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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: OPSD_HUMAN (P08100)

Summary

This is the summary of UniProt entry OPSD_HUMAN (P08100).

Description: Rhodopsin
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 348 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam Rhodopsin_N 2 37
transmembrane n/a 40 63
Pfam 7tm_1 54 306
transmembrane n/a 75 95
transmembrane n/a 115 133
transmembrane n/a 153 173
transmembrane n/a 203 223
low_complexity n/a 230 246
transmembrane n/a 254 277
transmembrane n/a 283 308
disorder n/a 333 334

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P08100. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MNGTEGPNFY VPFSNATGVV RSPFEYPQYY LAEPWQFSML AAYMFLLIVL
50
51
GFPINFLTLY VTVQHKKLRT PLNYILLNLA VADLFMVLGG FTSTLYTSLH
100
101
GYFVFGPTGC NLEGFFATLG GEIALWSLVV LAIERYVVVC KPMSNFRFGE
150
151
NHAIMGVAFT WVMALACAAP PLAGWSRYIP EGLQCSCGID YYTLKPEVNN
200
201
ESFVIYMFVV HFTIPMIIIF FCYGQLVFTV KEAAAQQQES ATTQKAEKEV
250
251
TRMVIIMVIA FLICWVPYAS VAFYIFTHQG SNFGPIFMTI PAFFAKSAAI
300
301
YNPVIYIMMN KQFRNCMLTT ICCGKNPLGD DEASATVSKT ETSQVAPA  
348
 

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Checksums:
CRC64:6F4F6FCBA34265B2
MD5:d000022e87e6b7b84cccba9baf34568a

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
7tm_1 54 - 306 4ZWJ A 54 - 306 Jmol OpenAstexViewer
B 54 - 306 Jmol OpenAstexViewer
C 54 - 306 Jmol OpenAstexViewer
D 54 - 306 Jmol OpenAstexViewer
5DGY A 54 - 306 Jmol OpenAstexViewer
B 54 - 306 Jmol OpenAstexViewer
C 54 - 306 Jmol OpenAstexViewer
D 54 - 306 Jmol OpenAstexViewer
5W0P A 54 - 306 Jmol OpenAstexViewer
B 54 - 306 Jmol OpenAstexViewer
C 54 - 306 Jmol OpenAstexViewer
D 54 - 306 Jmol OpenAstexViewer
6CMO R 54 - 306 Jmol OpenAstexViewer
Rhodopsin_N 2 - 37 4ZWJ A 2 - 37 Jmol OpenAstexViewer
B 2 - 37 Jmol OpenAstexViewer
C 2 - 37 Jmol OpenAstexViewer
D 2 - 37 Jmol OpenAstexViewer
5DGY A 2 - 37 Jmol OpenAstexViewer
B 2 - 37 Jmol OpenAstexViewer
C 2 - 37 Jmol OpenAstexViewer
D 2 - 37 Jmol OpenAstexViewer
5W0P A 2 - 37 Jmol OpenAstexViewer
B 2 - 37 Jmol OpenAstexViewer
C 2 - 37 Jmol OpenAstexViewer
D 2 - 37 Jmol OpenAstexViewer
3 - 37 6CMO R 3 - 37 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.