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11  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: INHBA_HUMAN (P08476)

Summary

This is the summary of UniProt entry INHBA_HUMAN (P08476).

Description: Inhibin beta A chain
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 426 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 20
disorder n/a 26 31
disorder n/a 42 43
Pfam TGFb_propeptide 46 295
disorder n/a 111 112
disorder n/a 171 174
disorder n/a 179 194
disorder n/a 197 198
low_complexity n/a 257 285
disorder n/a 258 302
disorder n/a 304 309
Pfam TGF_beta 320 425

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P08476. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPLLWLRGFL LASCWIIVRS SPTPGSEGHS AAPDCPSCAL AALPKDVPNS
50
51
QPEMVEAVKK HILNMLHLKK RPDVTQPVPK AALLNAIRKL HVGKVGENGY
100
101
VEIEDDIGRR AEMNELMEQT SEIITFAESG TARKTLHFEI SKEGSDLSVV
150
151
ERAEVWLFLK VPKANRTRTK VTIRLFQQQK HPQGSLDTGE EAEEVGLKGE
200
201
RSELLLSEKV VDARKSTWHV FPVSSSIQRL LDQGKSSLDV RIACEQCQES
250
251
GASLVLLGKK KKKEEEGEGK KKGGGEGGAG ADEEKEQSHR PFLMLQARQS
300
301
EDHPHRRRRR GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC
350
351
EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS
400
401
MLYYDDGQNI IKKDIQNMIV EECGCS                          
426
 

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Checksums:
CRC64:201CDEDF99CB6919
MD5:b0f0d7c08526ba669da1df28620cfa7c

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
TGF_beta 320 - 425 1NYS B 10 - 115 Jmol OpenAstexViewer
D 10 - 115 Jmol OpenAstexViewer
1NYU B 10 - 115 Jmol OpenAstexViewer
1S4Y B 10 - 115 Jmol OpenAstexViewer
D 10 - 115 Jmol OpenAstexViewer
2ARP A 10 - 115 Jmol OpenAstexViewer
2ARV A 10 - 115 Jmol OpenAstexViewer
B 10 - 115 Jmol OpenAstexViewer
2B0U A 10 - 115 Jmol OpenAstexViewer
B 10 - 115 Jmol OpenAstexViewer
2P6A A 10 - 115 Jmol OpenAstexViewer
B 10 - 115 Jmol OpenAstexViewer
3B4V A 10 - 115 Jmol OpenAstexViewer
B 10 - 115 Jmol OpenAstexViewer
E 10 - 115 Jmol OpenAstexViewer
F 10 - 115 Jmol OpenAstexViewer
5HLY A 320 - 425 Jmol OpenAstexViewer
5HLZ B 320 - 425 Jmol OpenAstexViewer
D 320 - 425 Jmol OpenAstexViewer
F 320 - 425 Jmol OpenAstexViewer
H 320 - 425 Jmol OpenAstexViewer
321 - 425 1NYU D 11 - 115 Jmol OpenAstexViewer
340 - 425 4MID A 33 - 113 Jmol OpenAstexViewer
TGFb_propeptide 51 - 295 5HLY A 51 - 295 Jmol OpenAstexViewer
5HLZ A 51 - 295 Jmol OpenAstexViewer
C 51 - 295 Jmol OpenAstexViewer
E 51 - 295 Jmol OpenAstexViewer
G 51 - 295 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.