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11  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MMP7_HUMAN (P09237)

Summary

This is the summary of UniProt entry MMP7_HUMAN (P09237).

Description: Matrilysin EC=3.4.24.23
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 267 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 17
Pfam PG_binding_1 28 82
coiled_coil n/a 45 65
Pfam Peptidase_M10 103 259
disorder n/a 191 192
disorder n/a 230 234
disorder n/a 237 238
disorder n/a 244 245
disorder n/a 255 259
disorder n/a 262 267

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P09237. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MRLTVLCAVC LLPGSLALPL PQEAGGMSEL QWEQAQDYLK RFYLYDSETK
50
51
NANSLEAKLK EMQKFFGLPI TGMLNSRVIE IMQKPRCGVP DVAEYSLFPN
100
101
SPKWTSKVVT YRIVSYTRDL PHITVDRLVS KALNMWGKEI PLHFRKVVWG
150
151
TADIMIGFAR GAHGDSYPFD GPGNTLAHAF APGTGLGGDA HFDEDERWTD
200
201
GSSLGINFLY AATHELGHSL GMGHSSDPNA VMYPTYGNGD PQNFKLSQDD
250
251
IKGIQKLYGK RSNSRKK                                    
267
 

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Checksums:
CRC64:F6BD1FC0ADA23603
MD5:94bc4adef58a1fd2edf329315db6b81b

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Peptidase_M10 103 - 258 2Y6C A 108 - 263 Jmol OpenAstexViewer
103 - 259 1MMP A 108 - 263 Jmol OpenAstexViewer
B 108 - 263 Jmol OpenAstexViewer
1MMQ A 108 - 263 Jmol OpenAstexViewer
1MMR A 108 - 263 Jmol OpenAstexViewer
2DDY A 9 - 165 Jmol OpenAstexViewer
2MZE A 83 - 239 Jmol OpenAstexViewer
2MZH A 83 - 239 Jmol OpenAstexViewer
2MZI A 83 - 239 Jmol OpenAstexViewer
2Y6D A 108 - 264 Jmol OpenAstexViewer
5UE2 A 83 - 239 Jmol OpenAstexViewer
5UE5 A 83 - 239 Jmol OpenAstexViewer
PG_binding_1 28 - 82 2MZE A 8 - 62 Jmol OpenAstexViewer
2MZH A 8 - 62 Jmol OpenAstexViewer
2MZI A 8 - 62 Jmol OpenAstexViewer
5UE2 A 8 - 62 Jmol OpenAstexViewer
5UE5 A 8 - 62 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.