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42  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MMP3_HUMAN (P08254)

Summary

This is the summary of UniProt entry MMP3_HUMAN (P08254).

Description: Stromelysin-1 EC=3.4.24.17
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 477 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 17
Pfam PG_binding_1 27 87
Pfam Peptidase_M10 108 264
disorder n/a 193 202
disorder n/a 260 291
low_complexity n/a 269 286
Pfam Hemopexin 296 338
Pfam Hemopexin 340 383
Pfam Hemopexin 388 435
Pfam Hemopexin 437 477
low_complexity n/a 440 449

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P08254. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MKSLPILLLL CVAVCSAYPL DGAARGEDTS MNLVQKYLEN YYDLKKDVKQ
50
51
FVRRKDSGPV VKKIREMQKF LGLEVTGKLD SDTLEVMRKP RCGVPDVGHF
100
101
RTFPGIPKWR KTHLTYRIVN YTPDLPKDAV DSAVEKALKV WEEVTPLTFS
150
151
RLYEGEADIM ISFAVREHGD FYPFDGPGNV LAHAYAPGPG INGDAHFDDD
200
201
EQWTKDTTGT NLFLVAAHEI GHSLGLFHSA NTEALMYPLY HSLTDLTRFR
250
251
LSQDDINGIQ SLYGPPPDSP ETPLVPTEPV PPEPGTPANC DPALSFDAVS
300
301
TLRGEILIFK DRHFWRKSLR KLEPELHLIS SFWPSLPSGV DAAYEVTSKD
350
351
LVFIFKGNQF WAIRGNEVRA GYPRGIHTLG FPPTVRKIDA AISDKEKNKT
400
401
YFFVEDKYWR FDEKRNSMEP GFPKQIAEDF PGIDSKIDAV FEEFGFFYFF
450
451
TGSSQLEFDP NAKKVTHTLK SNSWLNC                         
477
 

Show the unformatted sequence.

Checksums:
CRC64:96194833B907668D
MD5:54d4ff5f55bc2505e1a06f2ed2300520

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Peptidase_M10 108 - 264 1B3D A 91 - 247 Jmol OpenAstexViewer
B 91 - 247 Jmol OpenAstexViewer
1B8Y A 91 - 247 Jmol OpenAstexViewer
1BIW A 91 - 247 Jmol OpenAstexViewer
B 91 - 247 Jmol OpenAstexViewer
1BM6 A 91 - 247 Jmol OpenAstexViewer
1BQO A 91 - 247 Jmol OpenAstexViewer
B 91 - 247 Jmol OpenAstexViewer
1C3I A 91 - 247 Jmol OpenAstexViewer
B 91 - 247 Jmol OpenAstexViewer
1C8T A 91 - 247 Jmol OpenAstexViewer
B 91 - 247 Jmol OpenAstexViewer
1CAQ A 91 - 247 Jmol OpenAstexViewer
1CIZ A 91 - 247 Jmol OpenAstexViewer
1CQR A 91 - 247 Jmol OpenAstexViewer
B 91 - 247 Jmol OpenAstexViewer
1D5J A 91 - 247 Jmol OpenAstexViewer
B 591 - 747 Jmol OpenAstexViewer
1D7X A 91 - 247 Jmol OpenAstexViewer
B 591 - 747 Jmol OpenAstexViewer
1D8F A 91 - 247 Jmol OpenAstexViewer
B 591 - 747 Jmol OpenAstexViewer
1D8M A 91 - 247 Jmol OpenAstexViewer
B 591 - 747 Jmol OpenAstexViewer
1G05 A 91 - 247 Jmol OpenAstexViewer
B 591 - 747 Jmol OpenAstexViewer
1G49 A 91 - 247 Jmol OpenAstexViewer
B 591 - 747 Jmol OpenAstexViewer
1G4K A 91 - 247 Jmol OpenAstexViewer
B 91 - 247 Jmol OpenAstexViewer
C 91 - 247 Jmol OpenAstexViewer
1HFS A 91 - 247 Jmol OpenAstexViewer
1HY7 A 91 - 247 Jmol OpenAstexViewer
B 591 - 747 Jmol OpenAstexViewer
1OO9 A 91 - 247 Jmol OpenAstexViewer
1QIA A 91 - 247 Jmol OpenAstexViewer
B 91 - 247 Jmol OpenAstexViewer
C 91 - 247 Jmol OpenAstexViewer
D 91 - 247 Jmol OpenAstexViewer
1QIC A 91 - 247 Jmol OpenAstexViewer
B 91 - 247 Jmol OpenAstexViewer
C 91 - 247 Jmol OpenAstexViewer
D 91 - 247 Jmol OpenAstexViewer
1SLM A 91 - 247 Jmol OpenAstexViewer
1SLN A 91 - 247 Jmol OpenAstexViewer
1UEA A 91 - 247 Jmol OpenAstexViewer
C 91 - 247 Jmol OpenAstexViewer
1UMS A 91 - 247 Jmol OpenAstexViewer
1UMT A 91 - 247 Jmol OpenAstexViewer
1USN A 91 - 247 Jmol OpenAstexViewer
2D1O A 91 - 247 Jmol OpenAstexViewer
B 91 - 247 Jmol OpenAstexViewer
2JNP A 91 - 247 Jmol OpenAstexViewer
2JT5 A 91 - 247 Jmol OpenAstexViewer
2JT6 A 91 - 247 Jmol OpenAstexViewer
2SRT A 91 - 247 Jmol OpenAstexViewer
2USN A 91 - 247 Jmol OpenAstexViewer
3OHL A 91 - 247 Jmol OpenAstexViewer
3OHO A 91 - 247 Jmol OpenAstexViewer
3USN A 9 - 165 Jmol OpenAstexViewer
4DPE A 91 - 247 Jmol OpenAstexViewer
B 91 - 247 Jmol OpenAstexViewer
4G9L A 91 - 247 Jmol OpenAstexViewer
B 91 - 247 Jmol OpenAstexViewer
4JA1 A 91 - 247 Jmol OpenAstexViewer
B 91 - 247 Jmol OpenAstexViewer
6MAV A 91 - 247 Jmol OpenAstexViewer
6N9D A 91 - 247 Jmol OpenAstexViewer
PG_binding_1 33 - 87 1SLM A 16 - 70 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.