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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: DOPO_HUMAN (P09172)

Summary

This is the summary of UniProt entry DOPO_HUMAN (P09172).

Description: Dopamine beta-hydroxylase
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 617 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
transmembrane n/a 20 37
low_complexity n/a 24 36
Pfam DOMON 55 172
disorder n/a 208 210
Pfam Cu2_monooxygen 214 341
Pfam Cu2_monoox_C 360 516
disorder n/a 590 614

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P09172. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPALSRWASL PGPSMREAAF MYSTAVAIFL VILVAALQGS APRESPLPYH
50
51
IPLDPEGSLE LSWNVSYTQE AIHFQLLVRR LKAGVLFGMS DRGELENADL
100
101
VVLWTDGDTA YFADAWSDQK GQIHLDPQQD YQLLQVQRTP EGLTLLFKRP
150
151
FGTCDPKDYL IEDGTVHLVY GILEEPFRSL EAINGSGLQM GLQRVQLLKP
200
201
NIPEPELPSD ACTMEVQAPN IQIPSQETTY WCYIKELPKG FSRHHIIKYE
250
251
PIVTKGNEAL VHHMEVFQCA PEMDSVPHFS GPCDSKMKPD RLNYCRHVLA
300
301
AWALGAKAFY YPEEAGLAFG GPGSSRYLRL EVHYHNPLVI EGRNDSSGIR
350
351
LYYTAKLRRF NAGIMELGLV YTPVMAIPPR ETAFILTGYC TDKCTQLALP
400
401
PSGIHIFASQ LHTHLTGRKV VTVLVRDGRE WEIVNQDNHY SPHFQEIRML
450
451
KKVVSVHPGD VLITSCTYNT EDRELATVGG FGILEEMCVN YVHYYPQTQL
500
501
ELCKSAVDAG FLQKYFHLIN RFNNEDVCTC PQASVSQQFT SVPWNSFNRD
550
551
VLKALYSFAP ISMHCNKSSA VRFQGEWNLQ PLPKVISTLE EPTPQCPTSQ
600
601
GRSPAGPTVV SIGGGKG                                    
617
 

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Checksums:
CRC64:4D5586F0E358885D
MD5:38927ee2935860a9742a6d5ccb6d1ece

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Cu2_monoox_C 360 - 516 4ZEL A 360 - 516 Jmol OpenAstexViewer
B 360 - 516 Jmol OpenAstexViewer
Cu2_monooxygen 214 - 341 4ZEL A 214 - 341 Jmol OpenAstexViewer
B 214 - 341 Jmol OpenAstexViewer
DOMON 55 - 172 4ZEL A 55 - 172 Jmol OpenAstexViewer
B 55 - 172 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.