Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: H2A1_HUMAN (P0C0S8)

Summary

This is the summary of UniProt entry H2A1_HUMAN (P0C0S8).

Description: Histone H2A type 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 130 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 1 19
low_complexity n/a 1 22
Pfam Histone 2 91
disorder n/a 81 82
Pfam Histone_H2A_C 92 126
disorder n/a 119 121
disorder n/a 123 130

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P0C0S8. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSGRGKQGGK ARAKAKTRSS RAGLQFPVGR VHRLLRKGNY AERVGAGAPV
50
51
YLAAVLEYLT AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGK
100
101
VTIAQGGVLP NIQAVLLPKK TESHHKAKGK                      
130
 

Show the unformatted sequence.

Checksums:
CRC64:48DD539793FE8256
MD5:cafc078a197b33a059663a9c7d1ac119

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Histone 10 - 91 5KGF C 9 - 90 Jmol OpenAstexViewer
G 9 - 90 Jmol OpenAstexViewer
2 - 11 4QYL E 1 - 10 Jmol OpenAstexViewer
F 1 - 10 Jmol OpenAstexViewer
G 1 - 10 Jmol OpenAstexViewer
H 1 - 10 Jmol OpenAstexViewer
Histone_H2A_C 92 - 122 5KGF C 91 - 121 Jmol OpenAstexViewer
G 91 - 121 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.