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19  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ROA1_HUMAN (P09651)

Summary

This is the summary of UniProt entry ROA1_HUMAN (P09651).

Description: Heterogeneous nuclear ribonucleoprotein A1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 372 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 11
Pfam RRM_1 16 85
disorder n/a 74 96
Pfam RRM_1 107 176
disorder n/a 178 210
low_complexity n/a 189 319
disorder n/a 213 216
disorder n/a 221 225
disorder n/a 227 235
disorder n/a 239 241
disorder n/a 247 248
disorder n/a 254 286
disorder n/a 292 294
disorder n/a 298 303
Pfam HnRNPA1 307 344
disorder n/a 310 313
disorder n/a 317 321
disorder n/a 323 337
low_complexity n/a 329 344
disorder n/a 339 372
low_complexity n/a 354 368

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P09651. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSKSESPKEP EQLRKLFIGG LSFETTDESL RSHFEQWGTL TDCVVMRDPN
50
51
TKRSRGFGFV TYATVEEVDA AMNARPHKVD GRVVEPKRAV SREDSQRPGA
100
101
HLTVKKIFVG GIKEDTEEHH LRDYFEQYGK IEVIEIMTDR GSGKKRGFAF
150
151
VTFDDHDSVD KIVIQKYHTV NGHNCEVRKA LSKQEMASAS SSQRGRSGSG
200
201
NFGGGRGGGF GGNDNFGRGG NFSGRGGFGG SRGGGGYGGS GDGYNGFGND
250
251
GGYGGGGPGY SGGSRGYGSG GQGYGNQGSG YGGSGSYDSY NNGGGGGFGG
300
301
GSGSNFGGGG SYNDFGNYNN QSSNFGPMKG GNFGGRSSGP YGGGGQYFAK
350
351
PRNQGGYGGS SSSSSYGSGR RF                              
372
 

Show the unformatted sequence.

Checksums:
CRC64:A06683571C6C109F
MD5:635b53c9fc307302b28ffb8f156a36b4

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
HnRNPA1 315 - 341 2H4M D 263 - 289 Jmol OpenAstexViewer
319 - 341 2H4M C 267 - 289 Jmol OpenAstexViewer
RRM_1 107 - 176 1HA1 A 106 - 175 Jmol OpenAstexViewer
1L3K A 107 - 176 Jmol OpenAstexViewer
1PGZ A 107 - 176 Jmol OpenAstexViewer
1PO6 A 107 - 176 Jmol OpenAstexViewer
1U1K A 107 - 176 Jmol OpenAstexViewer
1U1L A 107 - 176 Jmol OpenAstexViewer
1U1M A 107 - 176 Jmol OpenAstexViewer
1U1N A 107 - 176 Jmol OpenAstexViewer
1U1O A 107 - 176 Jmol OpenAstexViewer
1U1P A 107 - 176 Jmol OpenAstexViewer
1U1Q A 107 - 176 Jmol OpenAstexViewer
1U1R A 107 - 176 Jmol OpenAstexViewer
1UP1 A 107 - 176 Jmol OpenAstexViewer
2LYV A 107 - 176 Jmol OpenAstexViewer
2UP1 A 107 - 176 Jmol OpenAstexViewer
4YOE A 107 - 176 Jmol OpenAstexViewer
5MPL A 107 - 176 Jmol OpenAstexViewer
16 - 85 1HA1 A 15 - 84 Jmol OpenAstexViewer
1L3K A 16 - 85 Jmol OpenAstexViewer
1PGZ A 16 - 85 Jmol OpenAstexViewer
1PO6 A 16 - 85 Jmol OpenAstexViewer
1U1K A 16 - 85 Jmol OpenAstexViewer
1U1L A 16 - 85 Jmol OpenAstexViewer
1U1M A 16 - 85 Jmol OpenAstexViewer
1U1N A 16 - 85 Jmol OpenAstexViewer
1U1O A 16 - 85 Jmol OpenAstexViewer
1U1P A 16 - 85 Jmol OpenAstexViewer
1U1Q A 16 - 85 Jmol OpenAstexViewer
1U1R A 16 - 85 Jmol OpenAstexViewer
1UP1 A 16 - 85 Jmol OpenAstexViewer
2LYV A 16 - 85 Jmol OpenAstexViewer
2UP1 A 16 - 85 Jmol OpenAstexViewer
4YOE A 16 - 85 Jmol OpenAstexViewer
5MPG A 16 - 85 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.