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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: ACRA_ECOLI (P0AE06)

Summary

This is the summary of UniProt entry ACRA_ECOLI (P0AE06).

Description: Multidrug efflux pump subunit AcrA
Source organism: Escherichia coli (strain K12) (NCBI taxonomy ID 83333)
View Pfam proteome data.
Length: 397 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 21
disorder n/a 27 28
disorder n/a 36 38
Pfam HlyD 37 361
Pfam HlyD_D23 49 293
low_complexity n/a 107 118
low_complexity n/a 112 121
low_complexity n/a 140 166
disorder n/a 291 293
disorder n/a 306 313
disorder n/a 318 320
disorder n/a 322 326
disorder n/a 372 397

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P0AE06. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MNKNRGFTPL AVVLMLSGSL ALTGCDDKQA QQGGQQMPAV GVVTVKTEPL
50
51
QITTELPGRT SAYRIAEVRP QVSGIILKRN FKEGSDIEAG VSLYQIDPAT
100
101
YQATYDSAKG DLAKAQAAAN IAQLTVNRYQ KLLGTQYISK QEYDQALADA
150
151
QQANAAVTAA KAAVETARIN LAYTKVTSPI SGRIGKSNVT EGALVQNGQA
200
201
TALATVQQLD PIYVDVTQSS NDFLRLKQEL ANGTLKQENG KAKVSLITSD
250
251
GIKFPQDGTL EFSDVTVDQT TGSITLRAIF PNPDHTLLPG MFVRARLEEG
300
301
LNPNAILVPQ QGVTRTPRGD ATVLVVGADD KVETRPIVAS QAIGDKWLVT
350
351
EGLKAGDRVV ISGLQKVRPG VQVKAQEVTA DNNQQAASGA QPEQSKS   
397
 

Show the unformatted sequence.

Checksums:
CRC64:5B81DD5BC2B0A077
MD5:52762d32c4bba225824c9d1a93b2d1b3

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
HlyD 53 - 297 2F1M B 53 - 297 Jmol OpenAstexViewer
53 - 298 2F1M A 53 - 298 Jmol OpenAstexViewer
53 - 299 2F1M C 53 - 299 Jmol OpenAstexViewer
54 - 297 2F1M D 54 - 297 Jmol OpenAstexViewer
HlyD_D23 53 - 293 2F1M A 53 - 293 Jmol OpenAstexViewer
B 53 - 293 Jmol OpenAstexViewer
C 53 - 293 Jmol OpenAstexViewer
54 - 293 2F1M D 54 - 293 Jmol OpenAstexViewer