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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: STS_HUMAN (P08842)

Summary

This is the summary of UniProt entry STS_HUMAN (P08842).

Description: Steryl-sulfatase EC=3.1.6.2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 583 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 23
Pfam Sulfatase 27 413
transmembrane n/a 186 209
low_complexity n/a 195 208
low_complexity n/a 212 233
transmembrane n/a 216 237
disorder n/a 349 352
Pfam Sulfatase_C 437 572

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P08842. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPLRKMKIPF LLLFFLWEAE SHAASRPNII LVMADDLGIG DPGCYGNKTI
50
51
RTPNIDRLAS GGVKLTQHLA ASPLCTPSRA AFMTGRYPVR SGMASWSRTG
100
101
VFLFTASSGG LPTDEITFAK LLKDQGYSTA LIGKWHLGMS CHSKTDFCHH
150
151
PLHHGFNYFY GISLTNLRDC KPGEGSVFTT GFKRLVFLPL QIVGVTLLTL
200
201
AALNCLGLLH VPLGVFFSLL FLAALILTLF LGFLHYFRPL NCFMMRNYEI
250
251
IQQPMSYDNL TQRLTVEAAQ FIQRNTETPF LLVLSYLHVH TALFSSKDFA
300
301
GKSQHGVYGD AVEEMDWSVG QILNLLDELR LANDTLIYFT SDQGAHVEEV
350
351
SSKGEIHGGS NGIYKGGKAN NWEGGIRVPG ILRWPRVIQA GQKIDEPTSN
400
401
MDIFPTVAKL AGAPLPEDRI IDGRDLMPLL EGKSQRSDHE FLFHYCNAYL
450
451
NAVRWHPQNS TSIWKAFFFT PNFNPVGSNG CFATHVCFCF GSYVTHHDPP
500
501
LLFDISKDPR ERNPLTPASE PRFYEILKVM QEAADRHTQT LPEVPDQFSW
550
551
NNFLWKPWLQ LCCPSTGLSC QCDREKQDKR LSR                  
583
 

Show the unformatted sequence.

Checksums:
CRC64:74746AFA9D21A0A6
MD5:8e23c27e73e151de0f70bbe41d6d9e86

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Sulfatase 27 - 413 1P49 A 27 - 413 Jmol OpenAstexViewer
Sulfatase_C 437 - 572 1P49 A 437 - 572 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.