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56  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PARP1_HUMAN (P09874)

Summary

This is the summary of UniProt entry PARP1_HUMAN (P09874).

Description: Poly [ADP-ribose] polymerase 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 1014 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
Pfam zf-PARP 12 89
disorder n/a 85 101
Pfam zf-PARP 116 199
disorder n/a 138 145
disorder n/a 197 222
low_complexity n/a 219 238
disorder n/a 224 227
disorder n/a 230 233
Pfam PADR1 280 331
low_complexity n/a 357 385
disorder n/a 359 383
Pfam BRCT 385 462
disorder n/a 412 414
coiled_coil n/a 429 456
disorder n/a 430 431
low_complexity n/a 432 447
disorder n/a 433 434
disorder n/a 439 446
low_complexity n/a 482 494
low_complexity n/a 496 508
disorder n/a 498 499
disorder n/a 503 515
disorder n/a 538 540
Pfam WGR 553 633
disorder n/a 656 660
Pfam PARP_reg 663 794
Pfam PARP 808 1007
disorder n/a 947 950
low_complexity n/a 997 1009

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P09874. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAESSDKLYR VEYAKSGRAS CKKCSESIPK DSLRMAIMVQ SPMFDGKVPH
50
51
WYHFSCFWKV GHSIRHPDVE VDGFSELRWD DQQKVKKTAE AGGVTGKGQD
100
101
GIGSKAEKTL GDFAAEYAKS NRSTCKGCME KIEKGQVRLS KKMVDPEKPQ
150
151
LGMIDRWYHP GCFVKNREEL GFRPEYSASQ LKGFSLLATE DKEALKKQLP
200
201
GVKSEGKRKG DEVDGVDEVA KKKSKKEKDK DSKLEKALKA QNDLIWNIKD
250
251
ELKKVCSTND LKELLIFNKQ QVPSGESAIL DRVADGMVFG ALLPCEECSG
300
301
QLVFKSDAYY CTGDVTAWTK CMVKTQTPNR KEWVTPKEFR EISYLKKLKV
350
351
KKQDRIFPPE TSASVAATPP PSTASAPAAV NSSASADKPL SNMKILTLGK
400
401
LSRNKDEVKA MIEKLGGKLT GTANKASLCI STKKEVEKMN KKMEEVKEAN
450
451
IRVVSEDFLQ DVSASTKSLQ ELFLAHILSP WGAEVKAEPV EVVAPRGKSG
500
501
AALSKKSKGQ VKEEGINKSE KRMKLTLKGG AAVDPDSGLE HSAHVLEKGG
550
551
KVFSATLGLV DIVKGTNSYY KLQLLEDDKE NRYWIFRSWG RVGTVIGSNK
600
601
LEQMPSKEDA IEHFMKLYEE KTGNAWHSKN FTKYPKKFYP LEIDYGQDEE
650
651
AVKKLTVNPG TKSKLPKPVQ DLIKMIFDVE SMKKAMVEYE IDLQKMPLGK
700
701
LSKRQIQAAY SILSEVQQAV SQGSSDSQIL DLSNRFYTLI PHDFGMKKPP
750
751
LLNNADSVQA KVEMLDNLLD IEVAYSLLRG GSDDSSKDPI DVNYEKLKTD
800
801
IKVVDRDSEE AEIIRKYVKN THATTHNAYD LEVIDIFKIE REGECQRYKP
850
851
FKQLHNRRLL WHGSRTTNFA GILSQGLRIA PPEAPVTGYM FGKGIYFADM
900
901
VSKSANYCHT SQGDPIGLIL LGEVALGNMY ELKHASHISK LPKGKHSVKG
950
951
LGKTTPDPSA NISLDGVDVP LGTGISSGVN DTSLLYNEYI VYDIAQVNLK
1000
1001
YLLKLKFNFK TSLW                                       
1014
 

Show the unformatted sequence.

Checksums:
CRC64:6A5FC01EB91C046B
MD5:eb3e1a3d88e5ed82c3e0e8049af7a563

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
BRCT 387 - 462 2COK A 8 - 83 Jmol OpenAstexViewer
PADR1 280 - 331 2JVN A 280 - 331 Jmol OpenAstexViewer
2RIQ A 280 - 331 Jmol OpenAstexViewer
4DQY B 280 - 331 Jmol OpenAstexViewer
E 280 - 331 Jmol OpenAstexViewer
4OPX A 280 - 331 Jmol OpenAstexViewer
D 280 - 331 Jmol OpenAstexViewer
4OQA A 280 - 331 Jmol OpenAstexViewer
D 280 - 331 Jmol OpenAstexViewer
4OQB A 280 - 331 Jmol OpenAstexViewer
D 280 - 331 Jmol OpenAstexViewer
PARP 808 - 1004 4HHY D 147 - 343 Jmol OpenAstexViewer
808 - 1007 1UK0 A 147 - 346 Jmol OpenAstexViewer
B 147 - 346 Jmol OpenAstexViewer
1UK1 A 808 - 1007 Jmol OpenAstexViewer
B 808 - 1007 Jmol OpenAstexViewer
1WOK A 808 - 1007 Jmol OpenAstexViewer
B 808 - 1007 Jmol OpenAstexViewer
C 808 - 1007 Jmol OpenAstexViewer
D 808 - 1007 Jmol OpenAstexViewer
2RCW A 147 - 346 Jmol OpenAstexViewer
2RD6 A 147 - 346 Jmol OpenAstexViewer
3GJW A 147 - 346 Jmol OpenAstexViewer
3GN7 A 147 - 346 Jmol OpenAstexViewer
3L3L A 147 - 346 Jmol OpenAstexViewer
3L3M A 147 - 346 Jmol OpenAstexViewer
4DQY C 808 - 1007 Jmol OpenAstexViewer
F 808 - 1007 Jmol OpenAstexViewer
4GV7 A 808 - 1007 Jmol OpenAstexViewer
B 808 - 1007 Jmol OpenAstexViewer
C 808 - 1007 Jmol OpenAstexViewer
D 808 - 1007 Jmol OpenAstexViewer
4HHY A 147 - 346 Jmol OpenAstexViewer
B 147 - 346 Jmol OpenAstexViewer
C 147 - 346 Jmol OpenAstexViewer
4HHZ A 147 - 346 Jmol OpenAstexViewer
B 147 - 346 Jmol OpenAstexViewer
C 147 - 346 Jmol OpenAstexViewer
D 147 - 346 Jmol OpenAstexViewer
4L6S A 808 - 1007 Jmol OpenAstexViewer
B 808 - 1007 Jmol OpenAstexViewer
4OPX C 808 - 1007 Jmol OpenAstexViewer
F 808 - 1007 Jmol OpenAstexViewer
4OQA C 808 - 1007 Jmol OpenAstexViewer
F 808 - 1007 Jmol OpenAstexViewer
4OQB C 808 - 1007 Jmol OpenAstexViewer
F 808 - 1007 Jmol OpenAstexViewer
4PJT A 808 - 1007 Jmol OpenAstexViewer
B 808 - 1007 Jmol OpenAstexViewer
C 808 - 1007 Jmol OpenAstexViewer
D 808 - 1007 Jmol OpenAstexViewer
4R5W A 808 - 1007 Jmol OpenAstexViewer
B 808 - 1007 Jmol OpenAstexViewer
4R6E A 808 - 1007 Jmol OpenAstexViewer
B 808 - 1007 Jmol OpenAstexViewer
C 808 - 1007 Jmol OpenAstexViewer
D 808 - 1007 Jmol OpenAstexViewer
4RV6 A 808 - 1007 Jmol OpenAstexViewer
B 808 - 1007 Jmol OpenAstexViewer
C 808 - 1007 Jmol OpenAstexViewer
D 808 - 1007 Jmol OpenAstexViewer
4UND A 808 - 1007 Jmol OpenAstexViewer
B 808 - 1007 Jmol OpenAstexViewer
4UXB A 808 - 1007 Jmol OpenAstexViewer
B 808 - 1007 Jmol OpenAstexViewer
4XHU A 808 - 1007 Jmol OpenAstexViewer
C 808 - 1007 Jmol OpenAstexViewer
4ZZZ A 808 - 1007 Jmol OpenAstexViewer
B 808 - 1007 Jmol OpenAstexViewer
5A00 A 808 - 1007 Jmol OpenAstexViewer
5DS3 A 808 - 1007 Jmol OpenAstexViewer
5HA9 A 147 - 346 Jmol OpenAstexViewer
B 147 - 346 Jmol OpenAstexViewer
5KPN A 808 - 1007 Jmol OpenAstexViewer
B 808 - 1007 Jmol OpenAstexViewer
5KPO A 808 - 1007 Jmol OpenAstexViewer
B 808 - 1007 Jmol OpenAstexViewer
5KPP A 808 - 1007 Jmol OpenAstexViewer
B 808 - 1007 Jmol OpenAstexViewer
5KPQ A 808 - 1007 Jmol OpenAstexViewer
B 808 - 1007 Jmol OpenAstexViewer
5WRQ A 808 - 1007 Jmol OpenAstexViewer
B 808 - 1007 Jmol OpenAstexViewer
5WRY A 808 - 1007 Jmol OpenAstexViewer
B 808 - 1007 Jmol OpenAstexViewer
5WRZ A 808 - 1007 Jmol OpenAstexViewer
B 808 - 1007 Jmol OpenAstexViewer
5WS0 A 808 - 1007 Jmol OpenAstexViewer
B 808 - 1007 Jmol OpenAstexViewer
5WS1 A 808 - 1007 Jmol OpenAstexViewer
B 808 - 1007 Jmol OpenAstexViewer
5WTC A 808 - 1007 Jmol OpenAstexViewer
B 808 - 1007 Jmol OpenAstexViewer
5XSR A 147 - 346 Jmol OpenAstexViewer
5XST A 147 - 346 Jmol OpenAstexViewer
5XSU A 147 - 346 Jmol OpenAstexViewer
B 147 - 346 Jmol OpenAstexViewer
C 147 - 346 Jmol OpenAstexViewer
D 147 - 346 Jmol OpenAstexViewer
6BHV A 808 - 1007 Jmol OpenAstexViewer
B 808 - 1007 Jmol OpenAstexViewer
C 808 - 1007 Jmol OpenAstexViewer
D 808 - 1007 Jmol OpenAstexViewer
PARP_reg 663 - 794 1UK0 A 2 - 133 Jmol OpenAstexViewer
B 2 - 133 Jmol OpenAstexViewer
1UK1 A 663 - 794 Jmol OpenAstexViewer
B 663 - 794 Jmol OpenAstexViewer
1WOK A 663 - 794 Jmol OpenAstexViewer
B 663 - 794 Jmol OpenAstexViewer
C 663 - 794 Jmol OpenAstexViewer
D 663 - 794 Jmol OpenAstexViewer
2RCW A 2 - 133 Jmol OpenAstexViewer
2RD6 A 2 - 133 Jmol OpenAstexViewer
3GJW A 2 - 133 Jmol OpenAstexViewer
3GN7 A 2 - 133 Jmol OpenAstexViewer
3L3L A 2 - 133 Jmol OpenAstexViewer
3L3M A 2 - 133 Jmol OpenAstexViewer
4DQY C 663 - 794 Jmol OpenAstexViewer
F 663 - 794 Jmol OpenAstexViewer
4GV7 A 663 - 794 Jmol OpenAstexViewer
B 663 - 794 Jmol OpenAstexViewer
C 663 - 794 Jmol OpenAstexViewer
D 663 - 794 Jmol OpenAstexViewer
4HHY A 2 - 133 Jmol OpenAstexViewer
B 2 - 133 Jmol OpenAstexViewer
C 2 - 133 Jmol OpenAstexViewer
4HHZ A 2 - 133 Jmol OpenAstexViewer
B 2 - 133 Jmol OpenAstexViewer
C 2 - 133 Jmol OpenAstexViewer
D 2 - 133 Jmol OpenAstexViewer
4L6S A 663 - 794 Jmol OpenAstexViewer
B 663 - 794 Jmol OpenAstexViewer
4OPX C 663 - 794 Jmol OpenAstexViewer
F 663 - 794 Jmol OpenAstexViewer
4OQA C 663 - 794 Jmol OpenAstexViewer
F 663 - 794 Jmol OpenAstexViewer
4OQB C 663 - 794 Jmol OpenAstexViewer
F 663 - 794 Jmol OpenAstexViewer
4PJT A 663 - 794 Jmol OpenAstexViewer
B 663 - 794 Jmol OpenAstexViewer
C 663 - 794 Jmol OpenAstexViewer
D 663 - 794 Jmol OpenAstexViewer
4R5W A 663 - 794 Jmol OpenAstexViewer
B 663 - 794 Jmol OpenAstexViewer
4R6E A 663 - 794 Jmol OpenAstexViewer
B 663 - 794 Jmol OpenAstexViewer
C 663 - 794 Jmol OpenAstexViewer
D 663 - 794 Jmol OpenAstexViewer
4RV6 A 663 - 794 Jmol OpenAstexViewer
B 663 - 794 Jmol OpenAstexViewer
C 663 - 794 Jmol OpenAstexViewer
D 663 - 794 Jmol OpenAstexViewer
4UND A 663 - 794 Jmol OpenAstexViewer
B 663 - 794 Jmol OpenAstexViewer
4UXB A 663 - 794 Jmol OpenAstexViewer
B 663 - 794 Jmol OpenAstexViewer
4XHU A 663 - 794 Jmol OpenAstexViewer
4ZZZ A 663 - 794 Jmol OpenAstexViewer
5A00 A 663 - 794 Jmol OpenAstexViewer
5HA9 A 2 - 133 Jmol OpenAstexViewer
B 2 - 133 Jmol OpenAstexViewer
5KPN A 663 - 794 Jmol OpenAstexViewer
B 663 - 794 Jmol OpenAstexViewer
5KPO A 663 - 794 Jmol OpenAstexViewer
B 663 - 794 Jmol OpenAstexViewer
5KPP A 663 - 794 Jmol OpenAstexViewer
B 663 - 794 Jmol OpenAstexViewer
5KPQ A 663 - 794 Jmol OpenAstexViewer
B 663 - 794 Jmol OpenAstexViewer
5WRQ A 663 - 794 Jmol OpenAstexViewer
B 663 - 794 Jmol OpenAstexViewer
5WRY A 663 - 794 Jmol OpenAstexViewer
B 663 - 794 Jmol OpenAstexViewer
5WRZ A 663 - 794 Jmol OpenAstexViewer
B 663 - 794 Jmol OpenAstexViewer
5WS0 A 663 - 794 Jmol OpenAstexViewer
B 663 - 794 Jmol OpenAstexViewer
5WS1 A 663 - 794 Jmol OpenAstexViewer
B 663 - 794 Jmol OpenAstexViewer
5WTC A 663 - 794 Jmol OpenAstexViewer
B 663 - 794 Jmol OpenAstexViewer
5XSR A 2 - 133 Jmol OpenAstexViewer
5XST A 2 - 133 Jmol OpenAstexViewer
5XSU A 2 - 133 Jmol OpenAstexViewer
B 2 - 133 Jmol OpenAstexViewer
C 2 - 133 Jmol OpenAstexViewer
664 - 794 4ZZZ B 664 - 794 Jmol OpenAstexViewer
665 - 794 4HHY D 4 - 133 Jmol OpenAstexViewer
4XHU C 665 - 794 Jmol OpenAstexViewer
5XSU D 4 - 133 Jmol OpenAstexViewer
788 - 794 5DS3 A 788 - 794 Jmol OpenAstexViewer
789 - 794 6BHV A 789 - 794 Jmol OpenAstexViewer
B 789 - 794 Jmol OpenAstexViewer
C 789 - 794 Jmol OpenAstexViewer
D 789 - 794 Jmol OpenAstexViewer
WGR 553 - 633 2CR9 A 43 - 123 Jmol OpenAstexViewer
4DQY C 553 - 633 Jmol OpenAstexViewer
F 553 - 633 Jmol OpenAstexViewer
4OPX C 553 - 633 Jmol OpenAstexViewer
F 553 - 633 Jmol OpenAstexViewer
4OQA C 553 - 633 Jmol OpenAstexViewer
F 553 - 633 Jmol OpenAstexViewer
4OQB C 553 - 633 Jmol OpenAstexViewer
F 553 - 633 Jmol OpenAstexViewer
zf-PARP 116 - 199 2CS2 A 21 - 104 Jmol OpenAstexViewer
2L31 A 116 - 199 Jmol OpenAstexViewer
2N8A A 116 - 199 Jmol OpenAstexViewer
3ODC A 116 - 199 Jmol OpenAstexViewer
B 116 - 199 Jmol OpenAstexViewer
3ODE A 116 - 199 Jmol OpenAstexViewer
B 116 - 199 Jmol OpenAstexViewer
4AV1 B 116 - 199 Jmol OpenAstexViewer
D 116 - 199 Jmol OpenAstexViewer
12 - 89 2DMJ A 19 - 96 Jmol OpenAstexViewer
2L30 A 12 - 89 Jmol OpenAstexViewer
2N8A A 12 - 89 Jmol OpenAstexViewer
3OD8 A 12 - 89 Jmol OpenAstexViewer
B 12 - 89 Jmol OpenAstexViewer
C 12 - 89 Jmol OpenAstexViewer
D 12 - 89 Jmol OpenAstexViewer
E 12 - 89 Jmol OpenAstexViewer
F 12 - 89 Jmol OpenAstexViewer
G 12 - 89 Jmol OpenAstexViewer
H 12 - 89 Jmol OpenAstexViewer
3ODA A 12 - 89 Jmol OpenAstexViewer
B 12 - 89 Jmol OpenAstexViewer
C 12 - 89 Jmol OpenAstexViewer
D 12 - 89 Jmol OpenAstexViewer
E 12 - 89 Jmol OpenAstexViewer
F 12 - 89 Jmol OpenAstexViewer
G 12 - 89 Jmol OpenAstexViewer
H 12 - 89 Jmol OpenAstexViewer
4AV1 A 12 - 89 Jmol OpenAstexViewer
C 12 - 89 Jmol OpenAstexViewer
4DQY A 12 - 89 Jmol OpenAstexViewer
D 12 - 89 Jmol OpenAstexViewer
4OPX A 12 - 89 Jmol OpenAstexViewer
D 12 - 89 Jmol OpenAstexViewer
4OQA A 12 - 89 Jmol OpenAstexViewer
D 12 - 89 Jmol OpenAstexViewer
4OQB A 12 - 89 Jmol OpenAstexViewer
D 12 - 89 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.