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13  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: HS90B_HUMAN (P08238)

Summary

This is the summary of UniProt entry HS90B_HUMAN (P08238).

Description: Heat shock protein HSP 90-beta
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 724 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 5
low_complexity n/a 3 13
disorder n/a 7 9
Pfam HATPase_c 35 189
disorder n/a 70 72
disorder n/a 157 163
disorder n/a 166 170
disorder n/a 178 180
Pfam HSP90 191 712
low_complexity n/a 220 252
disorder n/a 222 270
low_complexity n/a 250 275
disorder n/a 287 293
disorder n/a 453 454
disorder n/a 468 471
low_complexity n/a 538 561
disorder n/a 539 552
coiled_coil n/a 543 563
disorder n/a 622 623
disorder n/a 632 642
low_complexity n/a 691 707
disorder n/a 695 724

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P08238. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPEEVHHGEE EVETFAFQAE IAQLMSLIIN TFYSNKEIFL RELISNASDA
50
51
LDKIRYESLT DPSKLDSGKE LKIDIIPNPQ ERTLTLVDTG IGMTKADLIN
100
101
NLGTIAKSGT KAFMEALQAG ADISMIGQFG VGFYSAYLVA EKVVVITKHN
150
151
DDEQYAWESS AGGSFTVRAD HGEPIGRGTK VILHLKEDQT EYLEERRVKE
200
201
VVKKHSQFIG YPITLYLEKE REKEISDDEA EEEKGEKEEE DKDDEEKPKI
250
251
EDVGSDEEDD SGKDKKKKTK KIKEKYIDQE ELNKTKPIWT RNPDDITQEE
300
301
YGEFYKSLTN DWEDHLAVKH FSVEGQLEFR ALLFIPRRAP FDLFENKKKK
350
351
NNIKLYVRRV FIMDSCDELI PEYLNFIRGV VDSEDLPLNI SREMLQQSKI
400
401
LKVIRKNIVK KCLELFSELA EDKENYKKFY EAFSKNLKLG IHEDSTNRRR
450
451
LSELLRYHTS QSGDEMTSLS EYVSRMKETQ KSIYYITGES KEQVANSAFV
500
501
ERVRKRGFEV VYMTEPIDEY CVQQLKEFDG KSLVSVTKEG LELPEDEEEK
550
551
KKMEESKAKF ENLCKLMKEI LDKKVEKVTI SNRLVSSPCC IVTSTYGWTA
600
601
NMERIMKAQA LRDNSTMGYM MAKKHLEINP DHPIVETLRQ KAEADKNDKA
650
651
VKDLVVLLFE TALLSSGFSL EDPQTHSNRI YRMIKLGLGI DEDEVAAEEP
700
701
NAAVPDEIPP LEGDEDASRM EEVD                            
724
 

Show the unformatted sequence.

Checksums:
CRC64:A93118C214D03810
MD5:949f432ce31c866b10f2ad852c228ce0

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
HATPase_c 35 - 189 1UYM A 40 - 194 Show 3D Structure View in InterPro
3NMQ A 40 - 194 Show 3D Structure View in InterPro
5FWK A 35 - 189 Show 3D Structure View in InterPro
B 35 - 189 Show 3D Structure View in InterPro
5FWL A 35 - 189 Show 3D Structure View in InterPro
B 35 - 189 Show 3D Structure View in InterPro
5FWM A 35 - 189 Show 3D Structure View in InterPro
B 35 - 189 Show 3D Structure View in InterPro
5FWP A 35 - 189 Show 3D Structure View in InterPro
B 35 - 189 Show 3D Structure View in InterPro
5UC4 A 35 - 189 Show 3D Structure View in InterPro
B 35 - 189 Show 3D Structure View in InterPro
C 35 - 189 Show 3D Structure View in InterPro
D 35 - 189 Show 3D Structure View in InterPro
5UCH A 35 - 189 Show 3D Structure View in InterPro
B 35 - 189 Show 3D Structure View in InterPro
C 35 - 189 Show 3D Structure View in InterPro
D 35 - 189 Show 3D Structure View in InterPro
5UCI A 35 - 189 Show 3D Structure View in InterPro
B 35 - 189 Show 3D Structure View in InterPro
C 35 - 189 Show 3D Structure View in InterPro
D 35 - 189 Show 3D Structure View in InterPro
5UCJ A 35 - 189 Show 3D Structure View in InterPro
B 35 - 189 Show 3D Structure View in InterPro
C 35 - 189 Show 3D Structure View in InterPro
D 35 - 189 Show 3D Structure View in InterPro
6N8W A 35 - 189 Show 3D Structure View in InterPro
B 35 - 189 Show 3D Structure View in InterPro
C 35 - 189 Show 3D Structure View in InterPro
D 35 - 189 Show 3D Structure View in InterPro
6N8Y A 35 - 189 Show 3D Structure View in InterPro
HSP90 191 - 217 5UC4 A 191 - 217 Show 3D Structure View in InterPro
B 191 - 217 Show 3D Structure View in InterPro
C 191 - 217 Show 3D Structure View in InterPro
D 191 - 217 Show 3D Structure View in InterPro
5UCH A 191 - 217 Show 3D Structure View in InterPro
B 191 - 217 Show 3D Structure View in InterPro
C 191 - 217 Show 3D Structure View in InterPro
D 191 - 217 Show 3D Structure View in InterPro
5UCI A 191 - 217 Show 3D Structure View in InterPro
B 191 - 217 Show 3D Structure View in InterPro
C 191 - 217 Show 3D Structure View in InterPro
D 191 - 217 Show 3D Structure View in InterPro
5UCJ A 191 - 217 Show 3D Structure View in InterPro
B 191 - 217 Show 3D Structure View in InterPro
C 191 - 217 Show 3D Structure View in InterPro
D 191 - 217 Show 3D Structure View in InterPro
6N8W A 191 - 217 Show 3D Structure View in InterPro
D 191 - 217 Show 3D Structure View in InterPro
191 - 218 6N8W B 191 - 218 Show 3D Structure View in InterPro
191 - 220 6N8Y A 191 - 220 Show 3D Structure View in InterPro
191 - 221 1UYM A 196 - 226 Show 3D Structure View in InterPro
3NMQ A 196 - 226 Show 3D Structure View in InterPro
191 - 222 6N8W C 191 - 222 Show 3D Structure View in InterPro
191 - 690 5FWL A 191 - 690 Show 3D Structure View in InterPro
5FWM A 191 - 690 Show 3D Structure View in InterPro
5FWP A 191 - 690 Show 3D Structure View in InterPro
191 - 691 5FWK A 191 - 691 Show 3D Structure View in InterPro
5FWL B 191 - 691 Show 3D Structure View in InterPro
5FWM B 191 - 691 Show 3D Structure View in InterPro
5FWP B 191 - 691 Show 3D Structure View in InterPro
191 - 692 5FWK B 191 - 692 Show 3D Structure View in InterPro
284 - 543 3PRY A 284 - 543 Show 3D Structure View in InterPro
B 284 - 543 Show 3D Structure View in InterPro
285 - 543 3PRY C 285 - 543 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;