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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MDR1_HUMAN (P08183)

Summary

This is the summary of UniProt entry MDR1_HUMAN (P08183).

Description: Multidrug resistance protein 1 EC=3.6.3.44
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 1280 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 4
low_complexity n/a 11 21
low_complexity n/a 17 30
disorder n/a 21 22
transmembrane n/a 49 72
Pfam ABC_membrane 51 343
transmembrane n/a 115 139
transmembrane n/a 190 208
transmembrane n/a 214 233
coiled_coil n/a 267 287
transmembrane n/a 293 316
transmembrane n/a 328 346
Pfam ABC_tran 410 559
coiled_coil n/a 634 654
disorder n/a 636 639
disorder n/a 648 650
disorder n/a 664 665
disorder n/a 674 676
transmembrane n/a 708 733
Pfam ABC_membrane 711 986
low_complexity n/a 751 767
transmembrane n/a 753 777
transmembrane n/a 833 853
low_complexity n/a 858 873
transmembrane n/a 859 879
transmembrane n/a 935 954
transmembrane n/a 974 995
Pfam ABC_tran 1053 1204
disorder n/a 1169 1172

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P08183. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MDLEGDRNGG AKKKNFFKLN NKSEKDKKEK KPTVSVFSMF RYSNWLDKLY
50
51
MVVGTLAAII HGAGLPLMML VFGEMTDIFA NAGNLEDLMS NITNRSDIND
100
101
TGFFMNLEED MTRYAYYYSG IGAGVLVAAY IQVSFWCLAA GRQIHKIRKQ
150
151
FFHAIMRQEI GWFDVHDVGE LNTRLTDDVS KINEGIGDKI GMFFQSMATF
200
201
FTGFIVGFTR GWKLTLVILA ISPVLGLSAA VWAKILSSFT DKELLAYAKA
250
251
GAVAEEVLAA IRTVIAFGGQ KKELERYNKN LEEAKRIGIK KAITANISIG
300
301
AAFLLIYASY ALAFWYGTTL VLSGEYSIGQ VLTVFFSVLI GAFSVGQASP
350
351
SIEAFANARG AAYEIFKIID NKPSIDSYSK SGHKPDNIKG NLEFRNVHFS
400
401
YPSRKEVKIL KGLNLKVQSG QTVALVGNSG CGKSTTVQLM QRLYDPTEGM
450
451
VSVDGQDIRT INVRFLREII GVVSQEPVLF ATTIAENIRY GRENVTMDEI
500
501
EKAVKEANAY DFIMKLPHKF DTLVGERGAQ LSGGQKQRIA IARALVRNPK
550
551
ILLLDEATSA LDTESEAVVQ VALDKARKGR TTIVIAHRLS TVRNADVIAG
600
601
FDDGVIVEKG NHDELMKEKG IYFKLVTMQT AGNEVELENA ADESKSEIDA
650
651
LEMSSNDSRS SLIRKRSTRR SVRGSQAQDR KLSTKEALDE SIPPVSFWRI
700
701
MKLNLTEWPY FVVGVFCAII NGGLQPAFAI IFSKIIGVFT RIDDPETKRQ
750
751
NSNLFSLLFL ALGIISFITF FLQGFTFGKA GEILTKRLRY MVFRSMLRQD
800
801
VSWFDDPKNT TGALTTRLAN DAAQVKGAIG SRLAVITQNI ANLGTGIIIS
850
851
FIYGWQLTLL LLAIVPIIAI AGVVEMKMLS GQALKDKKEL EGSGKIATEA
900
901
IENFRTVVSL TQEQKFEHMY AQSLQVPYRN SLRKAHIFGI TFSFTQAMMY
950
951
FSYAGCFRFG AYLVAHKLMS FEDVLLVFSA VVFGAMAVGQ VSSFAPDYAK
1000
1001
AKISAAHIIM IIEKTPLIDS YSTEGLMPNT LEGNVTFGEV VFNYPTRPDI
1050
1051
PVLQGLSLEV KKGQTLALVG SSGCGKSTVV QLLERFYDPL AGKVLLDGKE
1100
1101
IKRLNVQWLR AHLGIVSQEP ILFDCSIAEN IAYGDNSRVV SQEEIVRAAK
1150
1151
EANIHAFIES LPNKYSTKVG DKGTQLSGGQ KQRIAIARAL VRQPHILLLD
1200
1201
EATSALDTES EKVVQEALDK AREGRTCIVI AHRLSTIQNA DLIVVFQNGR
1250
1251
VKEHGTHQQL LAQKGIYFSM VSVQAGTKRQ                      
1280
 

Show the unformatted sequence.

Checksums:
CRC64:F0230744AB288C73
MD5:e8c72a9371a2775313fe0714108c5e40

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
ABC_membrane 51 - 343 6C0V A 51 - 343 Jmol OpenAstexViewer
6FN1 A 50 - 342 Jmol OpenAstexViewer
6FN4 A 50 - 342 Jmol OpenAstexViewer
711 - 986 6C0V A 711 - 986 Jmol OpenAstexViewer
6FN1 A 710 - 985 Jmol OpenAstexViewer
6FN4 A 710 - 985 Jmol OpenAstexViewer
ABC_tran 1053 - 1204 6C0V A 1053 - 1204 Jmol OpenAstexViewer
6FN1 A 1052 - 1203 Jmol OpenAstexViewer
6FN4 A 1052 - 1203 Jmol OpenAstexViewer
410 - 559 6C0V A 410 - 559 Jmol OpenAstexViewer
6FN1 A 409 - 558 Jmol OpenAstexViewer
6FN4 A 409 - 558 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.