Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SRPRA_HUMAN (P08240)

Summary

This is the summary of UniProt entry SRPRA_HUMAN (P08240).

Description: Signal recognition particle receptor subunit alpha
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 638 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
Pfam SRP-alpha_N 27 303
disorder n/a 131 249
low_complexity n/a 157 177
disorder n/a 254 255
disorder n/a 258 281
disorder n/a 289 315
low_complexity n/a 289 300
Pfam SRP54_N 317 393
disorder n/a 407 408
Pfam SRP54 418 637
disorder n/a 470 478
low_complexity n/a 498 509

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P08240. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MLDFFTIFSK GGLVLWCFQG VSDSCTGPVN ALIRSVLLQE RGGNNSFTHE
50
51
ALTLKYKLDN QFELVFVVGF QKILTLTYVD KLIDDVHRLF RDKYRTEIQQ
100
101
QSALSLLNGT FDFQNDFLRL LREAEESSKI RAPTTMKKFE DSEKAKKPVR
150
151
SMIETRGEKP KEKAKNSKKK GAKKEGSDGP LATSKPVPAE KSGLPVGPEN
200
201
GVELSKEELI RRKREEFIQK HGRGMEKSNK STKSDAPKEK GKKAPRVWEL
250
251
GGCANKEVLD YSTPTTNGTP EAALSEDINL IRGTGSGGQL QDLDCSSSDD
300
301
EGAAQNSTKP SATKGTLGGM FGMLKGLVGS KSLSREDMES VLDKMRDHLI
350
351
AKNVAADIAV QLCESVANKL EGKVMGTFST VTSTVKQALQ ESLVQILQPQ
400
401
RRVDMLRDIM DAQRRQRPYV VTFCGVNGVG KSTNLAKISF WLLENGFSVL
450
451
IAACDTFRAG AVEQLRTHTR RLSALHPPEK HGGRTMVQLF EKGYGKDAAG
500
501
IAMEAIAFAR NQGFDVVLVD TAGRMQDNAP LMTALAKLIT VNTPDLVLFV
550
551
GEALVGNEAV DQLVKFNRAL ADHSMAQTPR LIDGIVLTKF DTIDDKVGAA
600
601
ISMTYITSKP IVFVGTGQTY CDLRSLNAKA VVAALMKA             
638
 

Show the unformatted sequence.

Checksums:
CRC64:967F943CEE3FA79E
MD5:2dbdf99b2dea2585385e999ca470e72e

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
SRP-alpha_N 27 - 129 2FH5 A 27 - 129 Show 3D Structure View in InterPro
27 - 130 2GO5 1 27 - 130 Show 3D Structure View in InterPro
SRP54 418 - 637 5L3Q B 418 - 637 Show 3D Structure View in InterPro
D 418 - 637 Show 3D Structure View in InterPro
6Y32 B 418 - 637 Show 3D Structure View in InterPro
D 418 - 637 Show 3D Structure View in InterPro
F 418 - 637 Show 3D Structure View in InterPro
H 418 - 637 Show 3D Structure View in InterPro
SRP54_N 332 - 393 5L3Q B 332 - 393 Show 3D Structure View in InterPro
D 332 - 393 Show 3D Structure View in InterPro
6Y32 B 332 - 393 Show 3D Structure View in InterPro
D 332 - 393 Show 3D Structure View in InterPro
F 332 - 393 Show 3D Structure View in InterPro
H 332 - 393 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;