 - 1266 Show 3D Structure View in InterPro
B 999 - 1266 Show 3D Structure View in InterPro
C 999 - 1266 Show 3D Structure View in InterPro
D 999 - 1266 Show 3D Structure View in InterPro
3NW5 A 969 - 1236 Show 3D Structure View in InterPro
3NW6 A 969 - 1236 Show 3D Structure View in InterPro
3NW7 A 969 - 1236 Show 3D Structure View in InterPro
3O23 A 999 - 1266 Show 3D Structure View in InterPro
3QQU A 996 - 1263 Show 3D Structure View in InterPro
B 996 - 1263 Show 3D Structure View in InterPro
C 996 - 1263 Show 3D Structure View in InterPro
D 996 - 1263 Show 3D Structure View in InterPro
4D2R A 999 - 1266 Show 3D Structure View in InterPro
5FXQ A 999 - 1266 Show 3D Structure View in InterPro
5FXR A 999 - 1266 Show 3D Structure View in InterPro
5FXS A 999 - 1266 Show 3D Structure View in InterPro
5HZN A 996 - 1263 Show 3D Structure View in InterPro
B 996 - 1263 Show 3D Structure View in InterPro
C 996 - 1263 Show 3D Structure View in InterPro
D 996 - 1263 Show 3D Structure View in InterPro
E 996 - 1263 Show 3D Structure View in InterPro
F 996 - 1263 Show 3D Structure View in InterPro
G 996 - 1263 Show 3D Structure View in InterPro
H 996 - 1263 Show 3D Structure View in InterPro
Recep_L_domain 352 - 466 1IGR A 322 - 436 Show 3D Structure View in InterPro
5U8Q A 322 - 436 Show 3D Structure View in InterPro
5U8R A 322 - 436 Show 3D Structure View in InterPro
6JK8 A 352 - 466 Show 3D Structure View in InterPro
B 352 - 466 Show 3D Structure View in InterPro
6VWG A 322 - 436 Show 3D Structure View in InterPro
B 322 - 436 Show 3D Structure View in InterPro
6VWI A 322 - 436 Show 3D Structure View in InterPro
B 322 - 436 Show 3D Structure View in InterPro
51 - 161 1IGR A 21 - 131 Show 3D Structure View in InterPro
5U8Q A 21 - 131 Show 3D Structure View in InterPro
5U8R A 21 - 131 Show 3D Structure View in InterPro
6JK8 A 51 - 161 Show 3D Structure View in InterPro
B 51 - 161 Show 3D Structure View in InterPro
6VWG A 21 - 131 Show 3D Structure View in InterPro
6VWH B 21 - 131 Show 3D Structure View in InterPro
6VWI A 21 - 131 Show 3D Structure View in InterPro
6VWJ B 21 - 131 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;